Age
Item
Ages Eligible for Study: 18 Years and older (Adult, Senior)
boolean
C0001779 (UMLS CUI [1])
Huntington's Disease
Item
Clinically symptomatic and genetically confirmed HD (number of CAG repeats ≥ 36)
boolean
C0020179 (UMLS CUI [1])
Huntington Disease Status
Item
Moderate stage of the disease (UHDRS motor score ≥ 30)
boolean
C0020179 (UMLS CUI [1,1])
C0699749 (UMLS CUI [1,2])
Huntington Disease Treatment
Item
Chorea despite best medical treatment (UHDRS chorea subscore ≥ 10)
boolean
C0020179 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
Dementia Score
Item
Mattis Dementia Rating Scale ≥ 120 (or > 80% of items testable independently from motor impairment)
boolean
C0497327 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
Stable Status
Item
Patient has stable medication prior six weeks before inclusion
boolean
C0205360 (UMLS CUI [1])
Informed Consent
Item
Signed informed consent
boolean
C0021430 (UMLS CUI [1])
Control Group
Item
Healthy Volunteers
boolean
C0009932 (UMLS CUI [1])
Juvenile Huntington Disease or predominant bradykinesia
Item
Juvenile HD (Westphal variant) or predominant bradykinesia
boolean
C0751208 (UMLS CUI [1])
C0233565 (UMLS CUI [2])
Postural instability
Item
Postural instability with UHDRS retropulsion score > 2
boolean
C1843921 (UMLS CUI [1])
Comorbidity
Item
Severe comorbidity compromising operability and/or life expectancy and/or quality of life during the trial duration (e.g. cancer with life expectancy < 6 months, NYHA 3 and 4 rising the anaesthetic risk according to the anaesthesiologist)
boolean
C0009488 (UMLS CUI [1])
Suicidality
Item
Acute suicidality
boolean
C0438696 (UMLS CUI [1])
Acute psychosis
Item
Acute psychosis (symptoms within previous 6 months)
boolean
C0281774 (UMLS CUI [1])
Study Participation Status
Item
Participation in any interventional clinical trial within 2 months before screening
boolean
C2348568 (UMLS CUI [1])
Cerebral atrophy
Item
Cortical atrophy grade 3
boolean
C0235946 (UMLS CUI [1])
Bleeding disorder
Item
Patients with risk of coagulopathies and/or increased risk of haemorrhage
boolean
C0005779 (UMLS CUI [1])
Pacemaker or defibrillator
Item
Patients with an implanted pacemaker or defibrillator
boolean
C0030163 (UMLS CUI [1])
C0180307 (UMLS CUI [2])
Pregnancy
Item
Pregnancy
boolean
C0032961 (UMLS CUI [1])
Lactation
Item
Lactation
boolean
C0006147 (UMLS CUI [1])