Gender | Breast adenocarcinoma | Inflammatory Breast Carcinoma
Item
female patients with histologically confirmed adenocarcinoma of the breast or inflammatory breast cancer
boolean
C0079399 (UMLS CUI [1])
C0858252 (UMLS CUI [2])
C0278601 (UMLS CUI [3])
TNM clinical staging
Item
clinical stage t 1-4, n 0-3, m0
boolean
C3258246 (UMLS CUI [1])
Fluorescent in Situ Hybridization Positive | Breast Carcinoma HER2 gene amplification
Item
fish+ her2 gene amplified breast cancer
boolean
C0162789 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
C0678222 (UMLS CUI [2,1])
C1512127 (UMLS CUI [2,2])
Age
Item
18 years or older
boolean
C0001779 (UMLS CUI [1])
Cardiac function
Item
normal cardiac function
boolean
C0232164 (UMLS CUI [1])
performance status
Item
performance status 0-2
boolean
C1518965 (UMLS CUI [1])
Chemotherapy Disease | Chemotherapy Malignant Neoplasms
Item
cannot have received any prior chemotherapy for this disease or cannot have received chemotherapy for any other cancer in the past 5 years.
boolean
C0392920 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0392920 (UMLS CUI [2,1])
C0006826 (UMLS CUI [2,2])
Breast Carcinoma Non-invasive
Item
previous diagnosis of noninvasive breast cancer is ok.
boolean
C0678222 (UMLS CUI [1,1])
C0205303 (UMLS CUI [1,2])
Bone Marrow function | Renal function | Liver function
Item
must have adequate bone marrow, renal and liver function.
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
Pregnancy | Breast Feeding
Item
pregnant or lactating females not allowed.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Peripheral Neuropathy Pre-existing CTCAE Grades
Item
preexisting peripheral neuropathy must be equal to or less than grade 1
boolean
C0031117 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C1516728 (UMLS CUI [1,3])
Tumor tissue sample Available Tissue analysis
Item
must have archived tumor tissue for tissue testing.
boolean
C0475358 (UMLS CUI [1,1])
C0470187 (UMLS CUI [1,2])
C3161513 (UMLS CUI [1,3])
Study Subject Participation Status Exclusion
Item
you cannot be in this study if you any of the following:
boolean
C2348568 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
Heart Diseases | Congestive heart failure New York Heart Association Classification
Item
history of cardiac disease, with new york heart association class ii or greater with congestive heart failure
boolean
C0018799 (UMLS CUI [1])
C0018802 (UMLS CUI [2,1])
C1275491 (UMLS CUI [2,2])
Myocardial Infarction | Cerebrovascular accident | Transient Ischemic Attack | Cardiac Arrhythmia Serious Requirement Pharmaceutical Preparations | Bleeding tendency | Blood Coagulation Disorders
Item
any heart attack, stroke or tias within the last 6 months or serious arrhythmias needing medication; no bleeding diathesis or coagulopathy.
boolean
C0027051 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0007787 (UMLS CUI [3])
C0003811 (UMLS CUI [4,1])
C0205404 (UMLS CUI [4,2])
C1514873 (UMLS CUI [4,3])
C0013227 (UMLS CUI [4,4])
C1458140 (UMLS CUI [5])
C0005779 (UMLS CUI [6])
Investigational New Drugs
Item
no prior investigational drug within the last 30 days
boolean
C0013230 (UMLS CUI [1])
trastuzumab | bevacizumab
Item
no prior trastuzumab or bevacizumab therapy
boolean
C0728747 (UMLS CUI [1])
C0796392 (UMLS CUI [2])
Clinical Trial Eligibility Criteria Additional
Item
there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons.
boolean
C1516637 (UMLS CUI [1,1])
C1524062 (UMLS CUI [1,2])