Nasopharyngeal carcinoma WHO tumor classification | Epstein-Barr Virus Associated | EBER Present In Situ Hybridization
Item
histologically or cytologically proven npc of any who grade, associated with ebv documented by the presence of eber by in situ hybridization in the tumor. this must be confirmed by pathology review at brigham and women's hospital.
boolean
C2931822 (UMLS CUI [1,1])
C1301142 (UMLS CUI [1,2])
C0014644 (UMLS CUI [2,1])
C0332281 (UMLS CUI [2,2])
C3830308 (UMLS CUI [3,1])
C0150312 (UMLS CUI [3,2])
C0162788 (UMLS CUI [3,3])
Nasopharyngeal carcinoma incurable | Recurrent disease | Progressive Disease | Therapeutic procedure Initial | Curative treatment Lacking | Metastatic malignant neoplasm to nasopharynx
Item
incurable npc as defined by: relapsed or progressive disease after initial treatment with no potentially curative option; npc with metastasis
boolean
C2931822 (UMLS CUI [1,1])
C0175969 (UMLS CUI [1,2])
C0277556 (UMLS CUI [2])
C1335499 (UMLS CUI [3])
C0087111 (UMLS CUI [4,1])
C0205265 (UMLS CUI [4,2])
C1273390 (UMLS CUI [5,1])
C0332268 (UMLS CUI [5,2])
C1334731 (UMLS CUI [6])
Toxicity Due to Prior Therapy Nasopharyngeal carcinoma | Toxicity CTCAE Grades | Patient recovered
Item
recovery from toxicity from any prior npc therapy to grade 1 or better (ctcace v.3.0)
boolean
C0600688 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C1514463 (UMLS CUI [1,3])
C2931822 (UMLS CUI [1,4])
C0600688 (UMLS CUI [2,1])
C1516728 (UMLS CUI [2,2])
C1115804 (UMLS CUI [3])
Age
Item
18 years of age or older
boolean
C0001779 (UMLS CUI [1])
Evaluable Disease
Item
evaluable disease, according to recist
boolean
C1516986 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status of 0-1
boolean
C1520224 (UMLS CUI [1])
Bone Marrow function | Liver function | Renal function
Item
adequate bone marrow, liver and renal function
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
Therapeutic radiology procedure Nasopharyngeal carcinoma Primary | Therapeutic radiology procedure Reason Any
Item
radiotherapy for primary npc within 8 weeks of enrollment, or radiotherapy for any other reason within 6 weeks
boolean
C1522449 (UMLS CUI [1,1])
C2931822 (UMLS CUI [1,2])
C0205225 (UMLS CUI [1,3])
C1522449 (UMLS CUI [2,1])
C0392360 (UMLS CUI [2,2])
C1552551 (UMLS CUI [2,3])
Chemotherapy Nasopharyngeal carcinoma
Item
chemotherapy for npc within 2 weeks of enrollment
boolean
C0392920 (UMLS CUI [1,1])
C2931822 (UMLS CUI [1,2])
Cancer Other | Exception Carcinoma in situ of uterine cervix | Exception Carcinoma in situ of bladder | Exception Skin carcinoma
Item
other cancer in the past 5 years, except for carcinoma in situ of the cervix or bladder, or non-melanomatous skin cancer
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0851140 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0154091 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0699893 (UMLS CUI [4,2])
CNS metastases Uncontrolled
Item
uncontrolled central nervous system metastases
boolean
C0686377 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Hepatitis | HIV Infections | Condition Requirement Therapeutic immunosuppression | CORTICOSTEROIDS FOR SYSTEMIC USE
Item
acute hepatitis, known hiv, or other condition that requires immunosuppressive therapy, including current use of systemic corticosteroids
boolean
C0019158 (UMLS CUI [1])
C0019693 (UMLS CUI [2])
C0348080 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C0021079 (UMLS CUI [3,3])
C3653708 (UMLS CUI [4])
Autoimmune Disease Treatment required for
Item
autoimmune disease that is active and requires current therapy
boolean
C0004364 (UMLS CUI [1,1])
C0332121 (UMLS CUI [1,2])
Communicable Disease Serious Uncontrolled
Item
active, uncontrolled, serious infection
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
Healing Incomplete | Etiology Major surgery Previous
Item
incomplete healing from previous major surgery
boolean
C0043240 (UMLS CUI [1,1])
C0205257 (UMLS CUI [1,2])
C0015127 (UMLS CUI [2,1])
C0679637 (UMLS CUI [2,2])
C0205156 (UMLS CUI [2,3])
Heart Disease Uncontrolled
Item
significant history of uncontrolled cardiac disease
boolean
C0018799 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Serum pregnancy test (B-HCG) Positive | Breast Feeding
Item
women who have a positive b-hcg test or are breastfeeding
boolean
C0430060 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
C0006147 (UMLS CUI [2])
Chemotherapy Except for Study Protocol | Investigational New Drugs Except for Study Protocol
Item
any concurrent chemotherapy or other concurrent investigational agent not part of this study
boolean
C0392920 (UMLS CUI [1,1])
C0332300 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
C0013230 (UMLS CUI [2,1])
C0332300 (UMLS CUI [2,2])
C2348563 (UMLS CUI [2,3])