Essential Hypertension Mild Grade | Essential Hypertension Moderate Grade | Sitting systolic blood pressure mean Patient Visit Quantity | Sitting diastolic blood pressure mean Patient Visit Quantity
Item
patients with mild to moderate essential hypertension (grade i and grade ii) with mean sitting office sbp =140-179 mmhg and/or mean sitting office dbp = 90 -109 mmhg on 2 consecutive visits (screening and v1).
boolean
C0085580 (UMLS CUI [1,1])
C2945599 (UMLS CUI [1,2])
C0441800 (UMLS CUI [1,3])
C0085580 (UMLS CUI [2,1])
C0205081 (UMLS CUI [2,2])
C0441800 (UMLS CUI [2,3])
C1319893 (UMLS CUI [3,1])
C0444504 (UMLS CUI [3,2])
C1512346 (UMLS CUI [3,3])
C1265611 (UMLS CUI [3,4])
C1319894 (UMLS CUI [4,1])
C0444504 (UMLS CUI [4,2])
C1512346 (UMLS CUI [4,3])
C1265611 (UMLS CUI [4,4])
Blood pressure determination Daytime | Blood Pressure Monitoring, Ambulatory | Systolic Pressure
Item
daytime blood pressure above threshold for definition of hypertension in the baseline abpm measurement (sbp >135 mmhg).
boolean
C0005824 (UMLS CUI [1,1])
C0332169 (UMLS CUI [1,2])
C0242876 (UMLS CUI [2])
C0871470 (UMLS CUI [3])
Stable blood pressure Patient Visit Quantity | Change Amount Sitting systolic blood pressure | Change Amount Sitting diastolic blood pressure mean
Item
stable baseline blood pressure confirmed on 2 consecutive visits (screening and v1). (changes <20mmhg for sitting office sbp and <10mmhg for mean sitting office dpb).
boolean
C0428896 (UMLS CUI [1,1])
C1512346 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0392747 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1319893 (UMLS CUI [2,3])
C0392747 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C1319894 (UMLS CUI [3,3])
C0444504 (UMLS CUI [3,4])
Antihypertensive therapy Absent | Antihypertensive therapy Previous | Stop medication Possible
Item
patients without current antihypertensive therapy. patients on previous mono-antihypertensive therapy, who can safely stop their medication
boolean
C0585941 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0585941 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
C0850893 (UMLS CUI [3,1])
C0332149 (UMLS CUI [3,2])
Protocol Compliance
Item
patient is willing and able to comply with all trial requirements and procedures.
boolean
C0525058 (UMLS CUI [1])
Hypertensive disease Grade | Sitting systolic blood pressure mean
Item
patients with "very high added risk" according to 2007 guidelines for the management of arterial hypertension (journal of hypertension, 2007, 25:1105- 1187), i.e. those with:grade iii hypertension (mean sitting office sbp
boolean
C0020538 (UMLS CUI [1,1])
C0441800 (UMLS CUI [1,2])
C1319893 (UMLS CUI [2,1])
C0444504 (UMLS CUI [2,2])
Sitting diastolic blood pressure mean | Cardiovascular Disease Established | Kidney Disease Established | Ischemic stroke | Cerebral Hemorrhage | Transient Ischemic Attack | Myocardial Infarction | Angina Pectoris | Coronary revascularisation | Heart failure New York Heart Association Classification
Item
180mmhg and/or meansitting dbp ≥110mmhg/history or presence of established cardiovascular or renal disease (ischemic stroke, cerebral hemorrhage, transient ischemic attack)/ myocardial infarction, angina pectoris, coronary re-vascularization/ clinically relevant heart failure (nyha class ii-iv)/
boolean
C1319894 (UMLS CUI [1,1])
C0444504 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2,1])
C0443211 (UMLS CUI [2,2])
C0022658 (UMLS CUI [3,1])
C0443211 (UMLS CUI [3,2])
C0948008 (UMLS CUI [4])
C2937358 (UMLS CUI [5])
C0007787 (UMLS CUI [6])
C0027051 (UMLS CUI [7])
C0002962 (UMLS CUI [8])
C0877341 (UMLS CUI [9])
C0018801 (UMLS CUI [10,1])
C1275491 (UMLS CUI [10,2])
Peripheral Arterial Diseases | Diabetic Nephropathy
Item
peripheral artery disease/ diabetic nephropathy
boolean
C1704436 (UMLS CUI [1])
C0011881 (UMLS CUI [2])
Left Ventricular Hypertrophy Electrocardiography
Item
electrocardiographic confirmed left ventricular hypertrophy
boolean
C0149721 (UMLS CUI [1,1])
C1623258 (UMLS CUI [1,2])
Plasma creatinine increased
Item
increased plasma creatinine
boolean
C0858118 (UMLS CUI [1])
Diabetes Mellitus, Insulin-Dependent | Diabetes Mellitus, Non-Insulin-Dependent | Non-Insulin-Dependent Diabetes Mellitus New diagnosis
Item
diabetes mellitus type i, history, presence or new diagnosis of diabetes mellitus type ii.
boolean
C0011854 (UMLS CUI [1])
C0011860 (UMLS CUI [2])
C0011860 (UMLS CUI [3,1])
C2585997 (UMLS CUI [3,2])
Hypotension, Orthostatic
Item
postural hypotension at screening
boolean
C0020651 (UMLS CUI [1])
Cardiac Arrhythmia Interferes with Oscillometry Blood Pressure
Item
arrhythmias that would interfere with the oscilloscopic measurement of the blood pressure.
boolean
C0003811 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0029375 (UMLS CUI [1,3])
C0005823 (UMLS CUI [1,4])
Autoimmune Diseases
Item
known autoimmune disease.
boolean
C0004364 (UMLS CUI [1])
Severe allergy
Item
severe allergy.
boolean
C2945656 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnancy or breastfeeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Childbearing Potential Female Sterilization Absent
Item
women in childbearing age that are not surgically sterilized.
boolean
C3831118 (UMLS CUI [1,1])
C0015787 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
HIV Seropositivity | Immunosuppression Positive | Hepatitis B positive | Hepatitis C positive
Item
patients with a history or current positive test for hiv infection, aids, or other immunosuppressive disorders; hepatitis b or c.
boolean
C0019699 (UMLS CUI [1])
C4048329 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
C0856706 (UMLS CUI [3])
C1112419 (UMLS CUI [4])
Malignant Neoplasms
Item
current diagnosis or history of malignancy.
boolean
C0006826 (UMLS CUI [1])