Inclusion criteria Healthy Control
Item
inclusion criteria for lean, healthy control subjects:
boolean
C1512693 (UMLS CUI [1,1])
C2986479 (UMLS CUI [1,2])
Plasma fasting glucose measurement
Item
1. fasting plasma glucose (fpg) < 100
boolean
C0583513 (UMLS CUI [1])
Age
Item
2. age 18 to 55
boolean
C0001779 (UMLS CUI [1])
Body mass index
Item
3. bmi 18.5 to 24.9 kg/m2
boolean
C1305855 (UMLS CUI [1])
Stable body weight
Item
4. stable weight for prior 3 months
boolean
C0517386 (UMLS CUI [1])
Inclusion criteria Prediabetic state
Item
inclusion criteria for prediabetic individuals:
boolean
C1512693 (UMLS CUI [1,1])
C0362046 (UMLS CUI [1,2])
Plasma fasting glucose measurement
Item
1. based on american diabetes association criteria of fpg > 100 and <126
boolean
C0583513 (UMLS CUI [1])
Age
Item
2. age 18 to 55
boolean
C0001779 (UMLS CUI [1])
Body mass index
Item
3. bmi 35 to 60 kg/m2
boolean
C1305855 (UMLS CUI [1])
Stable body weight
Item
4. stable weight for prior 3 months
boolean
C0517386 (UMLS CUI [1])
Inclusion criteria Diabetics
Item
inclusion criteria for diabetic individuals:
boolean
C1512693 (UMLS CUI [1,1])
C0241863 (UMLS CUI [1,2])
Non-Insulin-Dependent Diabetes Mellitus Disease length
Item
1. diagnosis of type 2 diabetes mellitus (t2dm) for < 5 years
boolean
C0011860 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
Hemoglobin A1c measurement
Item
2. hemoglobin a1c < 8%
boolean
C0474680 (UMLS CUI [1])
Age
Item
3. age 18 to 55
boolean
C0001779 (UMLS CUI [1])
Body mass index
Item
4. bmi 35 to 60 kg/m2
boolean
C1305855 (UMLS CUI [1])
Stable body weight
Item
5. stable weight for prior 3 months
boolean
C0517386 (UMLS CUI [1])
Exclusion Criteria Study Subject All
Item
exclusion criteria for all study subjects:
boolean
C0680251 (UMLS CUI [1,1])
C0681850 (UMLS CUI [1,2])
C0444868 (UMLS CUI [1,3])
Thiazolidinediones | Dipeptidyl-Peptidase IV Inhibitors | Sitagliptin | GLP-1 Analogs | Exenatide
Item
1. use of any of the following medications: thiazolidinediones, dipeptidyl-peptidase iv (dpp-iv) inhibitors (e.g., sitagliptin), glp-1 analogs (e.g., exenatide).
boolean
C1257987 (UMLS CUI [1])
C1827106 (UMLS CUI [2])
C1565750 (UMLS CUI [3])
C0061355 (UMLS CUI [4,1])
C0243071 (UMLS CUI [4,2])
C0167117 (UMLS CUI [5])
Diabetes Mellitus, Non-Insulin-Dependent | Poor glycemic control | Fasting blood glucose measurement | Antidiabetics Oral Discontinued | Insulin regime Inappropriate
Item
2. subjects with t2dm who are unable to maintain adequate glycemic control (i.e., having a fasting blood glucose that exceeds 250mg/dl on two consecutive tests) while temporarily discontinuing their oral diabetes medications for the study and in whom the study physician determines insulin therapy would not be appropriate.
boolean
C0011860 (UMLS CUI [1])
C0342299 (UMLS CUI [2])
C0428568 (UMLS CUI [3])
C0935929 (UMLS CUI [4,1])
C1527415 (UMLS CUI [4,2])
C1444662 (UMLS CUI [4,3])
C0557978 (UMLS CUI [5,1])
C1548788 (UMLS CUI [5,2])
Pregnancy test positive
Item
3. females with a positive pregnancy test
boolean
C0240802 (UMLS CUI [1])
Operation on stomach | Duodenal surgery | Jejunal surgery Proximal | Pancreatectomy | Malabsorption Syndrome | Malignant Neoplasms | Renal Insufficiency | Creatinine measurement, serum | Elevated liver enzymes | Warfarin | Clopidogrel | Communicable Diseases | Medical contraindication Nasogastric tube | Medical contraindication Nasojejunal Tubes | Nasal septum abnormality | Upper gastrointestinal hemorrhage | Easy bleeding | Residence Remote
Item
5. prior gastric, duodenal, proximal jejunal surgery or pancreas resection 6. known malabsorptive disorder 7. history of cancer in past 5 years 8. renal insufficiency defined by serum creatinine > 1.5 mg/dl 9. hepatic enzyme elevations of greater than twice the upper limits of normal 10. current use of warfarin or clopidogrel 11. intercurrent infections 12. contraindication to nasogastric or nasojejunal feeding tube (e.g., deviated nasal septum, prior upper gastrointestinal bleed, or history of easy bleeding) 13. residence outside the greater nashville, tn area
boolean
C0192398 (UMLS CUI [1])
C3837072 (UMLS CUI [2])
C3837064 (UMLS CUI [3,1])
C0205107 (UMLS CUI [3,2])
C0030279 (UMLS CUI [4])
C0024523 (UMLS CUI [5])
C0006826 (UMLS CUI [6])
C1565489 (UMLS CUI [7])
C0201976 (UMLS CUI [8])
C0235996 (UMLS CUI [9])
C0043031 (UMLS CUI [10])
C0070166 (UMLS CUI [11])
C0009450 (UMLS CUI [12])
C1301624 (UMLS CUI [13,1])
C0085678 (UMLS CUI [13,2])
C1301624 (UMLS CUI [14,1])
C0184148 (UMLS CUI [14,2])
C0151790 (UMLS CUI [15])
C0041909 (UMLS CUI [16])
C2199604 (UMLS CUI [17])
C0237096 (UMLS CUI [18,1])
C0205157 (UMLS CUI [18,2])