Large B-Cell Lymphoma
Item
histologically confirmed large b-cell lymphoma
boolean
C0079744 (UMLS CUI [1])
Disease Ann Arbor lymphoma staging system
Item
stage i, ii, iii, or iv disease
boolean
C0012634 (UMLS CUI [1,1])
C0432516 (UMLS CUI [1,2])
Bone Marrow Involvement Small Cell Lymphoma | Lymph Node Involvement Small Cell Lymphoma
Item
bone marrow or lymph node involvement by small cell lymphoma allowed
boolean
C1517677 (UMLS CUI [1,1])
C0024303 (UMLS CUI [1,2])
C0806692 (UMLS CUI [2,1])
C0024303 (UMLS CUI [2,2])
Pathology Serious Progressive Absent
Item
no serious, progressive pathology (at investigator's discretion)
boolean
C0677042 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205329 (UMLS CUI [1,3])
C0332197 (UMLS CUI [1,4])
Disease CD20 antigen positive
Item
cd20-positive disease
boolean
C0012634 (UMLS CUI [1,1])
C3888518 (UMLS CUI [1,2])
Measurable Disease
Item
measurable disease
boolean
C1513041 (UMLS CUI [1])
Indolent lymphoma Treated Absent | Indolent lymphoma Untreated Absent
Item
no prior indolent lymphoma, treated or not
boolean
C1334170 (UMLS CUI [1,1])
C1522326 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C1334170 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Meningeal Lymphoma Absent | Central nervous system lymphoma Absent
Item
no meningeal or cns lymphoma
boolean
C2213017 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0742472 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Client Characteristics
Item
patient characteristics:
boolean
C0815172 (UMLS CUI [1])
International Prognostic Index Age adjusted
Item
international prognostic index < 2 (adjusted for age)
boolean
C1512894 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0456081 (UMLS CUI [1,3])
Life Expectancy
Item
life expectancy > 3 months
boolean
C0023671 (UMLS CUI [1])
Alanine aminotransferase measurement | Aspartate aminotransferase measurement
Item
alt and ast ≤ 2.5 times upper limit of normal
boolean
C0201836 (UMLS CUI [1])
C0201899 (UMLS CUI [2])
Serum total bilirubin measurement
Item
bilirubin ≤ 30 mmol/l
boolean
C1278039 (UMLS CUI [1])
Creatinine measurement, serum
Item
creatinine ≤ 150 μmol/l
boolean
C0201976 (UMLS CUI [1])
HIV negative | Hepatitis B test negative | Hepatitis C test negative | Status post Vaccine Excluded
Item
hiv, hepatitis b virus, and hepatitis c virus negative (unless after vaccine)
boolean
C0481430 (UMLS CUI [1])
C1611173 (UMLS CUI [2])
C1619717 (UMLS CUI [3])
C0231290 (UMLS CUI [4,1])
C0042210 (UMLS CUI [4,2])
C2828389 (UMLS CUI [4,3])
Exclusion Criteria | Medical contraindication Chemotherapy | Medical contraindication Immunotherapy
Item
no contraindication to chemotherapy or immunotherapy
boolean
C0680251 (UMLS CUI [1])
C1301624 (UMLS CUI [2,1])
C0392920 (UMLS CUI [2,2])
C1301624 (UMLS CUI [3,1])
C0021083 (UMLS CUI [3,2])
Malignant Neoplasms Exclusion | Basal cell carcinoma | Carcinoma in situ of uterine cervix
Item
no cancer in the past 5 years except basal cell skin cancer or carcinoma in situ of the cervix
boolean
C0006826 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
C0007117 (UMLS CUI [2])
C0851140 (UMLS CUI [3])
Exclusion Criteria | Medical contraindication Intravenous Catheters
Item
no contraindication to a venous catheter
boolean
C0680251 (UMLS CUI [1])
C1301624 (UMLS CUI [2,1])
C0745442 (UMLS CUI [2,2])
Therapeutic procedure
Item
prior concurrent therapy:
boolean
C0087111 (UMLS CUI [1])
ID.20
Item
see disease characteristics
boolean
Investigational Therapy Excluded
Item
at least 30 days since prior and no other concurrent investigational treatment
boolean
C0949266 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
Prior Therapy Excluded
Item
no prior therapy
boolean
C1514463 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
Exclusion Participation Clinical Trial Other
Item
no concurrent participation in another clinical study
boolean
C2828389 (UMLS CUI [1,1])
C0679823 (UMLS CUI [1,2])
C0008976 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,4])