Multiple Myeloma Symptomatic Tumor stage | Multiple Myeloma Progressive Durie/Salmon Stage | Patient need for Chemotherapy | Patient need for Therapeutic radiology procedure | Ineligibility Tandem Hematopoietic Stem Cell Transplantation Study | Ineligibility Total Marrow Irradiation | Disease Documentation International Staging System for Myeloma
Item
multiple myeloma patients with symptomatic disease, stage ii or iii at diagnosis or progressive stage i requiring chemotherapy and/or radiation therapy (by salmon-durie classification), who are not eligible for tandem transplant study using tmi; because of previous radiation or eligibility criteria; documentation of disease staging by both salmon-durie classification and international staging system (iss) is required
boolean
C0026764 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C1300072 (UMLS CUI [1,3])
C0026764 (UMLS CUI [2,1])
C0205329 (UMLS CUI [2,2])
C4528204 (UMLS CUI [2,3])
C0686904 (UMLS CUI [3,1])
C0392920 (UMLS CUI [3,2])
C0686904 (UMLS CUI [4,1])
C1522449 (UMLS CUI [4,2])
C1512714 (UMLS CUI [5,1])
C3897372 (UMLS CUI [5,2])
C2603343 (UMLS CUI [5,3])
C1512714 (UMLS CUI [6,1])
C2348809 (UMLS CUI [6,2])
C0012634 (UMLS CUI [7,1])
C0920316 (UMLS CUI [7,2])
C2346508 (UMLS CUI [7,3])
Non-secretory myeloma | Serum Free Immunoglobulin Light Chain Measurable | Other Coding | Measurable Disease | Soft tissue Myeloma
Item
patients with non-secretory myeloma should have measurable serum free-light chain protein by the free-lite test or measurable disease such as a soft tissue myeloma
boolean
C0456845 (UMLS CUI [1])
C2827352 (UMLS CUI [2,1])
C1513040 (UMLS CUI [2,2])
C3846158 (UMLS CUI [3])
C1513041 (UMLS CUI [4])
C0225317 (UMLS CUI [5,1])
C0026764 (UMLS CUI [5,2])
Minimum Cell positive for CD34 antigen Quantity Per Kilogram
Item
a minimum of 4 x 10^6 of cd 34 positive cell/kg has been harvested
boolean
C1524031 (UMLS CUI [1,1])
C0882849 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C4054209 (UMLS CUI [1,4])
Karnofsky Performance Status | Exception Impairment Due to Bone Diseases
Item
a karnofsky performance status (kps) of >= 70% is required unless the kps is impaired due to bone disease
boolean
C0206065 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0221099 (UMLS CUI [2,2])
C0678226 (UMLS CUI [2,3])
C0005940 (UMLS CUI [2,4])
Medical contraindication Absent Collection Cell positive for CD34 antigen | Cell positive for CD34 antigen Quantity Per Kilogram Apheresis
Item
no contraindication to the collection of a minimum of 4 x 10^6 cd34+ cells/kg by apheresis
boolean
C1301624 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0200345 (UMLS CUI [1,3])
C0882849 (UMLS CUI [1,4])
C0882849 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C4054209 (UMLS CUI [2,3])
C0005791 (UMLS CUI [2,4])
Informed Consent
Item
all patients must have signed a voluntary, informed consent in accordance with institutional and federal guidelines
boolean
C0021430 (UMLS CUI [1])
Serum total bilirubin measurement
Item
bilirubin =< 1.5 mg/dl
boolean
C1278039 (UMLS CUI [1])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
serum glutamic oxaloacetic transaminase (sgot) and serum glutamic pyruvate transaminase (sgpt) < 2.5 x upper limits of normal
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Creatinine clearance measurement
Item
creatinine clearance of >= 40cc/min
boolean
C0373595 (UMLS CUI [1])
Absolute neutrophil count
Item
absolute neutrophil count of > 1000/ul
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
platelet count of > 100,000/ul
boolean
C0032181 (UMLS CUI [1])
Cardiac ejection fraction MUGA scan | Cardiac ejection fraction Echocardiography
Item
cardiac ejection fraction >= 45% by multigated acquisition (muga) scan and/or by echocardiogram
boolean
C0232174 (UMLS CUI [1,1])
C0521317 (UMLS CUI [1,2])
C0232174 (UMLS CUI [2,1])
C0013516 (UMLS CUI [2,2])
Carbon Monoxide Diffusing Capability Test
Item
diffusing capacity of the lung for carbon monoxide (dlco) >= 50% of predicted lower limit
boolean
C1516251 (UMLS CUI [1])
HIV antibody negative
Item
human immunodeficiency virus (hiv) antibody tests negative
boolean
C1142096 (UMLS CUI [1])
Patient Problem Absent | Psychosocial problem Absent | High risk Due to Therapeutic procedure
Item
no other medical, or psychosocial problems which in the opinion of the primary physician or principal investigator would place the patient at unacceptably high risk from this treatment regimen
boolean
C1254481 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0740697 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0332167 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0087111 (UMLS CUI [3,3])
Peripheral Neuropathy CTCAE Grades
Item
presence of peripheral neuropathy >= grade ii
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Disease Progression | Increase M Protein Percentage | Bortezomib | Thalidomide
Item
patients with evidence of disease progression (with >= 25% increase in m protein) on bortezomib and or thalidomide therapy prior to transplant
boolean
C0242656 (UMLS CUI [1])
C0442805 (UMLS CUI [2,1])
C0700271 (UMLS CUI [2,2])
C0439165 (UMLS CUI [2,3])
C1176309 (UMLS CUI [3])
C0039736 (UMLS CUI [4])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Double Unwilling | Gender Male Condoms Unwilling
Item
pregnant or nursing women, as well as women of child bearing age, who are unwilling to use a dual method of contraception and men who are unwilling to use condom
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0205173 (UMLS CUI [3,3])
C0558080 (UMLS CUI [3,4])
C0079399 (UMLS CUI [4,1])
C0009653 (UMLS CUI [4,2])
C0558080 (UMLS CUI [4,3])
Hypersensitivity Bortezomib | Hypersensitivity Boron | Mannitol allergy
Item
patients with history of hypersensitivity to bortezomib, boron or mannitol
boolean
C0020517 (UMLS CUI [1,1])
C1176309 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0006030 (UMLS CUI [2,2])
C0571922 (UMLS CUI [3])