Non-small cell carcinoma | Squamous cell carcinoma | Adenocarcinoma | Bronchioalveolar carcinoma Feature | Bronchioalveolar carcinoma Feature Absent | Carcinoma, Large Cell | Feature Neuroendocrine | Feature Neuroendocrine Absent | Carcinoma, Neuroendocrine | Bronchioloalveolar carcinoma
Item
1. histological confirmation of non-small cell cancer will be required by either biopsy or cytology. the following primary cancer types are eligible: squamous cell carcinoma, adenocarcinoma with or without bac features, large cell carcinoma with or without neuroendocrine features, neuroendocrine carcinoma, bronchioloalveolar cell carcinoma, or non-small cell carcinoma not otherwise specified.
boolean
C1266002 (UMLS CUI [1])
C0007137 (UMLS CUI [2])
C0001418 (UMLS CUI [3])
C0007120 (UMLS CUI [4,1])
C2348519 (UMLS CUI [4,2])
C0007120 (UMLS CUI [5,1])
C2348519 (UMLS CUI [5,2])
C0332197 (UMLS CUI [5,3])
C0206704 (UMLS CUI [6])
C2348519 (UMLS CUI [7,1])
C0027912 (UMLS CUI [7,2])
C2348519 (UMLS CUI [8,1])
C0027912 (UMLS CUI [8,2])
C0332197 (UMLS CUI [8,3])
C0206695 (UMLS CUI [9])
C0007120 (UMLS CUI [10])
Stage, non-small cell lung cancer
Item
2. eligible patients must have appropriate staging studies identifying them as specific subsets of the revised iascl state ia or ib based on only one of the following combinations of tnm staging:
boolean
C0280217 (UMLS CUI [1])
TNM clinical staging
Item
t1, n0, m0 or t2 (<=4 cm), n0, m0
boolean
C3258246 (UMLS CUI [1])
Hilar lymph node PET/CT scan | Mediastinal lymph nodes PET/CT scan | Hilar lymph node Short axis Diameter | Mediastinal lymph nodes Short axis Diameter
Item
3. a pet/ct scan is required. patients with hilar or mediastinal lymph nodes with short axis diameter < 1 cm and no abnormal hilar or mediastinal uptake on pet will be considered n0. patients with > 1 cm short axis diameter of hilar or mediastinal lymph nodes on ct or abnormal pet (including suspicious but non-diagnostic uptake) may still be eligible if directed tissue biopsy of all abnormally identified areas are negative for cancer. solitary pulmonary lesions <4 mm will not be considered significant.
boolean
C1305372 (UMLS CUI [1,1])
C1699633 (UMLS CUI [1,2])
C0588055 (UMLS CUI [2,1])
C1699633 (UMLS CUI [2,2])
C1305372 (UMLS CUI [3,1])
C0522488 (UMLS CUI [3,2])
C1301886 (UMLS CUI [3,3])
C0588055 (UMLS CUI [4,1])
C0522488 (UMLS CUI [4,2])
C1301886 (UMLS CUI [4,3])
Patients Appropriate Excision Primary tumor | Pulmonary function Excision Non-Small Cell Lung Carcinoma | FEV1 | FEV1 Postoperative | Diffusion capacity of lung | Hypoxemia Absent | Hypercapnia Absent | Exercise Oxygen consumption measurement | Severe pulmonary hypertension Absent | Cerebral disorder Severe Absent | Heart Diseases Severe Absent | Peripheral Vascular Diseases Severe Absent | Chronic heart disease Severe Absent
Item
4. the patients must be considered a reasonable candidate for surgical resection of the primary tumor. standard justification for deeming a patient medically operable based on pulmonary function for surgical resection of nsclc may include any of the following: baseline fev1 > 40% predicted, post-operative predicted fev1 > 30% predicted, diffusion capacity > 40% predicted, absent baseline hypoxemia and/or hypercapnia, exercise oxygen consumption > 50% predicted, absent severe pulmonary hypertension, absent severe cerebral, cardiac, or peripheral vascular disease, and absent severe chronic heart disease.
