Age
Item
age 30-55 years
boolean
C0001779 (UMLS CUI [1])
Gender
Item
gender: men and women
boolean
C0079399 (UMLS CUI [1])
Ethnic group All
Item
ethnicity: all ethnic groups
boolean
C0015031 (UMLS CUI [1,1])
C0444868 (UMLS CUI [1,2])
Study Subject Quantity | Diabetes Mellitus | Pioglitazone Absent | Pioglitazone Initiation
Item
140 subjects with diabetes and no pioglitazone (recently started i.e. less than 3 months as well as those who have just initiated pioglitazone treatment)
boolean
C0681850 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0011849 (UMLS CUI [2])
C0071097 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0071097 (UMLS CUI [4,1])
C1704686 (UMLS CUI [4,2])
Control Group Study Subject Quantity | Diabetes Mellitus | Pioglitazone Absent
Item
140 control subjects (subjects with diabetes and not on pioglitazone) will be included
boolean
C0009932 (UMLS CUI [1,1])
C0681850 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0011849 (UMLS CUI [2])
C0071097 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Control Group Study Subject | Match Age | Match Gender | Match Ethnic group | Tobacco use Similarity | Alcohol consumption Similarity
Item
the control subjects will be chosen to match age, sex, ethnicity and comparable smoking and alcohol history
boolean
C0009932 (UMLS CUI [1,1])
C0681850 (UMLS CUI [1,2])
C1708943 (UMLS CUI [2,1])
C0001779 (UMLS CUI [2,2])
C1708943 (UMLS CUI [3,1])
C0079399 (UMLS CUI [3,2])
C1708943 (UMLS CUI [4,1])
C0015031 (UMLS CUI [4,2])
C0543414 (UMLS CUI [5,1])
C2348205 (UMLS CUI [5,2])
C0001948 (UMLS CUI [6,1])
C2348205 (UMLS CUI [6,2])
Vitamin D Administration | Calcium supplement Administration
Item
to avoid confusion factor of vitamin d and calcium intake, all the subjects will be given vitamin d and calcium supplements (usda recommended doses)
boolean
C0042866 (UMLS CUI [1,1])
C1533734 (UMLS CUI [1,2])
C3661604 (UMLS CUI [2,1])
C1533734 (UMLS CUI [2,2])
Informed Consent Unable | Informed Consent Unwilling
Item
patients who are unable or unwilling yo give informed consent
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
Immobilization | Bedridden
Item
immobilized or bed bound subject
boolean
C0020944 (UMLS CUI [1])
C0741453 (UMLS CUI [2])
Disease Associated with Metabolic Bone Disorder | Chronic Kidney Insufficiency | Steroid use chronic | Hyperparathyroidism, Primary | Hyperthyroidism untreated | Paget's Disease | Decreased glomerular filtration rate | Creatinine normal | Glomerular Filtration Rate
Item
subjects wil known diseases associated with disordered bone metabolism such as chronic renal insufficiency, chronic steroid use, primary hyperparathyroidism, untreated subclinical or clinical hyperthyroidism and paget's disease. to identify subjects with decreased glomerular filtration rate (gfr) even if creatinine is normal will be excluded (at the proposed study site, routine bm includes calculated gfr from the chemistry lab)
boolean
C0012634 (UMLS CUI [1,1])
C0332281 (UMLS CUI [1,2])
C0005944 (UMLS CUI [1,3])
C0403447 (UMLS CUI [2])
C0281991 (UMLS CUI [3,1])
C0205191 (UMLS CUI [3,2])
C0221002 (UMLS CUI [4])
C0020550 (UMLS CUI [5,1])
C0332155 (UMLS CUI [5,2])
C1368019 (UMLS CUI [6])
C0853068 (UMLS CUI [7])
C0860945 (UMLS CUI [8])
C0017654 (UMLS CUI [9])
Pharmaceutical Preparations Changing Bone metabolism | Glucocorticoids | Gonadal Hormones | Testosterone | Estrogens
Item
patients on medications that will alter bone metabolism will be excluded. they are glucocorticoids, gonadal hormones (testosterone in men and estrogen in women).
boolean
C0013227 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
C0596204 (UMLS CUI [1,3])
C0017710 (UMLS CUI [2])
C0301819 (UMLS CUI [3])
C0039601 (UMLS CUI [4])
C0014939 (UMLS CUI [5])
Pancreatitis, Chronic | Pancreatectomy | Malabsorption Syndrome | Factor Affecting Vitamin D metabolic process | Factor Affecting Bone mineral metabolism
Item
subjects with known history of chronic pancreatitis, pancreatectomy or malabsorption syndromes to avoid confounding factors known to affect vitamin d metabolism and indirectly bone mineral metabolism.
boolean
C0149521 (UMLS CUI [1])
C0030279 (UMLS CUI [2])
C0024523 (UMLS CUI [3])
C1521761 (UMLS CUI [4,1])
C0392760 (UMLS CUI [4,2])
C1159433 (UMLS CUI [4,3])
C1521761 (UMLS CUI [5,1])
C0392760 (UMLS CUI [5,2])
C0262950 (UMLS CUI [5,3])
C0678715 (UMLS CUI [5,4])
Perimenopause | Menopause | Hypogonadism | Ovariectomy | Postmenopausal state | Bone remodeling Change Secondary to Hypogonadism | Perimenopausal state Follicle stimulating hormone measurement | Perimenopausal state Luteinizing hormone measurement | FSH increased | Gender Age Gonadal Hormones Evaluation
Item
female patients with perimenopause or menopause: history of hypogonadism (history of ovariectomy or postmenopausal women) to avoid bone turn over changes secondary to hypogonadism. perimenopausal women identifies by screening fsh and lh and excluding women with elevated fsh be excluded to avoid perimenopausal effect on bone turnover (women over 35 will still have a screening gonadal hormonal evaluation).
boolean
C0993589 (UMLS CUI [1])
C0025320 (UMLS CUI [2])
C0020619 (UMLS CUI [3])
C0029936 (UMLS CUI [4])
C0232970 (UMLS CUI [5])
C0085268 (UMLS CUI [6,1])
C0392747 (UMLS CUI [6,2])
C0175668 (UMLS CUI [6,3])
C0020619 (UMLS CUI [6,4])
C3839366 (UMLS CUI [7,1])
C0202022 (UMLS CUI [7,2])
C3839366 (UMLS CUI [8,1])
C0202123 (UMLS CUI [8,2])
C0151679 (UMLS CUI [9])
C0079399 (UMLS CUI [10,1])
C0001779 (UMLS CUI [10,2])
C0301819 (UMLS CUI [10,3])
C1261322 (UMLS CUI [10,4])