Age
Item
age ≥ 18 years
boolean
C0001779 (UMLS CUI [1])
Multiple Myeloma Durie/Salmon Stage
Item
stage ii-iii multiple myeloma
boolean
C0026764 (UMLS CUI [1,1])
C4528204 (UMLS CUI [1,2])
Recurrent disease | Refractory Disease Primary | Status post Chemotherapy Initial
Item
relapse or primary refractory disease after initial chemotherapy
boolean
C0277556 (UMLS CUI [1])
C1514815 (UMLS CUI [2,1])
C0205225 (UMLS CUI [2,2])
C0231290 (UMLS CUI [3,1])
C0392920 (UMLS CUI [3,2])
C0205265 (UMLS CUI [3,3])
WHO performance status scale
Item
who performance status 0 - 2
boolean
C1298650 (UMLS CUI [1])
Life Expectancy
Item
life expectancy of at least 6 weeks
boolean
C0023671 (UMLS CUI [1])
Absolute neutrophil count | Neoplastic cell infiltration of bone marrow
Item
anc (absolute neutrophil count) ≥ 1.0x109/l(or ≥ 0.5x109/l, if due to bone marrow infiltration by malignancy)
boolean
C0948762 (UMLS CUI [1])
C3670598 (UMLS CUI [2])
Platelet Count measurement | Neoplastic cell infiltration of bone marrow
Item
platelet count ≥ 75x109/l or ≥ 50x109/l, if due to bone marrow infiltration by malignancy)
boolean
C0032181 (UMLS CUI [1])
C3670598 (UMLS CUI [2])
Informed Consent
Item
written informed consent (present in patient's file)
boolean
C0021430 (UMLS CUI [1])
Contraceptive methods Able | Contraceptive methods Willing
Item
patient is able and willing to use adequate contraception during therapy and for at least 1 month after study
boolean
C0700589 (UMLS CUI [1,1])
C0085732 (UMLS CUI [1,2])
C0700589 (UMLS CUI [2,1])
C0600109 (UMLS CUI [2,2])
Comprehension Study Protocol
Item
patient has the ability to understand the requirements of the study
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
Bortezomib
Item
previous treatment with bortezomib
boolean
C1176309 (UMLS CUI [1])
Urine production 24 Hour urine volume measurement
Item
urine production < 1.5 l/24h
boolean
C0683190 (UMLS CUI [1,1])
C0427843 (UMLS CUI [1,2])
Polyneuropathy Pre-existing CTCAE Grades
Item
pre-existent polyneuropathy (grade 2 or higher, according to ctcae 3.0)
boolean
C0152025 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C1516728 (UMLS CUI [1,3])
Pregnancy | Pregnancy test positive
Item
pregnancy or positive pregnancy tests during study and for 1 month after final dose of thalidomide
boolean
C0032961 (UMLS CUI [1])
C0240802 (UMLS CUI [2])
Malignant Neoplasms | Exception Basal cell carcinoma
Item
history of active malignancy during the past 5 years with the exception of basal carcinoma of the skin)
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
Communicable Disease Uncontrolled
Item
active uncontrolled infections
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Disease Serious Uncontrolled | Serious mental illness Uncontrolled
Item
additional uncontrolled serious medical or psychiatric illness
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C3841614 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])