Clinically isolated syndrome | Multiple Sclerosis, Acute Relapsing | Multiple Sclerosis, Secondary Progressive
Item
diagnosis of clinically isolated syndrome or a relapsing form(s) of ms, based on poser or mcdonald criteria (may include patients with secondary progressive disease)
boolean
C2921627 (UMLS CUI [1])
C0393664 (UMLS CUI [2])
C0751965 (UMLS CUI [3])
Relapse Clinical | Gadolinium-Enhancing Lesion MRI scan brain
Item
clinical relapse within the past 3 years or a gadolinium enhancing lesion on a brain mri scan within the past 12 months
boolean
C0035020 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C1333400 (UMLS CUI [2,1])
C0412675 (UMLS CUI [2,2])
EDSS
Item
baseline edss score of 0 - 6.5
boolean
C0451246 (UMLS CUI [1])
Gender Sexually active Barrier Contraception Double | Exception Female Sterilization | Exception Postmenopausal state
Item
female subjects who are sexually active, unless sterile or post-menopausal for at least 1 year, must be willing to use double-barrier contraception
boolean
C0079399 (UMLS CUI [1,1])
C0241028 (UMLS CUI [1,2])
C0004764 (UMLS CUI [1,3])
C0205173 (UMLS CUI [1,4])
C1705847 (UMLS CUI [2,1])
C0015787 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0232970 (UMLS CUI [3,2])
Multiple Sclerosis, Primary Progressive
Item
primary progressive ms
boolean
C0751964 (UMLS CUI [1])
Medical condition predisposing Immunocompromised patient
Item
any medical condition that predisposes to immunocompromise
boolean
C3843040 (UMLS CUI [1,1])
C0231203 (UMLS CUI [1,2])
C0085393 (UMLS CUI [1,3])
Malignant Neoplasms | Tuberculosis | Invasive Fungal Infections | Herpes zoster disease | Opportunistic Infections | Communicable Disease
Item
history of malignancy, tuberculosis, invasive fungal infections, herpes zoster infection (or shingles), or other opportunistic infection, or any current active infection
boolean
C0006826 (UMLS CUI [1])
C0041296 (UMLS CUI [2])
C1262313 (UMLS CUI [3])
C0019360 (UMLS CUI [4])
C0029118 (UMLS CUI [5])
C0009450 (UMLS CUI [6])
Autoimmune Disease | Rheumatoid Arthritis | Lupus Erythematosus
Item
concurrent diagnosis of any other autoimmune disease (eg, rheumatoid arthritis or lupus)
boolean
C0004364 (UMLS CUI [1])
C0003873 (UMLS CUI [2])
C0409974 (UMLS CUI [3])
Cyclophosphamide | Mitoxantrone
Item
treatment with cyclophosphamide or mitoxantrone within 6 months of study initiation
boolean
C0010583 (UMLS CUI [1])
C0026259 (UMLS CUI [2])
Cyclosporine | Azathioprine | Methotrexate | Immunosuppressive Agents
Item
treatment with cyclosporine, azathioprine, methotrexate or other immunosuppressant within 3 months of study initiation
boolean
C0010592 (UMLS CUI [1])
C0004482 (UMLS CUI [2])
C0025677 (UMLS CUI [3])
C0021081 (UMLS CUI [4])
Interferon-beta | Glatiramer acetate
Item
treatment with interferon beta or glatiramer acetate within 2 months of study initiation
boolean
C0015980 (UMLS CUI [1])
C0289884 (UMLS CUI [2])
natalizumab | rituximab
Item
prior treatment with natalizumab or rituximab
boolean
C1172734 (UMLS CUI [1])
C0393022 (UMLS CUI [2])