Diabetes Mellitus, Non-Insulin-Dependent
Item
patients must have a diagnosis of type 2 diabetes
boolean
C0011860 (UMLS CUI [1])
Body mass index
Item
body mass index (bmi) >=22 to <=45 kg/m2, at screening
boolean
C1305855 (UMLS CUI [1])
Metformin Dosage Stable
Item
patients must be taking a stable dosage of metformin as monotherapy at screening
boolean
C0025598 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Glucohemoglobin measurement
Item
patients must have a hba1c between >=7% and <=9.5% at week 2
boolean
C0202054 (UMLS CUI [1])
Plasma fasting glucose measurement
Item
patients must have a fasting plasma glucose (fpg) <=270 mg/dl (15 mmol/l) at week -2
boolean
C0583513 (UMLS CUI [1])
Exposure to JNJ-24831754 | Medical contraindication JNJ-24831754 | Hypersensitivity Suspected JNJ-24831754 | Exposure to Glimepiride | Medical contraindication Glimepiride | Hypersensitivity Suspected Glimepiride | Exposure to Metformin | Medical contraindication Metformin | Hypersensitivity Suspected Metformin
Item
patients having prior exposure or known contraindication or suspected hypersensitivity to jnj-28431754, glimepiride, or metformin
boolean
C0332157 (UMLS CUI [1,1])
C2987596 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C2987596 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0750491 (UMLS CUI [3,2])
C0061323 (UMLS CUI [3,3])
C0332157 (UMLS CUI [4,1])
C0061323 (UMLS CUI [4,2])
C1301624 (UMLS CUI [5,1])
C0061323 (UMLS CUI [5,2])
C0020517 (UMLS CUI [6,1])
C0750491 (UMLS CUI [6,2])
C0061323 (UMLS CUI [6,3])
C0332157 (UMLS CUI [7,1])
C0025598 (UMLS CUI [7,2])
C1301624 (UMLS CUI [8,1])
C0025598 (UMLS CUI [8,2])
C0020517 (UMLS CUI [9,1])
C0750491 (UMLS CUI [9,2])
C0025598 (UMLS CUI [9,3])
Diabetic Ketoacidosis | Diabetes Mellitus, Insulin-Dependent
Item
history of diabetic ketoacidosis or type 1 diabetes mellitus
boolean
C0011880 (UMLS CUI [1])
C0011854 (UMLS CUI [2])
Pancreas Transplantation | Pancreas beta-cell transplantation
Item
history of pancreas or beta-cell transplantation
boolean
C0030275 (UMLS CUI [1])
C0030281 (UMLS CUI [2,1])
C0040732 (UMLS CUI [2,2])
Proliferative diabetic retinopathy
Item
history of active proliferative diabetic retinopathy
boolean
C0154830 (UMLS CUI [1])
Congenital glucose-galactose malabsorption | Renal Glycosuria Primary
Item
history of hereditary glucose-galactose malabsorption or primary renal glucosuria
boolean
C0268186 (UMLS CUI [1])
C0017980 (UMLS CUI [2,1])
C0205225 (UMLS CUI [2,2])
Kidney Disease Requirement Therapeutic immunosuppression | Dialysis | Kidney Transplantation
Item
renal disease requiring treatment with immunosuppressive therapy within the past 12 months before screening or a history of dialysis or renal transplant
boolean
C0022658 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0021079 (UMLS CUI [1,3])
C0011946 (UMLS CUI [2])
C0022671 (UMLS CUI [3])
Thiazolidinediones
Item
taken thiazolidinedione therapy in the past 16 weeks before screening
boolean
C1257987 (UMLS CUI [1])