Acute Promyelocytic Leukemia Bone Marrow Examination
Item
morphologically confirmed acute promyelocytic leukemia (apl) based on bone marrow examination
boolean
C0023487 (UMLS CUI [1,1])
C0005957 (UMLS CUI [1,2])
Exclusion Other Coding RT PCR
Item
apl-rarα-negative by rt-pcr are not eligible
boolean
C2828389 (UMLS CUI [1,1])
C3846158 (UMLS CUI [1,2])
C0599161 (UMLS CUI [1,3])
Disease High risk | White Blood Cell Count procedure
Item
high-risk disease, defined as wbc > 100,000/mm^3
boolean
C0012634 (UMLS CUI [1,1])
C0332167 (UMLS CUI [1,2])
C0023508 (UMLS CUI [2])
Bone marrow specimen Available Cytogenetic procedure
Item
bone marrow specimens must be made available for cytogenetic studies
boolean
C0438737 (UMLS CUI [1,1])
C0470187 (UMLS CUI [1,2])
C0200896 (UMLS CUI [1,3])
Client Characteristics
Item
patient characteristics:
boolean
C0815172 (UMLS CUI [1])
Pregnancy Absent | Breast Feeding Absent
Item
not pregnant or nursing
boolean
C0032961 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0006147 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Pregnancy test negative
Item
negative pregnancy test
boolean
C0427780 (UMLS CUI [1])
Fertility Contraceptive methods
Item
fertile patients must use effective contraception
boolean
C0015895 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Exclusion Prolonged QTc
Item
no prolonged qtc > 0.47 sec
boolean
C2828389 (UMLS CUI [1,1])
C1969409 (UMLS CUI [1,2])
Exclusion Cancer Other | Exception Basal cell carcinoma Treated | Exception Squamous cell carcinoma of skin Treated | Exception Carcinoma in situ of uterine cervix | Exception Malignant Neoplasms Treated TNM clinical staging | Exception Malignant Neoplasms In complete remission
Item
no other malignancy within the past 5 years, except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated stage i or stage ii cancer from which the patients is currently in complete remission
boolean
C2828389 (UMLS CUI [1,1])
C1707251 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1522326 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0006826 (UMLS CUI [5,2])
C1522326 (UMLS CUI [5,3])
C3258246 (UMLS CUI [5,4])
C1705847 (UMLS CUI [6,1])
C0006826 (UMLS CUI [6,2])
C0677874 (UMLS CUI [6,3])
Therapeutic procedure
Item
prior concurrent therapy:
boolean
C0087111 (UMLS CUI [1])
Exclusion Systemic Chemotherapy Leukemia
Item
no prior systemic chemotherapy for acute leukemia
boolean
C2828389 (UMLS CUI [1,1])
C1883256 (UMLS CUI [1,2])
C0023418 (UMLS CUI [1,3])
Tretinoin Previous
Item
at least 3 days since prior tretinoin (atra) allowed
boolean
C0040845 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
Hydroxyurea Previous | Adrenal Cortex Hormones Previous | Leukapheresis Previous | Control Cell Count High
Item
prior hydroxyurea, corticosteroids, or leukapheresis to control high cell counts allowed
boolean
C0020402 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0001617 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
C0023416 (UMLS CUI [3,1])
C0205156 (UMLS CUI [3,2])
C0243148 (UMLS CUI [4,1])
C0007584 (UMLS CUI [4,2])
C0205250 (UMLS CUI [4,3])