boolean
C0030705 (UMLS CUI [1,1])
C1548787 (UMLS CUI [1,2])
C0728940 (UMLS CUI [1,3])
C0677930 (UMLS CUI [1,4])
C0231921 (UMLS CUI [2,1])
C0728940 (UMLS CUI [2,2])
C0007131 (UMLS CUI [2,3])
C0849974 (UMLS CUI [3])
C0849974 (UMLS CUI [4,1])
C0032790 (UMLS CUI [4,2])
C0231971 (UMLS CUI [5])
C0700292 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0020440 (UMLS CUI [7,1])
C0332197 (UMLS CUI [7,2])
C0015259 (UMLS CUI [8,1])
C1305742 (UMLS CUI [8,2])
C2750273 (UMLS CUI [9,1])
C0332197 (UMLS CUI [9,2])
C0234387 (UMLS CUI [10,1])
C0205082 (UMLS CUI [10,2])
C0332197 (UMLS CUI [10,3])
C0018799 (UMLS CUI [11,1])
C0205082 (UMLS CUI [11,2])
C0332197 (UMLS CUI [11,3])
C0085096 (UMLS CUI [12,1])
C0205082 (UMLS CUI [12,2])
C0332197 (UMLS CUI [12,3])
C1290386 (UMLS CUI [13,1])
C0205082 (UMLS CUI [13,2])
C0332197 (UMLS CUI [13,3])
Age
Item
5. patients must be ≥ 18 years of age.
boolean
C0001779 (UMLS CUI [1])
Zubrod Performance Status
Item
6. the patient's zubrod performance status must be zubrod 0-2.
boolean
C3714786 (UMLS CUI [1])
Diagnostic Neoplasm Staging mandatory
Item
7. mandatory staging studies: must be done within 8 weeks prior to study entry
boolean
C0027646 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
Informed Consent
Item
8. patients must sign a study-specific consent form.
boolean
C0021430 (UMLS CUI [1])
Females & males of reproductive potential Contraceptive methods
Item
9. patients (men and women) of child bearing potential should use an effective (for them) method of birth control throughout their participation in this study.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Primary tumor Size
Item
1. patients with primary tumors > 4 cm;
boolean
C0677930 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Neuroendocrine Carcinoma Well Differentiated | Carcinoid Tumor Well Differentiated
Item
2. patients with well-differentiated neuroendocrine carcinoma (carcinoid tumor)
boolean
C0206695 (UMLS CUI [1,1])
C0205615 (UMLS CUI [1,2])
C0007095 (UMLS CUI [2,1])
C0205615 (UMLS CUI [2,2])
Neoplasm Metastasis regional | Distant metastasis | Cancer Other | Exception Skin carcinoma | Exception Carcinoma in Situ
Item
3. direct evidence of regional or distant metastases after appropriate staging studies, or synchronous primary or prior malignancy in the past 5 years other than nonmelanomatous skin cancer or in situ cancer;
boolean
C0027627 (UMLS CUI [1,1])
C0205147 (UMLS CUI [1,2])
C1269798 (UMLS CUI [2])
C1707251 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C0699893 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0007099 (UMLS CUI [5,2])
Radiotherapy to lung | Radiotherapy to mediastinum
Item
4. previous lung or mediastinal radiotherapy;
boolean
C0948315 (UMLS CUI [1])
C4049191 (UMLS CUI [2])
Local Therapy Planned | Radiotherapy fractionation | Operative Surgical Procedures | Exception Disease Progression
Item
5. plans for the patient to receive other concomitant local therapy (including standard fractionated radiotherapy and surgery) while on this protocol except at disease progression;
boolean
C1517925 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C3161031 (UMLS CUI [2])
C0543467 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C0242656 (UMLS CUI [4,2])
Pregnancy | Breast Feeding
Item
6. pregnant or lactating women, as treatment involves unforeseeable risks to the embryo or fetus;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Stereotactic Radiotherapy Planning Unsuccessful
Item
7. cannot achieve acceptable srt planning to meet minimal requirement of target coverage and dose-volume constraints of critical structures (see rt techniques).
boolean
C1720823 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C1272705 (UMLS CUI [1,3])