Parkinson Disease | Patients Quantity
Item
thirty patients with pd will be included in the study.
boolean
C0030567 (UMLS CUI [1])
C0030705 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Parkinson Disease | Medical History | Physical Examination | Neurologic Examination | Levodopa Response | Dopaminergic Agents Response | Laboratory Procedures | MRI Scans
Item
the diagnosis of pd is based on medical history, physical and neurological examinations, response to levodopa or dopaminergic drugs, and laboratory tests and mri scans to exclude other diseases.
boolean
C0030567 (UMLS CUI [1])
C0262926 (UMLS CUI [2])
C0031809 (UMLS CUI [3])
C0027853 (UMLS CUI [4])
C0023570 (UMLS CUI [5,1])
C1704632 (UMLS CUI [5,2])
C0013036 (UMLS CUI [6,1])
C1704632 (UMLS CUI [6,2])
C0022885 (UMLS CUI [7])
C0917711 (UMLS CUI [8])
Unified Parkinson's Disease Rating Scale Questionnaire | Mini-mental state examination | Disability motor Mild | Disability motor Moderate | Impaired cognition
Item
patients will be assessed with the unified parkinson's disease rating scale (updrs) and mini-mental state exam (mmse). only patients with mild to moderate motor disability (udrs less than or equal to 40) and without cognitive impairment (mmt score greater than or equal to 25) will be investigated.
boolean
C3639721 (UMLS CUI [1])
C0451306 (UMLS CUI [2])
C0231170 (UMLS CUI [3,1])
C1513492 (UMLS CUI [3,2])
C2945599 (UMLS CUI [3,3])
C0231170 (UMLS CUI [4,1])
C1513492 (UMLS CUI [4,2])
C0205081 (UMLS CUI [4,3])
C0338656 (UMLS CUI [5])
Pharmaceutical Preparations Withdrawn
Item
patients will be studied only after their medication has been withdrawn for at least 12 hours.
boolean
C0013227 (UMLS CUI [1,1])
C2349954 (UMLS CUI [1,2])
Study Subject Medical record number Valid Clinic
Item
all subjects participating in the study should have a valid clinical center medical record number.
boolean
C0681850 (UMLS CUI [1,1])
C1301894 (UMLS CUI [1,2])
C2349099 (UMLS CUI [1,3])
C0442592 (UMLS CUI [1,4])
fMRI experiment
Item
the fmri experiment will follow the standard operating procedures of the hmcs neuroimaging group.
boolean
C0376335 (UMLS CUI [1,1])
C0681814 (UMLS CUI [1,2])
Mental disorders | Disability motor Severe
Item
subjects with psychiatric disorders or severe motor disabilities will be excluded.
boolean
C0004936 (UMLS CUI [1])
C0231170 (UMLS CUI [2,1])
C1513492 (UMLS CUI [2,2])
C0205082 (UMLS CUI [2,3])
Artificial cardiac pacemaker | Cardiac defibrillator | Defibrillators neural | Aneurysm clip | Metallic foreign body orbital | Insulin pump | Cochlear Implants | Metallic Object
Item
subjects with pacemakers, cardiac or neural defibrillators, intracranial aneurysm clips, intraorbital metallic structures, insulin pumps, cochlear implants, and other metallic objects will not be scanned.
boolean
C0030163 (UMLS CUI [1])
C1391956 (UMLS CUI [2])
C0180307 (UMLS CUI [3,1])
C3714606 (UMLS CUI [3,2])
C0179977 (UMLS CUI [4])
C1720389 (UMLS CUI [5,1])
C1183518 (UMLS CUI [5,2])
C1140609 (UMLS CUI [6])
C0009199 (UMLS CUI [7])
C2826620 (UMLS CUI [8])
Pregnancy Excluded Magnetic Resonance Imaging | Childbearing Potential Pregnancy test negative
Item
women who are pregnant are excluded from mri because the safety of the fetus in the presence of high magnetic fields is not established. therefore, all women of childbearing potential will have a pregnancy test performed, which must be negative, before proceeding.
boolean
C0032961 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
C3831118 (UMLS CUI [2,1])
C0427780 (UMLS CUI [2,2])
Age
Item
subjects under age 18 will be excluded.
boolean
C0001779 (UMLS CUI [1])