Dementia due to Parkinson's disease
Item
clinical diagnosis of dementia due to parkinson's disease (according to the fourth edition of the diagnostic and statistical manual of mental disorders (code 294.1)
boolean
C0236960 (UMLS CUI [1])
Mini-mental state examination | Cognitive symptoms
Item
mmse score between 18 and 26, inclusive; cognitive symptoms must occur at least one year after the diagnosis of pdd
boolean
C0451306 (UMLS CUI [1])
C0525041 (UMLS CUI [2])
Apnea-hypopnea index
Item
apnea hypopnea index >10 (i.e., 10 apneas plus hypopneas per hour of sleep)
boolean
C2111846 (UMLS CUI [1])
Age
Item
over the age of 50 years
boolean
C0001779 (UMLS CUI [1])
Health Stable
Item
stable health
boolean
C0018684 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Able to speak fluently English Language
Item
fluent english speaking
boolean
C0564241 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
Dopaminergic Agents | Acetylcholinesterase Inhibitors | Psychotropic Drugs | Nootropic Agents | Dietary Supplements | Pharmaceutical Preparations Dose Stable
Item
patients will be allowed to continue dopaminergic medications, acetylcholinesterase inhibitors, psychotropic medications, memory enhancers, health food supplements, etc. as long as they have been stable on the same dose for at least two months prior to participation and agree to continue on this dose for the duration of the 6-week study.
boolean
C0013036 (UMLS CUI [1])
C0001046 (UMLS CUI [2])
C0033978 (UMLS CUI [3])
C0242913 (UMLS CUI [4])
C0242295 (UMLS CUI [5])
C0013227 (UMLS CUI [6,1])
C0178602 (UMLS CUI [6,2])
C0205360 (UMLS CUI [6,3])
Therapeutic procedure Sleep Apnea
Item
current treatment for sleep apnea (to avoid discontinuing already established treatment for sleep apnea and any carry over confounding effect of treatment on cognition).
boolean
C0087111 (UMLS CUI [1,1])
C0037315 (UMLS CUI [1,2])
Sleep Apnea, Central
Item
central sleep apnea
boolean
C0520680 (UMLS CUI [1])
Pharmaceutical Preparations Affecting Sleep | Sedative hypnotics | Narcotics
Item
use of medications known to influence sleep (i.e. sedative hypnotics, narcotics) if the dose cannot remain stable for the duration of the study.
boolean
C0013227 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0037313 (UMLS CUI [1,3])
C0020592 (UMLS CUI [2])
C0027415 (UMLS CUI [3])
Chronic Obstructive Airway Disease Bronchial Spasm | Chronic Obstructive Airway Disease Symptomatic | Bronchodilator Agents Regular | Steroids | Hypercapnia | Hypoxemia Waking | PaO2 Pulse Oximetry | SpO2 Pulse Oximetry | Receiving supplemental oxygen
Item
bronchospastic and symptomatic chronic obstructive pulmonary disease as indicated by regular use of bronchodilators, steroids, history of carbon dioxide retention, waking hypoxemia (pao2 <60 mmhg or spo2 <92 % by pulse oximetry), or use of supplemental oxygen.
boolean
C0024117 (UMLS CUI [1,1])
C0006266 (UMLS CUI [1,2])
C0024117 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0006280 (UMLS CUI [3,1])
C0205272 (UMLS CUI [3,2])
C0038317 (UMLS CUI [4])
C0020440 (UMLS CUI [5])
C0700292 (UMLS CUI [6,1])
C0442696 (UMLS CUI [6,2])
C1822073 (UMLS CUI [7,1])
C0034108 (UMLS CUI [7,2])
C2317096 (UMLS CUI [8,1])
C0034108 (UMLS CUI [8,2])
C3841316 (UMLS CUI [9])
Cardiovascular Diseases Symptomatic | Cerebrovascular Disorders Symptomatic | Myocardial Infarction | Angina Pectoris | Cerebrovascular accident | Transient Ischemic Attack | Cardiac Arrhythmia Life Threatening | Cardiomyopathy | Substance Use Disorders
Item
symptomatic coronary or cerebral vascular disease (history of myocardial infarction, angina, stroke, or transient ischemic attacks), history of life-threatening arrhythmias, cardiomyopathy, or current alcohol or drug abuse
boolean
C0007222 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0007820 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0027051 (UMLS CUI [3])
C0002962 (UMLS CUI [4])
C0038454 (UMLS CUI [5])
C0007787 (UMLS CUI [6])
C0003811 (UMLS CUI [7,1])
C2826244 (UMLS CUI [7,2])
C0878544 (UMLS CUI [8])
C0038586 (UMLS CUI [9])
Epilepsy | Neurodegenerative Disorders | Exception Dementia due to Parkinson's disease | Exception Causes Dementia
Item
current diagnosis of active seizure disorder; presence of any neurodegenerative disorder other than pdd or other causes of dementia
boolean
C0014544 (UMLS CUI [1])
C0524851 (UMLS CUI [2])
C1705847 (UMLS CUI [3,1])
C0236960 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0015127 (UMLS CUI [4,2])
C0497327 (UMLS CUI [4,3])
Behavioral problem Excludes Evaluation | Physical illness Excludes Evaluation | Behavioral problem Excludes CPAP | Physical illness Excludes CPAP
Item
any behavioral or physical problem that would preclude completion of the primary evaluation or treatment with cpap.
boolean
C0233514 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C1261322 (UMLS CUI [1,3])
C0683323 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C1261322 (UMLS CUI [2,3])
C0233514 (UMLS CUI [3,1])
C0332196 (UMLS CUI [3,2])
C0199451 (UMLS CUI [3,3])
C0683323 (UMLS CUI [4,1])
C0332196 (UMLS CUI [4,2])
C0199451 (UMLS CUI [4,3])