Chronic Lymphocytic Leukemia
Item
active cll (as defined by the national cancer institute working group)
boolean
C0023434 (UMLS CUI [1])
Prior Therapy Quantity Chronic Lymphocytic Leukemia | Nucleoside Analogs
Item
patients must have received at least one prior therapy for cll and have been treated with a nucleoside analogue.
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0023434 (UMLS CUI [1,3])
C1579410 (UMLS CUI [2])
ECOG performance status
Item
recruitment will be limited to those with an ecog performance status of 2 or less.
boolean
C1520224 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
patients who are pregnant or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Autoimmune cytopenia
Item
patients with a history of autoimmune cytopenias
boolean
C3274706 (UMLS CUI [1])
Platelet Count measurement | Absolute neutrophil count
Item
patients with platelets < 50 x 109/l or an absolute neutrophil count < 1.5x109/l
boolean
C0032181 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
Liver disease | Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
patients with hepatic disease or an ast/alt 6x above the upper limit of normal
boolean
C0023895 (UMLS CUI [1])
C0151904 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
Estimation of creatinine clearance by Cockcroft-Gault formula
Item
patients with a calculated creatinine clearance < 30 ml/min using the cockroft and gault formula
boolean
C2711451 (UMLS CUI [1])
Pancreatitis
Item
patients with a history of pancreatitis
boolean
C0030305 (UMLS CUI [1])
Pharmaceutical Preparations Affecting Valproic Acid Protein Binding | Pharmaceutical Preparations Affecting Valproic Acid Metabolism
Item
patients who are receiving drugs that affect vpa protein binding or metabolism
boolean
C0013227 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0042291 (UMLS CUI [1,3])
C0033618 (UMLS CUI [1,4])
C0013227 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0042291 (UMLS CUI [2,3])
C0025519 (UMLS CUI [2,4])
Communicable Disease | HIV Infection | Viral hepatitis
Item
patients with active infection, hiv or active viral hepatitis
boolean
C0009450 (UMLS CUI [1])
C0019693 (UMLS CUI [2])
C0042721 (UMLS CUI [3])
Secondary Malignant Neoplasm | Central Nervous System Involvement with Chronic Lymphocytic Leukemia
Item
patients with active secondary malignancy or who have central nervous system involvement with cll
boolean
C3266877 (UMLS CUI [1])
C3714787 (UMLS CUI [2,1])
C1314939 (UMLS CUI [2,2])
C0023434 (UMLS CUI [2,3])
Lymphoproliferative Disorder Aggressive | Richter's syndrome
Item
patients diagnosed with more an aggressive lymphoproliferative disorder such as richter's transformation
boolean
C0024314 (UMLS CUI [1,1])
C0580822 (UMLS CUI [1,2])
C0349631 (UMLS CUI [2])