Solid Neoplasm | Malignant lymphoma, metastatic | Lymphoma unresectable | Absence Standard of Care Curative | Standard Palliative Care Absent | Standard of Care Curative ineffective | Standard Palliative Care ineffective
Item
confirmed solid malignancy or lymphoma that is metastatic or unresectable, and for which standard curative or palliative measures do not exist or are no longer effective
boolean
C0280100 (UMLS CUI [1])
C1266190 (UMLS CUI [2])
C0024299 (UMLS CUI [3,1])
C1519810 (UMLS CUI [3,2])
C0332197 (UMLS CUI [4,1])
C2936643 (UMLS CUI [4,2])
C1276305 (UMLS CUI [4,3])
C1442989 (UMLS CUI [5,1])
C0030231 (UMLS CUI [5,2])
C0332197 (UMLS CUI [5,3])
C2936643 (UMLS CUI [6,1])
C1276305 (UMLS CUI [6,2])
C3242229 (UMLS CUI [6,3])
C1442989 (UMLS CUI [7,1])
C0030231 (UMLS CUI [7,2])
C3242229 (UMLS CUI [7,3])
ECOG performance status
Item
performance status (based on the eastern cooperative oncology group assessments) of <= 2
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy > 3 months
boolean
C0023671 (UMLS CUI [1])
Gastrointestinal Absorption Status
Item
adequate gastrointestinal absorption status
boolean
C3714657 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
Liver function | Renal function | Bone Marrow function
Item
adequate liver, kidney and bone marrow function
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0005953 (UMLS CUI [3,1])
C0031843 (UMLS CUI [3,2])
Cardiac function | Left ventricular ejection fraction
Item
adequate heart function (left ventricular ejection fraction >= 50%)
boolean
C0232164 (UMLS CUI [1])
C0428772 (UMLS CUI [2])
Metastatic malignant neoplasm to brain
Item
known brain metastases
boolean
C0220650 (UMLS CUI [1])
Chemotherapy | Nitrosourea | Mitomycin | Therapeutic radiology procedure | Immunotherapy | Investigational New Drugs
Item
chemotherapy (in the case of nitrosoureas and mitomycin c within 6 weeks), radiotherapy, immunotherapy or treatment with an investigational agent within 4 weeks before study drug administration
boolean
C0392920 (UMLS CUI [1])
C0028210 (UMLS CUI [2])
C0002475 (UMLS CUI [3])
C1522449 (UMLS CUI [4])
C0021083 (UMLS CUI [5])
C0013230 (UMLS CUI [6])
Heart Disease Uncontrolled | Uncontrolled hypertension
Item
history of uncontrolled heart disease or uncontrolled arterial hypertension (protocol-defined)
boolean
C0018799 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C1868885 (UMLS CUI [2])
Pharmaceutical Preparations At risk Cardiac function Abnormality
Item
patients taking medications known to have a risk of causing heart function abnormalities (i.e.
boolean
C0013227 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0232164 (UMLS CUI [1,3])
C1704258 (UMLS CUI [1,4])
Prolonged QTc | Torsades de Pointes
Item
qtc prolongation and torsades de pointes)
boolean
C1969409 (UMLS CUI [1])
C0040479 (UMLS CUI [2])
Neuropathy CTCAE Grades
Item
neuropathy (malfunction of the nerves) at baseline of grade > = 2
boolean
C0442874 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Serology positive Hepatitis B | Serology positive Hepatitis C | HIV Seropositivity
Item
positive serology for hepatitis b, hepatitis c or human immunodeficiency virus (hiv)
boolean
C0242089 (UMLS CUI [1,1])
C0019163 (UMLS CUI [1,2])
C0242089 (UMLS CUI [2,1])
C0019196 (UMLS CUI [2,2])
C0019699 (UMLS CUI [3])