Age | Major depressive episode Duration
Item
1. patients will be 20 males or females above the age of 18 with a current major depressive episode, as defined by dsm-iv and assessed on the mini, of at least 4 weeks duration.
boolean
C0001779 (UMLS CUI [1])
C0024517 (UMLS CUI [2,1])
C0449238 (UMLS CUI [2,2])
Epilepsy | Requirement Antiepileptic Agents
Item
2. all subjects must have epilepsy, defined as the recurrence of seizures that are unprovoked and unpredictable, requiring treatment with an anti-epileptic medication under the care of a neurologist.
boolean
C0014544 (UMLS CUI [1])
C1514873 (UMLS CUI [2,1])
C0003299 (UMLS CUI [2,2])
Antiepileptic Agents Stabilized
Item
3. subjects must be stabilized on their antiepileptic drug (aed) regimen for the previous 2 months.
boolean
C0003299 (UMLS CUI [1,1])
C0184512 (UMLS CUI [1,2])
Insertion of vagal nerve stimulator | Setting unchanged
Item
4. if a vagus nerve stimulator is in place, the settings must be unchanged for the previous 2 months.
boolean
C2919763 (UMLS CUI [1])
C0815184 (UMLS CUI [2,1])
C0442739 (UMLS CUI [2,2])
Age | Hamilton Depression Rating Scale-24 Item Clinical Classification
Item
5. patients must be ages 18 - 75 and have a 24 item hamilton depression rating scale score (ham-d) at intake >/= 20.
boolean
C0001779 (UMLS CUI [1])
C4330187 (UMLS CUI [2])
Able to speak fluently English Language | Informed Consent
Item
6. subjects must be fluent in english and have the capacity to understand the nature of the study and sign the written informed consent.
boolean
C0564241 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2])
Axis II diagnosis | Antisocial Personality Disorder | Schizotypal Personality Disorder | Borderline Personality Disorder Severe | High risk Completion of clinical trial Unable | Hospitalization | Suicide attempt | Self Mutilation | Self-Injurious Behavior | Destructive behavior
Item
1. axis ii diagnosis of antisocial, schizotypal or severe borderline personality disorder(defined as patients who are high risk for being unable to complete the study due to hospitalization, suicide attempts, significant self-mutilation, or other self-injurious or destructive behavior).
boolean
C0270288 (UMLS CUI [1])
C0003431 (UMLS CUI [2])
C0036363 (UMLS CUI [3])
C0006012 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])
C0332167 (UMLS CUI [5,1])
C2732579 (UMLS CUI [5,2])
C1299582 (UMLS CUI [5,3])
C0019993 (UMLS CUI [6])
C0038663 (UMLS CUI [7])
C0036601 (UMLS CUI [8])
C0085271 (UMLS CUI [9])
C0233520 (UMLS CUI [10])
Psychotic Disorders | Mania | Hypomania
Item
2. history of psychosis, mania or hypomania.
boolean
C0033975 (UMLS CUI [1])
C0338831 (UMLS CUI [2])
C0241934 (UMLS CUI [3])
Seizures Quantity per month | Disturbance of consciousness | Complex partial seizures | Generalized seizures
Item
3. subjects with more than 10 seizures per month that involve impairment of consciousness, such as complex partial or generalized seizures.
boolean
C0036572 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0439507 (UMLS CUI [1,3])
C0234428 (UMLS CUI [2])
C0149958 (UMLS CUI [3])
C0234533 (UMLS CUI [4])
Seizures Count Unable
Item
4. subjects unable to count seizures accurately, or do not have a someone in their home who can count seizures accurately .
boolean
C0036572 (UMLS CUI [1,1])
C0750480 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
Disease Unstable | Nervous system disorder Unstable | Exception Epilepsy
Item
5. unstable medical or neurological disorder (other than epilepsy).
boolean
C0012634 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0027765 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0014544 (UMLS CUI [3,2])
Epilepsy Relationship Nervous system disorder Progressive
Item
6. epilepsies related to a progressive neurologic disease such as a brain tumor.
boolean
C0014544 (UMLS CUI [1,1])
C0439849 (UMLS CUI [1,2])
C0027765 (UMLS CUI [1,3])
C0205329 (UMLS CUI [1,4])
Substance Use Disorders
Item
7. substance abuse including etoh within the past 6 months.
boolean
C0038586 (UMLS CUI [1])
Patient need for Psychotropic Drugs | Exception Antiepileptic Agents | Exception Zolpidem Sleep
Item
8. need for concurrent psychotropic drugs with the exception of aeds or zolpidem for sleep.
boolean
C0686904 (UMLS CUI [1,1])
C0033978 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0003299 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0078839 (UMLS CUI [3,2])
C0037313 (UMLS CUI [3,3])
Psychotherapy New
Item
9. concurrent or recent (within 3 months) entry into a new psychotherapy.
boolean
C0033968 (UMLS CUI [1,1])
C0205314 (UMLS CUI [1,2])
Suicidal
Item
10. actively or acutely suicidal.
boolean
C0438696 (UMLS CUI [1])
Escitalopram | Response failed | Antidepressive Agents | Attempt Quantity failed
Item
11. failure to respond to escitalopram or to two or more other adequate antidepressant trials in the past year.
boolean
C1099456 (UMLS CUI [1])
C1704632 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
C0003289 (UMLS CUI [3])
C1516084 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
C0231175 (UMLS CUI [4,3])
Pregnancy | Breast Feeding
Item
12. pregnancy or lactation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Childbearing Potential Contraceptive methods Absent
Item
13. females of child bearing potential who do not practice adequate contraception.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])