Colorectal Carcinoma Advanced Local | Colorectal cancer metastatic
Item
histologically confirmed locally advanced or metastatic colorectal cancer
boolean
C0009402 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C0205276 (UMLS CUI [1,3])
C0948380 (UMLS CUI [2])
Measurable Disease | Evaluable Disease
Item
measurable or evaluable disease
boolean
C1513041 (UMLS CUI [1])
C1516986 (UMLS CUI [2])
ECOG performance status
Item
ecog performance status ≤ 2
boolean
C1520224 (UMLS CUI [1])
Age
Item
age 18 - 72 years
boolean
C0001779 (UMLS CUI [1])
Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Alkaline phosphatase measurement | Renal function | Creatinine measurement, serum | Bone Marrow function | Absolute neutrophil count | Platelet Count measurement
Item
adequate liver (bilirubin ≤ 1.5 unl, sgot/sgpt ≤ 4 unl, alp ≤ 2.5 unl), renal (creatinine ≤ 1.5 unl) and bone marrow (anc ≥ 1,500/mm3, plt ≥ 100,000/mm3) function
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C0201850 (UMLS CUI [5])
C0232804 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
C0005953 (UMLS CUI [8,1])
C0031843 (UMLS CUI [8,2])
C0948762 (UMLS CUI [9])
C0032181 (UMLS CUI [10])
Hemoptysis | Thromboembolism Risk Increased | Avastin Administration Observation
Item
patients with history of hemoptysis or with increased risk of thromboembolic events should be observed carefully due to administration of avastin
boolean
C0019079 (UMLS CUI [1])
C0040038 (UMLS CUI [2,1])
C0035647 (UMLS CUI [2,2])
C0205217 (UMLS CUI [2,3])
C1135130 (UMLS CUI [3,1])
C1533734 (UMLS CUI [3,2])
C0700325 (UMLS CUI [3,3])
Comprehension Study Protocol
Item
patients must be able to understand the nature of this study
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
Informed Consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
First line Chemotherapy
Item
previous 1st line chemotherapy
boolean
C1708063 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
Irinotecan Adjuvant Chemotherapy | Recurrent disease
Item
adjuvant chemotherapy with irinotecan regimen with relapse < 6 months after the completion
boolean
C0123931 (UMLS CUI [1,1])
C0085533 (UMLS CUI [1,2])
C0277556 (UMLS CUI [2])
Communicable Disease
Item
active infection
boolean
C0009450 (UMLS CUI [1])
Heart Disease Serious | Angina, Unstable | Congestive heart failure | Myocardial Infarction | Ventricular arrhythmia
Item
history of serious cardiac disease (unstable angina, congestive heart failure, myocardial infarction within the previous 6 months, ventricular arrhythmias)
boolean
C0018799 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0002965 (UMLS CUI [2])
C0018802 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
C0085612 (UMLS CUI [5])
Therapeutic radiology procedure | Therapeutic radiology procedure Bone Marrow Percentage
Item
previous radiotherapy within the last 4 weeks or > 25% of bone marrow
boolean
C1522449 (UMLS CUI [1])
C1522449 (UMLS CUI [2,1])
C0005953 (UMLS CUI [2,2])
C0439165 (UMLS CUI [2,3])
CNS metastases Unstable
Item
patients with unstable cns metastases
boolean
C0686377 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
Chronic diarrhea | Partial bowel obstruction
Item
patients with chronic diarrhea (at least for 3 months) or partial bowel obstruction
boolean
C0401151 (UMLS CUI [1])
C1328480 (UMLS CUI [2])
Second Primary Cancers | Skin carcinoma | Carcinoma in situ of uterine cervix
Item
second primary malignancy, except for non-melanoma skin cancer and in situ cervical cancer
boolean
C0751623 (UMLS CUI [1])
C0699893 (UMLS CUI [2])
C0851140 (UMLS CUI [3])
Mental disorder Protocol Compliance Exclusion | Social situation Protocol Compliance Exclusion
Item
psychiatric illness or social situation that would preclude study compliance
boolean
C0004936 (UMLS CUI [1,1])
C0525058 (UMLS CUI [1,2])
C2828389 (UMLS CUI [1,3])
C0748872 (UMLS CUI [2,1])
C0525058 (UMLS CUI [2,2])
C2828389 (UMLS CUI [2,3])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Age | Arterial thromboembolism | Myocardial Infarction | Angina, Unstable | Pulmonary Embolism
Item
patients > 65 years with history of arterial thromboembolic, myocardial infarction, unstable angina and pulmonary embolism
boolean
C0001779 (UMLS CUI [1])
C3544094 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0002965 (UMLS CUI [4])
C0034065 (UMLS CUI [5])