Esophageal carcinoma
Item
Histologically verified adenocarcinoma of the esophagus according to the UICC definition (TNM7)
boolean
C0152018 (UMLS CUI [1])
Pre-Treatment Stage
Item
Pre-treatment stage cT1N+, M0 or cT2-4a, N0/+, M0
boolean
C0178759 (UMLS CUI [1,1])
C2709094 (UMLS CUI [1,2])
Age
Item
Age ≥18 years
boolean
C0001779 (UMLS CUI [1])
Prior Radiotherapy
Item
No prior abdominal or thoracic radiotherapy
boolean
C0279134 (UMLS CUI [1])
ECOG Performance Status
Item
ECOG Performance status 0-2
boolean
C1520224 (UMLS CUI [1])
Cardiac function
Item
Adequate cardiac function ( Patients with a cardiac history (e.g. myocardial infarction, heart failure, coronary artery disease) should have a cardiology review)
boolean
C0232164 (UMLS CUI [1])
Bone Marrow Function
Item
Adequate bone marrow function (WBC>3x10^9/l; Hb>9g/dl; platelets >100x10^9/l)
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
Pulmonary Function
Item
Adequate respiratory function. Symptomatic Patients should have pulmonary function tests with FEV1>1,5l )
boolean
C0231921 (UMLS CUI [1])
Renal Function
Item
Adequate renal function (GFR >60ml/min)
boolean
C0232804 (UMLS CUI [1])
Liver Function
Item
Adequate liver function (serum bilirubin <1.5x Upper level of Normal (ULN); AST <2.5x ULN and ALT <3x ULN (ULN as per institutional standard)
boolean
C0232741 (UMLS CUI [1])
Informed Consent
Item
Written informed consent
boolean
C0021430 (UMLS CUI [1])
Histological finding
Item
Tumors of squamous or other non-adenocarcinoma histology
boolean
C0449575 (UMLS CUI [1])
Inoperable Tumor, Metastatic Disease
Item
Patients with advanced inoperable or metastatic esophageal adenocarcinoma
boolean
C0205187 (UMLS CUI [1])
C0027627 (UMLS CUI [2])
Tumor Stage
Item
Stage cT1N0 and cT4b
boolean
C1300072 (UMLS CUI [1])
Stomach Carcinoma
Item
Gastric carcinoma
boolean
C0699791 (UMLS CUI [1])
Prior chemotherapy
Item
Prior chemotherapy for cancer,
boolean
C1514457 (UMLS CUI [1])
Cardiac Disease
Item
Clinically significant (i.e. active) cardiac disease (e.g. symptomatic coronary artery disease or myocardial infarction within last 12 months)
boolean
C0018799 (UMLS CUI [1])
Lung Disease
Item
Clinical significant lung disease (FEV 1<1,5l)
boolean
C0024115 (UMLS CUI [1])
Neuropathy Grade
Item
Peripheral neuropathy Grade >1
boolean
C0442874 (UMLS CUI [1,1])
C0441800 (UMLS CUI [1,2])
Control Group
Item
Healthy Volunteers
boolean
C0009932 (UMLS CUI [1])