T-Cell Large Granular Lymphocyte Leukemia
Item
1. all patients must have a histologic or cytologic diagnosis of t-cell lgl leukemia as determined by the laboratory of pathology or hematology at the clinical center, national institutes of health
boolean
C1955861 (UMLS CUI [1])
Hemocytes Count Decreased | Granulocyte count | Platelet Count measurement | Hemoglobin measurement | Support Hematopoietic Patient need for | Blood Transfusion | Colony-Stimulating Factors
Item
2. all patients must have hemocytopenias such as granulocyte count less than 1,200/ul, platelet count less than 100,000/ul or hemoglobin less than 10 g/dl, or require hematopoietic support (transfusion or colony stimulating factors) to maintain counts at these or higher levels.
boolean
C0019000 (UMLS CUI [1,1])
C0750480 (UMLS CUI [1,2])
C0205216 (UMLS CUI [1,3])
C0857490 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0518015 (UMLS CUI [4])
C1521721 (UMLS CUI [5,1])
C0229601 (UMLS CUI [5,2])
C0686904 (UMLS CUI [5,3])
C0005841 (UMLS CUI [6])
C0009392 (UMLS CUI [7])
Measurable Disease | Evaluable Disease
Item
3. patients must have measurable or evaluable disease
boolean
C1513041 (UMLS CUI [1])
C1516986 (UMLS CUI [2])
Creatinine measurement, serum
Item
4. patients must have a creatinine of less than 2.0 mg/dl.
boolean
C0201976 (UMLS CUI [1])
Cytotoxic Chemotherapy Omission | Adrenal Cortex Hormones Stable
Item
5. omission of cytotoxic chemotherapy for 3 weeks prior to entry into the trial is required. however, patients receiving stable corticosteroids will be eligible.
boolean
C0677881 (UMLS CUI [1,1])
C3845736 (UMLS CUI [1,2])
C0001617 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
Age
Item
6. age greater than 18 years
boolean
C0001779 (UMLS CUI [1])
Karnofsky Performance Status
Item
7. karnofsky performance greater than 70%
boolean
C0206065 (UMLS CUI [1])
Life Expectancy
Item
8. patients must have a life expectancy of greater than 3 months.
boolean
C0023671 (UMLS CUI [1])
Informed Consent
Item
9. patients must be able to understand and sign an informed consent form.
boolean
C0021430 (UMLS CUI [1])
Gender Contraceptive methods
Item
10. all female patients must use adequate contraception during participation in this trial and for three months after completing therapy.
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Uncontrolled hypertension
Item
1. patients with uncontrolled hypertension
boolean
C1868885 (UMLS CUI [1])
Pregnancy | Breast Feeding | Cyclosporine | Premature Birth | Low Birth Weight
Item
2. pregnant and nursing patients are not eligible for the study as csa crosses the placenta. based on clinical use, premature births and low birth weight were consistently observed. breast-feeding is contraindicated because csa enters the blood milk and may possibly be administered to the child.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0010592 (UMLS CUI [3])
C0151526 (UMLS CUI [4])
C0024032 (UMLS CUI [5])
Immunodeficiency | HIV Seropositivity
Item
3. underlying immunodeficiency state including human immunodeficiency virus (hiv) seropositivity.
boolean
C0021051 (UMLS CUI [1])
C0019699 (UMLS CUI [2])
Hepatitis C antibody positive | Hepatitis B surface antigen positive
Item
4. positive for antibodies to hepatitis c or positive for hepatitis b surface antigen,
boolean
C0281863 (UMLS CUI [1])
C0149709 (UMLS CUI [2])
Comorbidity Serious Excludes Cyclosporine | Liver disease | Kidney Disease | Heart Disease | nervous system disorder | Lung disease | Communicable Disease | Metabolic Disease
Item
5. patients with serious intercurrent illnesses, concurrent hepatic, renal, cardiac, neurologic, pulmonary, infectious or metabolic disease of such severity that it would preclude the patients' ability to tolerate cyclosporine.
boolean
C0009488 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0332196 (UMLS CUI [1,3])
C0010592 (UMLS CUI [1,4])
C0023895 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
C0018799 (UMLS CUI [4])
C0027765 (UMLS CUI [5])
C0024115 (UMLS CUI [6])
C0009450 (UMLS CUI [7])
C0025517 (UMLS CUI [8])
Cyclosporine | Large Granular Lymphocytic Leukemia Absent response to treatment
Item
6. patients who received cyclosporine for lgl leukemia previously and failed to respond.
boolean
C0010592 (UMLS CUI [1])
C1522378 (UMLS CUI [2,1])
C0438286 (UMLS CUI [2,2])