Chronic Lymphocytic Leukemia
Item
diagnosis of b-cll by nci criteria
boolean
C0023434 (UMLS CUI [1])
Chemotherapy Patient need for | Prior Chemotherapy Patient recovered
Item
require chemotherapy and have fully recovered from previous administered chemotherapy
boolean
C0392920 (UMLS CUI [1,1])
C0686904 (UMLS CUI [1,2])
C1514457 (UMLS CUI [2,1])
C1115804 (UMLS CUI [2,2])
Disease Progression | Response failed | Prior Therapy Recurrent disease | Prior Therapy intolerant | Purine analog Quantity failed
Item
subjects must have progressed, failed to achieve a meaningful response, or relapsed/intolerant to prior therapy. failing at least one purine analogue regimen
boolean
C0242656 (UMLS CUI [1])
C1704632 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
C1514463 (UMLS CUI [3,1])
C0277556 (UMLS CUI [3,2])
C1514463 (UMLS CUI [4,1])
C0231200 (UMLS CUI [4,2])
C1268902 (UMLS CUI [5,1])
C1265611 (UMLS CUI [5,2])
C0231175 (UMLS CUI [5,3])
Prior Therapy Quantity
Item
subjects have received three or fewer prior treatment regimens
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
ECOG performance status
Item
ecog status of 0 - 2
boolean
C1520224 (UMLS CUI [1])
Inclusion ceiteria Cohort Specified
Item
inclusion criteria (cohort #2):
boolean
C1512693 (UMLS CUI [1,1])
C0599755 (UMLS CUI [1,2])
C0205369 (UMLS CUI [1,3])
Dose level | Inclusion criteria Same | Prior Chemotherapy Absent | Therapy naive
Item
if dose level + 3 is reached, the criteria is the same as outlined for cohort #1, however the subjects should not have a history of prior chemotherapy (treatment naive)
boolean
C0178602 (UMLS CUI [1])
C1512693 (UMLS CUI [2,1])
C0445247 (UMLS CUI [2,2])
C1514457 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0919936 (UMLS CUI [4])
Contraceptive methods Unwilling | Contraceptive methods Unable
Item
unwilling or unable to use an acceptable method to avoid pregnancy
boolean
C0700589 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C0700589 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
Cardiovascular Disease Uncontrolled | Cardiovascular Disease | Prolonged QTc interval
Item
uncontrolled or significant cardiovascular disease, including prolonged qtc interval
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2])
C1560305 (UMLS CUI [3])
Blood Coagulation Disorder | CLL Relationship Absent
Item
history of significant bleeding disorder, unrelated to cll
boolean
C0005779 (UMLS CUI [1])
C0023434 (UMLS CUI [2,1])
C0439849 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Cancer Other
Item
prior concurrent malignancy
boolean
C1707251 (UMLS CUI [1])
Pharmaceutical Preparations At risk Torsades de Pointes
Item
drugs that generally accepted to have the risk of causing torsades de pointes
boolean
C0013227 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0040479 (UMLS CUI [1,3])
Autoimmune hemolytic anemia Treatment required for | Autoimmune hemolytic anemia Requirement Support transfusion therapy
Item
autoimmune hemolytic anemia requiring therapy or transfusion support
boolean
C0002880 (UMLS CUI [1,1])
C0332121 (UMLS CUI [1,2])
C0002880 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0436311 (UMLS CUI [2,3])
Autoimmune thrombocytopenia Requirement Steroid therapy | Autoimmune thrombocytopenia Requirement Support transfusion therapy
Item
autoimmune thrombocytopenia requiring steroid therapy or transfusion support
boolean
C0242584 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0149783 (UMLS CUI [1,3])
C0242584 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0436311 (UMLS CUI [2,3])
Richter's syndrome
Item
richter's syndrome
boolean
C0349631 (UMLS CUI [1])
Transformation Prolymphocytic Leukemia
Item
transformation to prolymphocytic leukemia
boolean
C4055129 (UMLS CUI [1,1])
C0023486 (UMLS CUI [1,2])