Multiple Sclerosis, Secondary Progressive | Multiple Sclerosis, Primary Progressive | Multiple Sclerosis, Progressive Relapsing
Item
diagnosis of secondary progressive (spms), primary progressive (ppms) or progressive relapsing (prms) multiple sclerosis
boolean
C0751965 (UMLS CUI [1])
C0751964 (UMLS CUI [2])
C0393666 (UMLS CUI [3])
Multiple Sclerosis
Item
a diagnosis of ms will be established by fulfilling criteria "recommended diagnostic criteria for multiple sclerosis: guidelines from the internal panel on the diagnosis of multiple sclerosis"
boolean
C0026769 (UMLS CUI [1])
Multiple Sclerosis Subtype | natural history of disease
Item
the subtype of ms will be established by the natural history of the disease
boolean
C0026769 (UMLS CUI [1,1])
C0449560 (UMLS CUI [1,2])
C0599879 (UMLS CUI [2])
Age
Item
age >18 but < 75 years
boolean
C0001779 (UMLS CUI [1])
EDSS | Standard of Care Quantity | Interferon beta-1a | interferon beta-1b | glatiramer acetate | Mitoxantrone | Plasmapheresis | Immunoglobulins, Intravenous
Item
an extended disability status scale (edss) score of >3.5 after two standard treatment regimens ifnb1a ifnb1b glatiramer acetate mitoxanthrone steroids, plasmapheresis or ivig individually or in combination constitute a single treatment regimen
boolean
C0451246 (UMLS CUI [1])
C2936643 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0254119 (UMLS CUI [3])
C0244713 (UMLS CUI [4])
C0289884 (UMLS CUI [5])
C0026259 (UMLS CUI [6])
C0032134 (UMLS CUI [7])
C0085297 (UMLS CUI [8])
Left ventricular ejection fraction
Item
patient must have a left ventricular ejection fraction of > 45%
boolean
C0428772 (UMLS CUI [1])
Creatinine measurement, serum
Item
serum creatinine <3mg/dl
boolean
C0201976 (UMLS CUI [1])
Childbearing Potential Serum Beta-HCG Test | Cyclophosphamide
Item
for women of childbearing potential, serum βhcg (less than seven days before start of cyclophosphamide)
boolean
C3831118 (UMLS CUI [1,1])
C1255526 (UMLS CUI [1,2])
C0010583 (UMLS CUI [2])
Study Subject Participation Status Willing
Item
willingness to participate in a clinical trial
boolean
C2348568 (UMLS CUI [1,1])
C0600109 (UMLS CUI [1,2])
pre-terminal | Moribund
Item
patients who are preterminal or moribund
boolean
C0184771 (UMLS CUI [1])
C0424547 (UMLS CUI [2])
Malignant Neoplasms
Item
patients with active malignancies
boolean
C0006826 (UMLS CUI [1])
Chromosome Aberrations | Peripheral blood Cell Count Suggestive of MYELODYSPLASTIC SYNDROME
Item
patients with chromosomal abnormalities or peripheral blood counts suggestive of myelodysplastic syndrome
boolean
C0008625 (UMLS CUI [1])
C0229664 (UMLS CUI [2,1])
C0005771 (UMLS CUI [2,2])
C0332299 (UMLS CUI [2,3])
C3463824 (UMLS CUI [2,4])
Bacterial Infections Requirement Microbicides Oral | Mycoses Requirement Microbicides Oral | Bacterial Infections Requirement Intravenous injection of antimicrobial substance | Mycoses Requirement Intravenous injection of antimicrobial substance
Item
patients with active bacterial or fungal infections requiring oral or intravenous antimicrobials are not eligible until resolution of the infection
boolean
C0004623 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C1136254 (UMLS CUI [1,3])
C1527415 (UMLS CUI [1,4])
C0026946 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C1136254 (UMLS CUI [2,3])
C1527415 (UMLS CUI [2,4])
C0004623 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C1960380 (UMLS CUI [3,3])
C0026946 (UMLS CUI [4,1])
C1514873 (UMLS CUI [4,2])
C1960380 (UMLS CUI [4,3])
Pregnancy | Breast Feeding
Item
pregnant women and breast-feeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
intolerance to G-CSF
Item
patients with known intolerance to g-csf
boolean
C1744706 (UMLS CUI [1,1])
C0079459 (UMLS CUI [1,2])