Diffuse Large B-Cell Lymphoma
Item
histologically confirmed dlbcl
boolean
C0079744 (UMLS CUI [1])
Age
Item
age 70 years or less
boolean
C0001779 (UMLS CUI [1])
Untreated
Item
previously untreated
boolean
C0332155 (UMLS CUI [1])
ECOG performance status
Item
performance status: ecog 0-2
boolean
C1520224 (UMLS CUI [1])
advanced disease Ann Arbor lymphoma staging system | Non-Contiguous Disease Ann Arbor lymphoma staging system
Item
advanced stage: stage iii, iv, or non-contiguous stage ii
boolean
C0679246 (UMLS CUI [1,1])
C0432516 (UMLS CUI [1,2])
C1518352 (UMLS CUI [2,1])
C0432516 (UMLS CUI [2,2])
Measurable Disease Diameter Spiral CT
Item
measurable disease: 1 cm or more by spiral ct
boolean
C1513041 (UMLS CUI [1,1])
C1301886 (UMLS CUI [1,2])
C0860888 (UMLS CUI [1,3])
Liver function
Item
normal liver function
boolean
C0232741 (UMLS CUI [1])
Platelet Count measurement
Item
platelet count less than 75,000/microl within 14 days before enrollment.
boolean
C0032181 (UMLS CUI [1])
Absolute neutrophil count
Item
absolute neutrophil count of less than 1,500/microll within 14 days before enrollment.
boolean
C0948762 (UMLS CUI [1])
Creatinine measurement, serum | Estimation of creatinine clearance by Cockcroft-Gault formula | Creatinine clearance measurement
Item
cr more than 2.0 mg/dl and/or calculated or measured creatinine clearance less than 50 ml/min within 14 days before enrollment.
boolean
C0201976 (UMLS CUI [1])
C2711451 (UMLS CUI [2])
C0373595 (UMLS CUI [3])
Peripheral Neuropathy CTCAE Grades
Item
peripheral neuropathy of grade 2 or worse within 14 days before enrollment.
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Hypersensitivity bortezomib | Hypersensitivity Boron | Hypersensitivity Mannitol
Item
hypersensitivity to bortezomib, boron or mannitol.
boolean
C0020517 (UMLS CUI [1,1])
C1176309 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0006030 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0024730 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
female subject is pregnant or breast-feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Investigational New Drugs
Item
other investigational drugs with 14 days before enrollment
boolean
C0013230 (UMLS CUI [1])
Illness Serious Interferes with Study Subject Participation Status | Serious mental illness Interferes with Study Subject Participation Status
Item
serious medical or psychiatric illness likely to interfere with participation in this clinical study.
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C2348568 (UMLS CUI [1,4])
C3841614 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C2348568 (UMLS CUI [2,3])
Cardiovascular Disease Uncontrolled | Cardiovascular Disease Severe | Myocardial Infarction | Heart failure New York Heart Association Classification | Angina control - poor | Disorder of pericardium | Cardiac amyloidosis
Item
uncontrolled or severe cardiovascular disease, including mi within 6 months of enrolment, new york heart association (nyha) class iii or iv heart failure, uncontrolled angina, clinically significant pericardial disease, or cardiac amyloidosis
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0027051 (UMLS CUI [3])
C0018801 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C0421196 (UMLS CUI [5])
C0265122 (UMLS CUI [6])
C0268407 (UMLS CUI [7])