Breast Carcinoma | Age
Item
breast cancer patients ≥18 years.
boolean
C0678222 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Indication Chemotherapy
Item
indication for 3-weekly chemotherapy.
boolean
C3146298 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
Fit Chemotherapy | Renal function | Liver function
Item
considered fit enough to receive chemotherapy, with adequate renal and hepatic function.
boolean
C0424576 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
Chemotherapy Planned Adjuvant therapy | Chemotherapy Planned Neoadjuvant Therapy | Chemotherapy Planned Advanced disease | Risk Increased Febrile Neutropenia
Item
planned a chemotherapy regime in adjuvant, neo-adjuvant, advanced setting with an increased risk of febrile neutropenia, i.e.:
boolean
C0392920 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C0677850 (UMLS CUI [1,3])
C0392920 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
C0600558 (UMLS CUI [2,3])
C0392920 (UMLS CUI [3,1])
C1301732 (UMLS CUI [3,2])
C0679246 (UMLS CUI [3,3])
C0035647 (UMLS CUI [4,1])
C0205217 (UMLS CUI [4,2])
C0746883 (UMLS CUI [4,3])
Regimen Risk Percentage Febrile Neutropenia
Item
regimes with >20% risk of febrile neutropenia:
boolean
C0392920 (UMLS CUI [1,1])
C0035647 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
C0746883 (UMLS CUI [1,4])
docetaxel | Adriamycin | Cyclophosphamide
Item
e.g. tac (docetaxel, adriamycin, cyclophosphamide)
boolean
C0246415 (UMLS CUI [1])
C0085752 (UMLS CUI [2])
C0010583 (UMLS CUI [3])
Adriamycin | docetaxel
Item
at (adriamycin, docetaxel)
boolean
C0085752 (UMLS CUI [1])
C0246415 (UMLS CUI [2])
Regimen Risk Percentage Febrile Neutropenia | Adriamycin | Cyclophosphamide | Doxorubicin | vinorelbine | docetaxel | Risk factors Quantity | Age | Bone Marrow Involvement Extensive | Therapeutic radiology procedure Extensive Bone Tissue
Item
regimes with 10-20% risk of febrile neutropenia (e.g. ac, doxorubicin and vinorelbine, or docetaxel monotherapy) in the presence of ≥1 patient risk factor (>65 yrs, extensive bone marrow involvement or prior extensive radiotherapy on bone tissue
boolean
C0392920 (UMLS CUI [1,1])
C0035647 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
C0746883 (UMLS CUI [1,4])
C0085752 (UMLS CUI [2])
C0010583 (UMLS CUI [3])
C0013089 (UMLS CUI [4])
C0078257 (UMLS CUI [5])
C0246415 (UMLS CUI [6])
C0035648 (UMLS CUI [7,1])
C1265611 (UMLS CUI [7,2])
C0001779 (UMLS CUI [8])
C1517677 (UMLS CUI [9,1])
C0205231 (UMLS CUI [9,2])
C1522449 (UMLS CUI [10,1])
C0205231 (UMLS CUI [10,2])
C0391978 (UMLS CUI [10,3])
Prior Chemotherapy
Item
prior chemotherapy
boolean
C1514457 (UMLS CUI [1])
ECOG performance status | Liver Dysfunction Grade
Item
ecog performance status of 2 or more, grade 2 or higher liver function abnormalities).
boolean
C1520224 (UMLS CUI [1])
C0086565 (UMLS CUI [2,1])
C0441800 (UMLS CUI [2,2])
docetaxel | FEC protocol | Risk Increased Febrile Neutropenia | Elderly
Item
that is, patients starting with docetaxel as second part of fec-d are eligible for the last 3 docetaxel cycles, if there is an increased risk of febrile neutropenia, e.g. by elderly age.
boolean
C0246415 (UMLS CUI [1])
C0060133 (UMLS CUI [2])
C0035647 (UMLS CUI [3,1])
C0205217 (UMLS CUI [3,2])
C0746883 (UMLS CUI [3,3])
C0001792 (UMLS CUI [4])
Protocol Compliance
Item
able to comply with the protocol.
boolean
C0525058 (UMLS CUI [1])
Informed Consent
Item
written informed consent obtained prior to any study specific screening.
boolean
C0021430 (UMLS CUI [1])
Communicable Disease Uncontrolled
Item
active uncontrolled infection.
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Abnormal renal function | Liver Dysfunction
Item
inadequate renal or hepatic function.
boolean
C0151746 (UMLS CUI [1])
C0086565 (UMLS CUI [2])
Hypersensitivity G-CSF Pharmaceutical Preparations | Medical contraindication G-CSF Pharmaceutical Preparations
Item
any evidence or history of hypersensitivity or other contraindications to g-csf medication.
boolean
C0020517 (UMLS CUI [1,1])
C0079459 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
C1301624 (UMLS CUI [2,1])
C0079459 (UMLS CUI [2,2])
C0013227 (UMLS CUI [2,3])
Therapy-Related Toxicity | Recovery Lacking
Item
not recovered from acute toxicities of prior therapies.
boolean
C1710382 (UMLS CUI [1])
C2004454 (UMLS CUI [2,1])
C0332268 (UMLS CUI [2,2])
Absolute neutrophil count | Etiology Bone Marrow Involvement Absent
Item
absolute neutrophil count (anc) <1.5 x 109/l, not caused by bone marrow involvement.
boolean
C0948762 (UMLS CUI [1])
C0015127 (UMLS CUI [2,1])
C1517677 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])