Deep brain stimulator implant
Item
a) patients must have had the deep brain stimulator implanted for at least six months prior to enrollment.
boolean
C4069029 (UMLS CUI [1])
Hoehn and Yahr Stage | Stimulation Off | Pharmaceutical Preparations Off
Item
hoehn and yahr stage iii or worse when off stimulation and medication
boolean
C3639483 (UMLS CUI [1])
C1292856 (UMLS CUI [2,1])
C1518543 (UMLS CUI [2,2])
C0013227 (UMLS CUI [3,1])
C1518543 (UMLS CUI [3,2])
Motor fluctuations Disabling Intractable | Dyskinetic syndrome | Freezing Episode of
Item
intractable, disabling motor fluctuations, dyskinesias or freezing episodes
boolean
C1868976 (UMLS CUI [1,1])
C4061999 (UMLS CUI [1,2])
C0205269 (UMLS CUI [1,3])
C0013384 (UMLS CUI [2])
C3639445 (UMLS CUI [3,1])
C0332189 (UMLS CUI [3,2])
Age
Item
age between 30-75 years
boolean
C0001779 (UMLS CUI [1])
Normal Cognition
Item
normal cognition
boolean
C2712133 (UMLS CUI [1])
Levodopa | Good therapeutic response | Atypical Parkinson Disease | Progressive supranuclear palsy | Multiple System Atrophy | Striatonigral Degeneration | Neurologic Examination UPDRS - Motor Examination Sub-total
Item
demonstrated good response to levodopa. in order to exclude patients with parkinson's plus (i.e. progressive supranuclear palsy, multiple system atrophy, striato-nigral degeneration, etc) all patients included in this study must have demonstrated a good response to levodopa, defined as demonstrating at least 30% improvement in parkinsonian motor signs, based on updrs motor examination subscore following the administration of levodopa during their screening neurological exam.
boolean
C0023570 (UMLS CUI [1])
C0184785 (UMLS CUI [2])
C1868596 (UMLS CUI [3])
C0038868 (UMLS CUI [4])
C0393571 (UMLS CUI [5])
C0270733 (UMLS CUI [6])
C0027853 (UMLS CUI [7,1])
C3827704 (UMLS CUI [7,2])
Antiparkinson Agents Stable Optimal | Clinical Response Unsatisfactory
Item
unsatisfactory clinical response to maximal medical management a stable and optimal medical regimen of antiparkinsonian drug therapy for at least three months prior to or after surgery
boolean
C0003405 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C2698651 (UMLS CUI [1,3])
C4055223 (UMLS CUI [2,1])
C0439856 (UMLS CUI [2,2])
Disease Risk Increased Postoperative Complications | Disease Risk Complication Preoperative | Heart Diseases | Lung diseases | Uncontrolled hypertension
Item
clinically significant medical disease that would increase risk of developing pre- or postoperative complications (e.g. significant cardiac or pulmonary disease, uncontrolled hypertension).
boolean
C0012634 (UMLS CUI [1,1])
C0035647 (UMLS CUI [1,2])
C0442805 (UMLS CUI [1,3])
C0032787 (UMLS CUI [1,4])
C0012634 (UMLS CUI [2,1])
C0035647 (UMLS CUI [2,2])
C0009566 (UMLS CUI [2,3])
C0445204 (UMLS CUI [2,4])
C0018799 (UMLS CUI [3])
C0024115 (UMLS CUI [4])
C1868885 (UMLS CUI [5])
Secondary Parkinson Disease Evidence of | Atypical Parkinson Disease Evidence of
Item
evidence of secondary or atypical parkinsonism as suggested by:
boolean
C0030569 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C1868596 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])
Cerebrovascular accident | Toxin Exposure to | Antipsychotic Agents | Encephalitis
Item
history of cva's, exposure to toxins, neuroleptics or encephalitis
boolean
C0038454 (UMLS CUI [1])
C0040549 (UMLS CUI [2,1])
C0332157 (UMLS CUI [2,2])
C0040615 (UMLS CUI [3])
C0014038 (UMLS CUI [4])
Neurologic Signs Involvement Upper motor neuron | Neurologic Signs Involvement Cerebellum | Supranuclear gaze palsy | Orthostatic hypertension
Item
neurologic signs of upper motor neuron or cerebellar involvement, supranuclear gaze palsy or significant orthostatic hypertension
boolean
C0751378 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C0524458 (UMLS CUI [1,3])
C0751378 (UMLS CUI [2,1])
C1314939 (UMLS CUI [2,2])
C0007765 (UMLS CUI [2,3])
C1720037 (UMLS CUI [3])
C0544618 (UMLS CUI [4])
Dementia Evidence of | Neuropsychologic impairment Quantity | Neuropsychologic impairment Additional | Borderline Neuropsychologic impairment Additional
Item
dementia as evidenced by impairment in two neuropsychological domains and impaired or borderline neuropsychological function in one additional domain
boolean
C0497327 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C1854569 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1854569 (UMLS CUI [3,1])
C1524062 (UMLS CUI [3,2])
C0870217 (UMLS CUI [4,1])
C1854569 (UMLS CUI [4,2])
C1524062 (UMLS CUI [4,3])
Deep Brain Stimulation Mental disorders | Obsessive-Compulsive Disorder | Depressive disorder
Item
use of dbs for psychiatric disorder (obsessive compulsive or depression)
boolean
C0394162 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])
C0028768 (UMLS CUI [2])
C0011581 (UMLS CUI [3])