Colorectal Carcinoma
Item
histologically confirmed colorectal cancer
boolean
C0009402 (UMLS CUI [1])
Oxaliplatin Patient need for | FOLFOX Regimen
Item
requires treatment with oxaliplatin (as part of a folfox regimen)
boolean
C0069717 (UMLS CUI [1,1])
C0686904 (UMLS CUI [1,2])
C0392943 (UMLS CUI [2])
Metastatic malignant neoplasm to brain Absent | Meningitis Symptomatic Absent
Item
no brain metastases or symptomatic meningitis
boolean
C0220650 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0025289 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Client Characteristics
Item
patient characteristics:
boolean
C0815172 (UMLS CUI [1])
WHO performance status scale
Item
who performance status 0-2
boolean
C1298650 (UMLS CUI [1])
Life Expectancy
Item
life expectancy > 3 months
boolean
C0023671 (UMLS CUI [1])
Absolute neutrophil count
Item
anc ≥ 1 x 10^9/l
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
platelet count ≥ 100 x 10^9/l
boolean
C0032181 (UMLS CUI [1])
Elevated total bilirubin
Item
total bilirubin ≤ 2 times upper limit of normal (uln)
boolean
C0741494 (UMLS CUI [1])
Serum transaminase increased
Item
transaminases ≤ 3 times uln
boolean
C0859350 (UMLS CUI [1])
Alkaline phosphatase raised
Item
alkaline phosphatase ≤ 5 times uln
boolean
C0151849 (UMLS CUI [1])
Pregnancy Absent | Breast Feeding Absent
Item
not pregnant or nursing
boolean
C0032961 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0006147 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Fertility Contraceptive methods
Item
fertile patients must use effective contraception
boolean
C0015895 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Neuropathy Clinical Absent
Item
no prior or concurrent clinical neuropathy (regardless of the etiology)
boolean
C0442874 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
Dihydropyrimidine Dehydrogenase Deficiency Absent
Item
no dihydropyrimidine dehydrogenase deficiency
boolean
C1959620 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Exclusion Criteria | Mental disorders Preventing Comprehension Study Protocol | Mental disorders Informed Consent Unable
Item
no psychiatric illness that would preclude comprehension of the study or of the informed consent
boolean
C0680251 (UMLS CUI [1])
C0004936 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0162340 (UMLS CUI [2,3])
C2348563 (UMLS CUI [2,4])
C0004936 (UMLS CUI [3,1])
C0021430 (UMLS CUI [3,2])
C1299582 (UMLS CUI [3,3])
Exclusion Criteria | Illness Severe Worsening | Heart Diseases Unstable | Myocardial Infarction | Communicable Diseases Uncontrolled
Item
no other severe illness that may worsen during treatment, including unstable cardiac disease, myocardial infarction within the past 6 months, or active uncontrolled infection
boolean
C0680251 (UMLS CUI [1])
C0221423 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0332271 (UMLS CUI [2,3])
C0018799 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0027051 (UMLS CUI [4])
C0009450 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
Exclusion Criteria | Psychological Factors Preventing Clinical Study Follow-up | Social situation Preventing Clinical Study Follow-up | Problem Familial Preventing Clinical Study Follow-up | Geographical environment Preventing Clinical Study Follow-up
Item
no psychological, social, familial, or geographical reason that would preclude study follow-up
boolean
C0680251 (UMLS CUI [1])
C0033898 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C3274571 (UMLS CUI [2,3])
C0748872 (UMLS CUI [3,1])
C1292733 (UMLS CUI [3,2])
C3274571 (UMLS CUI [3,3])
C0033213 (UMLS CUI [4,1])
C0241888 (UMLS CUI [4,2])
C1292733 (UMLS CUI [4,3])
C3274571 (UMLS CUI [4,4])
C0565935 (UMLS CUI [5,1])
C1292733 (UMLS CUI [5,2])
C3274571 (UMLS CUI [5,3])
Malignant Neoplasms | Therapeutic procedure Without Platinum derivatives | Therapeutic procedure Without Taxanes
Item
other cancer within the past 5 years allowed provided treatment did not include platinum derivatives or taxanes
boolean
C0006826 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C0332288 (UMLS CUI [2,2])
C0032207 (UMLS CUI [2,3])
C0243072 (UMLS CUI [2,4])
C0087111 (UMLS CUI [3,1])
C0332288 (UMLS CUI [3,2])
C0796419 (UMLS CUI [3,3])
Prior Therapy
Item
prior concurrent therapy:
boolean
C1514463 (UMLS CUI [1])
ID.21
Item
see disease characteristics
boolean
Prior Chemotherapy | Platinum derivatives | Taxanes
Item
prior chemotherapy allowed (except for platinum derivatives or taxanes)
boolean
C1514457 (UMLS CUI [1])
C0032207 (UMLS CUI [2,1])
C0243072 (UMLS CUI [2,2])
C0796419 (UMLS CUI [3])