Non-Small Cell Lung Carcinoma Advanced | Non-small cell lung cancer metastatic | Prior Chemotherapy Absent
Item
must have advanced or metastatic non-small cell lung cancer that has not been previously treated with any chemotherapy.
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C0278987 (UMLS CUI [2])
C1514457 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Cetuximab Absent | Iressa Absent | Tarceva Absent
Item
must not have received cetuximab or any medications that target the same pathway as cetuximab (such as iressa or tarceva).
boolean
C0995188 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0919281 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1135136 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Monoclonal Antibodies Hypersensitivity Absent | Monoclonal Antibodies Allergic Reaction Severe Absent | Restrictive lung disease Severe Absent | Interstitial Lung Diseases Severe Absent
Item
must not have had hypersensitivity or severe allergic reactions to any monoclonal antibodies and must not have severe restrictive or interstitial lung disease.
boolean
C0003250 (UMLS CUI [1,1])
C0020517 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0003250 (UMLS CUI [2,1])
C1527304 (UMLS CUI [2,2])
C0205082 (UMLS CUI [2,3])
C0332197 (UMLS CUI [2,4])
C0085581 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C0206062 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
Light Work Perform Able | Light work around the house Perform Able | Work Sedentary Perform Ability
Item
must be able to carry out work of light or sedentary nature (e.g. light house work, office work).
boolean
C2987220 (UMLS CUI [1,1])
C0884358 (UMLS CUI [1,2])
C0085732 (UMLS CUI [1,3])
C3842657 (UMLS CUI [2,1])
C0884358 (UMLS CUI [2,2])
C0085732 (UMLS CUI [2,3])
C0043227 (UMLS CUI [3,1])
C0205254 (UMLS CUI [3,2])
C0884358 (UMLS CUI [3,3])
C0085732 (UMLS CUI [3,4])
major surgery | Investigational New Drugs | Therapeutic radiology procedure Chest
Item
it must be at least 4 weeks since last major surgery or prior treatment with an investigational product and at least 12 weeks from any radiation therapy to the chest.
boolean
C0679637 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
C1522449 (UMLS CUI [3,1])
C0817096 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
women who are pregnant or breastfeeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Gender Pregnancy test positive
Item
women with a positive pregnancy test on enrollment or prior to study drug administration.
boolean
C0079399 (UMLS CUI [1,1])
C0240802 (UMLS CUI [1,2])
Malignant Neoplasms | Malignant Neoplasm Previous Disease Free of
Item
any concurrent malignancy (subjects with a previous malignancy but without evidence of disease for 5 years will be allowed to enter the trial).
boolean
C0006826 (UMLS CUI [1])
C0006826 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
C0012634 (UMLS CUI [2,3])
C0332296 (UMLS CUI [2,4])
CNS metastases Symptomatic | CNS metastases Uncontrolled
Item
symptomatic or uncontrolled metastases in the central nervous system (cns).
boolean
C0686377 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0686377 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
Peripheral Neuropathy
Item
peripheral neuropathy.
boolean
C0031117 (UMLS CUI [1])
Hematologic function Inadequate | Absolute neutrophil count | Platelet Count measurement | Hemoglobin measurement
Item
inadequate hematologic function defined by an absolute neutrophil count (anc) <1,500/mm^3, a platelet count <100,000/mm^3, or a hemoglobin level < 9g/dl.
boolean
C0221130 (UMLS CUI [1,1])
C0205412 (UMLS CUI [1,2])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0518015 (UMLS CUI [4])
Liver Dysfunction
Item
inadequate liver function.
boolean
C0086565 (UMLS CUI [1])
Abnormal renal function
Item
inadequate kidney function.
boolean
C0151746 (UMLS CUI [1])