Age
Item
age ≥ 18 years
boolean
C0001779 (UMLS CUI [1])
Colorectal cancer metastatic
Item
histologically confirmed metastatic colorectal cancer (crc)
boolean
C0948380 (UMLS CUI [1])
Availability of Tumor tissue sample Paraffin Block | Availability of Unstained Specimen Quantity | Pathology report
Item
representative tumor specimens in paraffin blocks (preferred) or at least 15 unstained slides, with an associated pathology report, must be confirmed to be available and requested at any time prior to entry of study
boolean
C0470187 (UMLS CUI [1,1])
C0475358 (UMLS CUI [1,2])
C1519524 (UMLS CUI [1,3])
C0470187 (UMLS CUI [2,1])
C1883469 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0807321 (UMLS CUI [3])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status 0 or 1
boolean
C1520224 (UMLS CUI [1])
Capacity Hematopoietic
Item
adequate hematopoetic capacity
boolean
C1516240 (UMLS CUI [1,1])
C0229601 (UMLS CUI [1,2])
Liver function
Item
adequate hepatic function
boolean
C0232741 (UMLS CUI [1])
Renal function
Item
adequate renal function
boolean
C0232804 (UMLS CUI [1])
Childbearing Potential Barrier Contraception
Item
use of an effective method of barrier contraception (for women of childbearing potential)
boolean
C3831118 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
Informed Consent
Item
signed informed consent
boolean
C0021430 (UMLS CUI [1])
Prior Chemotherapy Colorectal cancer metastatic | Adjuvant Chemotherapy Colorectal Carcinoma
Item
prior chemotherapy for metastatic crc or adjuvant chemotherapy for crc within the prior 6 months
boolean
C1514457 (UMLS CUI [1,1])
C0948380 (UMLS CUI [1,2])
C0085533 (UMLS CUI [2,1])
C0009402 (UMLS CUI [2,2])
CNS metastases Suspected | CNS metastases | Meningeal Carcinomatosis Suspected | Meningeal Carcinomatosis
Item
clinically suspected or confirmed cns metastases or carcinomatous meningitis
boolean
C0686377 (UMLS CUI [1,1])
C0750491 (UMLS CUI [1,2])
C0686377 (UMLS CUI [2])
C0220654 (UMLS CUI [3,1])
C0750491 (UMLS CUI [3,2])
C0220654 (UMLS CUI [4])
Major surgery
Item
major surgical procedure within 4 weeks prior to the first day of treatment in this study (day 1)
boolean
C0679637 (UMLS CUI [1])
Irradiation of pelvis
Item
pelvic radiation within 2 weeks prior to day 1
boolean
C0747411 (UMLS CUI [1])
Wound dehiscence Requirement Intervention | Gastrointestinal perforation | Intestinal Obstruction
Item
wound dehiscence requiring intervention, gastrointestinal perforation, or bowel obstruction
boolean
C0259768 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0184661 (UMLS CUI [1,3])
C0151664 (UMLS CUI [2])
C0021843 (UMLS CUI [3])
Pregnancy | Lactation
Item
pregnancy or lactation
boolean
C0032961 (UMLS CUI [1])
C0022925 (UMLS CUI [2])
Illness Uncontrolled | Communicable Disease Requirement Antibiotics Intravenous | Congestive heart failure Uncontrolled | Uncontrolled hypertension
Item
uncontrolled medical illnesses including the following: infection requiring intravenous (iv) antibiotics, congestive heart failure not controlled with medication, hypertension not controlled with medication
boolean
C0221423 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0003232 (UMLS CUI [2,3])
C1522726 (UMLS CUI [2,4])
C0018802 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C1868885 (UMLS CUI [4])
Thromboembolism
Item
thromboembolic disease
boolean
C0040038 (UMLS CUI [1])
Comorbidity | Dysfunction Metabolic | Physical Examination Finding | Laboratory test finding | Medical contraindication Investigational New Drugs | Condition Affecting Interpretation Research results | Condition High risk of Complications of treatment
Item
history of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates use of an investigational drug or that might affect interpretation of the results of the study or render the patient at high risk from treatment complications
boolean
C0009488 (UMLS CUI [1])
C3887504 (UMLS CUI [2,1])
C0311400 (UMLS CUI [2,2])
C0031809 (UMLS CUI [3,1])
C0243095 (UMLS CUI [3,2])
C0587081 (UMLS CUI [4])
C1301624 (UMLS CUI [5,1])
C0013230 (UMLS CUI [5,2])
C0348080 (UMLS CUI [6,1])
C0392760 (UMLS CUI [6,2])
C0459471 (UMLS CUI [6,3])
C0683954 (UMLS CUI [6,4])
C0348080 (UMLS CUI [7,1])
C0332167 (UMLS CUI [7,2])
C0679861 (UMLS CUI [7,3])