metastatic adenocarcinoma of the colon or rectum
Item
patients with histologically proven metastatic adenocarcinoma of the colon or rectum
boolean
C0338106 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0149978 (UMLS CUI [2,1])
C0027627 (UMLS CUI [2,2])
fu-based chemotherapy and free of disease for at least 6 months
Item
previous chemotherapy for metastatic disease not allowed. patients who received prior adjuvant 5-fu-based chemotherapy are eligible if they have remained free of disease for at least 6 months after the completion of adjuvant therapy
boolean
C0016360 (UMLS CUI [1,1])
C2919733 (UMLS CUI [1,2])
operable metastatic disease
Item
patients with operable metastatic disease are excluded from the study
boolean
C0027627 (UMLS CUI [1,1])
C0205188 (UMLS CUI [1,2])
age
Item
age 18-70 years
boolean
C0001779 (UMLS CUI [1])
eco performance status
Item
performance status (ecog) 0-1
boolean
C1520224 (UMLS CUI [1])
bidimensionally measurable lesion
Item
at least one bidimensionally measurable lesion of >= 2cm
boolean
C0221198 (UMLS CUI [1])
life expectancy
Item
life expectancy of at least 6 months
boolean
C0023671 (UMLS CUI [1])
Absolute neutrophil count Blood Platelets
Item
adequate hematologic parameters (absolute neutrophil count >= 1.5x109/l and platelets >=100x109/l)
boolean
C0948762 (UMLS CUI [1])
C0005821 (UMLS CUI [2])
creatinine and total bilirubin
Item
creatinine and total bilirubin < 1.25 times the upper limit of normal
boolean
C0201976 (UMLS CUI [1])
C0201913 (UMLS CUI [2])
aspartate and alanine aminotransferase
Item
aspartate and alanine aminotransferase < 3.0 times the upper limit of normal (<5 times in case of liver mets)
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
active infection or malnutrition
Item
absence of active infection or malnutrition (loss of more than 20% of the body weight)
boolean
C0009450 (UMLS CUI [1])
C0162429 (UMLS CUI [2])
no history of a second primary tumor other than non-melanoma skin cancer or in situ cervical carcinoma. curatively treated
Item
no history of a second primary tumor other than non-melanoma skin cancer or in situ cervical carcinoma. curatively treated
boolean
C0085183 (UMLS CUI [1,1])
C0007114 (UMLS CUI [1,2])
C0184780 (UMLS CUI [1,3])
C0851140 (UMLS CUI [2,1])
C0184780 (UMLS CUI [2,2])
palliative radiotherapy
Item
patients treated with palliative radiotherapy had to have measurable metastatic disease outside the irradiation fields.
boolean
C3898008 (UMLS CUI [1])
cardiac dysfunction, liver metastases involving more than 50%, chronic diarrhea, or irradiation of 30% of bone marrow
Item
patients with severe cardiac dysfunction, liver metastases involving more than 50% of the liver parenchyma, chronic diarrhea, or prior irradiation affecting more than 30% of the active bone marrow are excluded.
boolean
C3277906 (UMLS CUI [1])
C3494607 (UMLS CUI [2])
C0401151 (UMLS CUI [3])
C0436251 (UMLS CUI [4])
informed consent
Item
all patients will have to sign written informed consent in order to participate in the study
boolean
C0021430 (UMLS CUI [1])