age
Item
age > 49 years
boolean
C0001779 (UMLS CUI [1])
chronic knee discomfort, knee pain
Item
chronic knee discomfort based on the affirmative response to the question "during the past 6 months, have you had any pain in the knee more than half the days of the month ?"
boolean
C0745538 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0231749 (UMLS CUI [2])
womac pain subscale
Item
womac pain subscale score ≥ 1
boolean
C3472647 (UMLS CUI [1])
Osteoarthritis, Knee; Structure of femorotibial joint; Structure of patellofemoral joint | X-ray of knee, anteroposterior and lateral views | x-ray of knee: osteophytes | x-ray of knee: narrowing of joint space
Item
tibiofemoral or patellofemoral osteoarthritis on anteroposterior weight-bearing semi-flexed or lateral knee radiographs with at least one osteophyte and no significant joint-space-narrowing
boolean
C0409959 (UMLS CUI [1,1])
C0447795 (UMLS CUI [1,2])
C0447801 (UMLS CUI [1,3])
C2061628 (UMLS CUI [2])
C2021136 (UMLS CUI [3])
C2021131 (UMLS CUI [4])
clinical examination, knee pain
Item
clinical examination confirming knee pain or discomfort referable to the knee joint
boolean
C0031809 (UMLS CUI [1])
C0231749 (UMLS CUI [2])
prepared to refrain from use of glucosamine, chondroitin, same and doxycycline
Item
prepared to refrain from use of glucosamine, chondroitin, same and doxycycline
boolean
C0557021 (UMLS CUI [1,1])
C0017718 (UMLS CUI [1,2])
C0557021 (UMLS CUI [2,1])
C0008454 (UMLS CUI [2,2])
C0557021 (UMLS CUI [3,1])
C0036002 (UMLS CUI [3,2])
C0557021 (UMLS CUI [4,1])
C0013090 (UMLS CUI [4,2])
stable medication and/or supplement use
Item
stable medication and/or supplement use
boolean
C0013227 (UMLS CUI [1,1])
C2348609 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
use of glucosamine, chondroitin, diacerein or doxycycline
Item
use of glucosamine, chondroitin, diacerein or doxycycline within 14 weeks prior to randomization
boolean
C0017718 (UMLS CUI [1])
C0008454 (UMLS CUI [2])
C0057678 (UMLS CUI [3])
C0013090 (UMLS CUI [4])
comorbidity, limited protocol compliance
Item
serious medical conditions or impairments that, in the view of the investigator, would obstruct their participation in the trial
boolean
C0009488 (UMLS CUI [1])
C0439801 (UMLS CUI [2,1])
C0525058 (UMLS CUI [2,2])
limited compliance
Item
individuals who are expected not to comply with the study protocol
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
plan to permanently relocate from the region
Item
plan to permanently relocate from the region during the trial period
boolean
C2699029 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
knee arthroplasty
Item
planned knee arthroplasty in the study knee
boolean
C0086511 (UMLS CUI [1])
Pathology processes; Knee pain | Comorbidity
Item
active pathology of confounding origin which may cause pain, extending to the knee
boolean
C0677042 (UMLS CUI [1,1])
C0231749 (UMLS CUI [1,2])
C0009488 (UMLS CUI [2])
pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])
any contra-indication to having an mri scan
Item
any contra-indication to having an mri scan
boolean
C0024485 (UMLS CUI [1,1])
C1301624 (UMLS CUI [1,2])