Age
Item
male or female 18 years or older
boolean
C0001779 (UMLS CUI [1])
DEPRESSIVE DISORDER MAJOR WITHOUT PSYCHOTIC FEATURE Moderate | Severe major depression without psychotic features
Item
dsm-iv diagnosis of major depressive disorder of at least moderate severity, but without psychotic features
boolean
C0743081 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0270457 (UMLS CUI [2])
Hamilton rating scale for depression
Item
ham-d 17 score of 18 or above
boolean
C0451203 (UMLS CUI [1])
Antidepressive Agents Trials Quantity | Selective Serotonin Reuptake Inhibitors | Depressive Symptoms Absent response to treatment
Item
have a documentable history of 2 prior adequate trials of antidepressants including an ssri without sufficient response. a clinically adequate trial is defined as having taken a minimum effective dose of an antidepressant for at least 3 weeks without a significant change in depressive symptoms.
boolean
C0003289 (UMLS CUI [1,1])
C0008976 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0360105 (UMLS CUI [2])
C0086132 (UMLS CUI [3,1])
C0438286 (UMLS CUI [3,2])
Serotonin Uptake Inhibitor Dose Adequate | venlafaxine | duloxetine
Item
must be currently on an serotonin uptake inhibitor (to include venlafaxine or duloxetine) at an adequate dose for at least 3 weeks.
boolean
C0162758 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205411 (UMLS CUI [1,3])
C0078569 (UMLS CUI [2])
C0245561 (UMLS CUI [3])
Informed Consent
Item
ability and willingness to provide consent for participation in the study.
boolean
C0021430 (UMLS CUI [1])
Medical condition Excludes Selective Serotonin Reuptake Inhibitors | Medical condition Excludes Risperidone | Medical condition Excludes Bupropion Extended Release
Item
any medical condition that would preclude treatment with an ssri, risperidone, or bupropion er
boolean
C3843040 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0360105 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C0073393 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0332196 (UMLS CUI [3,2])
C1252646 (UMLS CUI [3,3])
Medical condition Unstable Clinical Significance
Item
any clinically significant unstable medical condition
boolean
C3843040 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C2826293 (UMLS CUI [1,3])
Bipolar Disorder | Psychotic Disorder Primary
Item
diagnosis of bipolar disorder or a primary diagnosis of any psychotic disorder
boolean
C0005586 (UMLS CUI [1])
C0033975 (UMLS CUI [2,1])
C0205225 (UMLS CUI [2,2])
Psychotic symptom | Hallucinations | Delusions
Item
current psychotic symptoms (hallucination or delusions)
boolean
C0871189 (UMLS CUI [1])
C0018524 (UMLS CUI [2])
C0011253 (UMLS CUI [3])
Substance Use Disorders | Substance Dependence | Nicotine Dependence | Nicotine abuse | Caffeine dependence | Caffeine abuse
Item
alcohol or drug abuse or dependence in the last 3 months (excluding nicotine and caffeine dependence/abuse) or abuse within the last month
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
C0028043 (UMLS CUI [3])
C2363943 (UMLS CUI [4])
C1386553 (UMLS CUI [5])
C0679260 (UMLS CUI [6])
Antipsychotic Agent New | Bupropion Extended Release | Selective Serotonin Reuptake Inhibitors | Absent response to treatment
Item
documented non-response to the combination of a novel antipsychotic or bupropion er and a ssri
boolean
C0040615 (UMLS CUI [1,1])
C0205314 (UMLS CUI [1,2])
C1252646 (UMLS CUI [2])
C0360105 (UMLS CUI [3])
C0438286 (UMLS CUI [4])
Psychotropic Drugs | Selective Serotonin Reuptake Inhibitors | zolpidem
Item
concomitant use of any psychotropic other than an ssri or zolpidem (prn for sleep)
boolean
C0033978 (UMLS CUI [1])
C0360105 (UMLS CUI [2])
C0078839 (UMLS CUI [3])
Hamilton rating scale for depression | At risk for suicide Significant
Item
score of 4 on the suicide item of the ham-d scale and determination by the investigator of significant suicide risk
boolean
C0451203 (UMLS CUI [1])
C0563664 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
Hypersensitivity Risperidone | Hypersensitivity Bupropion Extended Release
Item
known sensitivity to risperidone or bupropion er
boolean
C0020517 (UMLS CUI [1,1])
C0073393 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C1252646 (UMLS CUI [2,2])