Age | Diffuse large B-cell lymphoma recurrent | Diffuse large B-cell lymphoma refractory | Status post Therapeutic procedure Initial
Item
male or female patients who are 18 years of age or older with diffuse large b-cell cell lymphoma (dlbcl) relapsed or refractory after initial therapy who:
boolean
C0001779 (UMLS CUI [1])
C0855111 (UMLS CUI [2])
C0855112 (UMLS CUI [3])
C0231290 (UMLS CUI [4,1])
C0087111 (UMLS CUI [4,2])
C0205265 (UMLS CUI [4,3])
Patients Inappropriate Autologous hematopoietic stem cell transplant
Item
are not candidates for autologous stem cell transplant.
boolean
C0030705 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C2193200 (UMLS CUI [1,3])
Recurrent disease Post Autologous hematopoietic stem cell transplant | Recurrent disease Post Allogeneic Stem Cell Transplantation
Item
have relapsed after autologous or allogeneic stem cell transplant.
boolean
C0277556 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C2193200 (UMLS CUI [1,3])
C0277556 (UMLS CUI [2,1])
C0687676 (UMLS CUI [2,2])
C2242529 (UMLS CUI [2,3])
Recurrent disease Post Chemotherapy Regimen Quantity | Refractory Disease Post Chemotherapy Regimen Quantity
Item
have relapsed or refractory disease after 3 successive chemotherapy regimens.
boolean
C0277556 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C0392920 (UMLS CUI [1,3])
C1265611 (UMLS CUI [1,4])
C1514815 (UMLS CUI [2,1])
C0687676 (UMLS CUI [2,2])
C0392920 (UMLS CUI [2,3])
C1265611 (UMLS CUI [2,4])
ECOG performance status
Item
ecog performance score 0-2
boolean
C1520224 (UMLS CUI [1])
Creatinine clearance measurement
Item
creatinine clearance > 60 ml/min/1.73 m2.
boolean
C0373595 (UMLS CUI [1])
SERUM TOTAL BILIRUBIN ELEVATED
Item
total bilirubin ≤2.0 x institutional upper limit of normal (iuln)
boolean
C0595866 (UMLS CUI [1])
Aspartate aminotransferase increased | Alanine aminotransferase increased | Relationship Hepatic Involvement Diffuse Large B-Cell Lymphoma
Item
ast (sgot)/alt (sgpt) ≤2.5 x iunl, or ≤5x iunl in patients with liver involvement of dlbcl
boolean
C0151904 (UMLS CUI [1])
C0151905 (UMLS CUI [2])
C0439849 (UMLS CUI [3,1])
C0441932 (UMLS CUI [3,2])
C0079744 (UMLS CUI [3,3])
Absolute neutrophil count | Hemoglobin measurement | Platelet Count measurement
Item
absolute neutrophil count >1,000 /_l; hemoglobin >9 g/ml; platelet count > 75,000 /_l at screening.
boolean
C0948762 (UMLS CUI [1])
C0518015 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
Comprehension Study Protocol | Informed Consent
Item
patients must be capable of understanding the purpose and risks of the study and able to provide written consent.
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2])
Protocol Compliance
Item
patients must be willing and able to comply with the prescribed treatment protocol and evaluations
boolean
C0525058 (UMLS CUI [1])
Experimental drug Without License
Item
treatment with experimental (unlicensed) drug within 3 weeks of treatment.
boolean
C0304229 (UMLS CUI [1,1])
C0332288 (UMLS CUI [1,2])
C0023636 (UMLS CUI [1,3])
Prior Chemotherapy | Major surgery | Therapeutic radiology procedure
Item
previous chemotherapy, or major surgery within 21 days prior to first study treatment, or radiation therapy within 6 weeks.
boolean
C1514457 (UMLS CUI [1])
C0679637 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
Rapidly progressive disorder | Organ function At risk of disease
Item
rapidly progressive disease or organ function threatened by disease
boolean
C1850776 (UMLS CUI [1])
C0678852 (UMLS CUI [2,1])
C1281905 (UMLS CUI [2,2])
Communicable Disease Serious Uncontrolled
Item
serious, uncontrolled active infections.
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
HIV Seropositivity | HEPATITIS B SEROLOGY POSITIVE | Hepatitis C virus Serology positive
Item
serologically positive for hiv, hbv, or hcv.
boolean
C0019699 (UMLS CUI [1])
C0744838 (UMLS CUI [2])
C0220847 (UMLS CUI [3,1])
C0242089 (UMLS CUI [3,2])
Cardiac dysfunction | Pulmonary Dysfunction | Liver Dysfunction
Item
clinically significant cardiac, pulmonary, and/or hepatic dysfunction
boolean
C3277906 (UMLS CUI [1])
C1709770 (UMLS CUI [2])
C0086565 (UMLS CUI [3])
Lymphoma Central Nervous System Involvement
Item
lymphoma involving the central nervous system
boolean
C0024299 (UMLS CUI [1,1])
C4050309 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
female patients who are pregnant or breast feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Comprehension Study Protocol Unable | Informed Consent Unable
Item
patients not capable of understanding the purpose and risks of the study and or unable to provide written consent.
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C0021430 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
Protocol Compliance Unwilling | Protocol Compliance Unable
Item
patients not willing and or unable to comply with the prescribed treatment protocol and evaluations
boolean
C0525058 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])