Non-Small Cell Lung Carcinoma Advanced Locally unresectable TNM clinical staging | Pleural effusion | Non-small cell lung cancer metastatic unresectable TNM clinical staging
Item
histologically or cytologically confirmed, unresectable locally advanced (stage iiib with pleural effusion) and/or metastatic (stage iv) nsclc
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C1519810 (UMLS CUI [1,4])
C3258246 (UMLS CUI [1,5])
C0032227 (UMLS CUI [2])
C0278987 (UMLS CUI [3,1])
C1519810 (UMLS CUI [3,2])
C3258246 (UMLS CUI [3,3])
Disease Progression | First line treatment Non-Small Cell Lung Carcinoma Advanced | First line treatment Non-small cell lung cancer metastatic
Item
progression to first-line therapy for advanced/metastatic nsclc
boolean
C0242656 (UMLS CUI [1])
C1708063 (UMLS CUI [2,1])
C0007131 (UMLS CUI [2,2])
C0205179 (UMLS CUI [2,3])
C1708063 (UMLS CUI [3,1])
C0278987 (UMLS CUI [3,2])
Measurable Disease 2-Dimensional outside Radiation Field
Item
bi-dimensionally measurable disease (not included in radiation field)
boolean
C1513041 (UMLS CUI [1,1])
C1705052 (UMLS CUI [1,2])
C0205101 (UMLS CUI [1,3])
C1882536 (UMLS CUI [1,4])
ECOG performance status
Item
ecog performance status of 0-2
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy of more than 6 months
boolean
C0023671 (UMLS CUI [1])
Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Secondary malignant neoplasm of liver Absent | Secondary malignant neoplasm of liver Present | Renal function | Creatinine measurement, serum | Bone Marrow function | Neutrophil count | Platelet Count measurement
Item
adequate liver (serum bilirubin <1.5 times the upper normal limit, ast and alt <2.5 times the upper normal limit in the absence of demonstrable liver metastases, or <5 times the upper normal limit in the presence of liver metastases,adequate renal function (serum creatinine <1.5 times the upper normal limit),and bone marrow (neutrophils ≥ 1.5x 109 /l, and platelets ≥ 100x 109 /l) function
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C0494165 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0494165 (UMLS CUI [6,1])
C0150312 (UMLS CUI [6,2])
C0232804 (UMLS CUI [7])
C0201976 (UMLS CUI [8])
C0005953 (UMLS CUI [9,1])
C0031843 (UMLS CUI [9,2])
C0200633 (UMLS CUI [10])
C0032181 (UMLS CUI [11])
Informed Consent
Item
signed informed consent
boolean
C0021430 (UMLS CUI [1])
Central Nervous System Involvement | Exception Therapeutic radiology procedure | Exception Patient Stable status
Item
central nervous system involvement (unless if the patient has being previously irradiated and is clinically stable)
boolean
C4050309 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1522449 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0030705 (UMLS CUI [3,2])
C0205360 (UMLS CUI [3,3])
Mass Location Central | Tumor Mass Relation Large vessels | Mass Cavitation
Item
presence of a centrally located mass or a tumor mass in close relation to large vessels or a mass with cavitation.
boolean
C0577559 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C0205099 (UMLS CUI [1,3])
C3273930 (UMLS CUI [2,1])
C0439849 (UMLS CUI [2,2])
C0225990 (UMLS CUI [2,3])
C0577559 (UMLS CUI [3,1])
C1510420 (UMLS CUI [3,2])
Operative Surgical Procedures | Therapeutic radiology procedure
Item
surgery or radiation therapy within the last 14 days from study entry
boolean
C0543467 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
Communicable Disease
Item
active infection
boolean
C0009450 (UMLS CUI [1])
Hemoptysis Life Threatening | Hematemesis | Thrombosis | Anticoagulation Therapy
Item
history of life-threatening hemoptysis / hematemesis, history of thrombosis or use of anti-coagulation therapy
boolean
C0019079 (UMLS CUI [1,1])
C2826244 (UMLS CUI [1,2])
C0018926 (UMLS CUI [2])
C0040053 (UMLS CUI [3])
C0003281 (UMLS CUI [4])
Heart Disease | Angina, Unstable | Congestive heart failure | Myocardial Infarction | Ventricular arrhythmia | Cerebrovascular accident | Uncontrolled hypertension
Item
history of significant cardiac disease (unstable angina, congestive heart failure, myocardial infarction, ventricular arrhythmias) or stroke within the previous 6 months or uncontrolled hypertension
boolean
C0018799 (UMLS CUI [1])
C0002965 (UMLS CUI [2])
C0018802 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
C0085612 (UMLS CUI [5])
C0038454 (UMLS CUI [6])
C1868885 (UMLS CUI [7])
Study Subject Participation Status | Treatment Protocols Investigational
Item
patients on other experimental treatment protocols
boolean
C2348568 (UMLS CUI [1])
C0040808 (UMLS CUI [2,1])
C1517586 (UMLS CUI [2,2])
Primary tumor second | Exception Basal cell carcinoma | Exception Carcinoma in situ of uterine cervix
Item
history of a second primary malignancy (other than basal-cell skin carcinoma or in situ carcinoma of the cervix)
boolean
C0677930 (UMLS CUI [1,1])
C0205436 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
Mental disorders Protocol Compliance Excluded | Social situation Protocol Compliance Excluded
Item
psychiatric illness or social situation that would preclude study compliance
boolean
C0004936 (UMLS CUI [1,1])
C0525058 (UMLS CUI [1,2])
C0332196 (UMLS CUI [1,3])
C0748872 (UMLS CUI [2,1])
C0525058 (UMLS CUI [2,2])
C0332196 (UMLS CUI [2,3])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])