Multiple Myeloma | Multiple Myeloma Primary Refractory | Multiple Myeloma partial response Consolidation | Multiple Myeloma Decrease | Serum M Protein | Urine M Protein | Immunofixation electrophoresis | Plasmacytosis | Marrow aspirate | Bone marrow biopsy | Recurrent disease Post Prior Therapy
Item
1. patients with multiple myeloma in any of the following disease categories: a) primary refractory disease b) consolidation of a partial remission (defined as a decrease but continued presence of monoclonal protein on serum and urine immunofixation electrophoresis, and/or the presence of plasmacytosis on bone marrow aspirate and biopsy) c) all patients relapsing after prior therapy .
boolean
C0026764 (UMLS CUI [1])
C0026764 (UMLS CUI [2,1])
C2347678 (UMLS CUI [2,2])
C0026764 (UMLS CUI [3,1])
C1521726 (UMLS CUI [3,2])
C0702116 (UMLS CUI [3,3])
C0026764 (UMLS CUI [4,1])
C0547047 (UMLS CUI [4,2])
C0229671 (UMLS CUI [5,1])
C0700271 (UMLS CUI [5,2])
C0042036 (UMLS CUI [6,1])
C0700271 (UMLS CUI [6,2])
C1611269 (UMLS CUI [7])
C0085663 (UMLS CUI [8])
C0857285 (UMLS CUI [9])
C0005954 (UMLS CUI [10])
C0277556 (UMLS CUI [11,1])
C0687676 (UMLS CUI [11,2])
C1514463 (UMLS CUI [11,3])
Age
Item
2. age up to 70 years.
boolean
C0001779 (UMLS CUI [1])
Zubrod Performance Status
Item
3. zubrod performance status (ps) of <2.
boolean
C3714786 (UMLS CUI [1])
Left ventricular ejection fraction | Cardiac Arrhythmia Uncontrolled | Heart Disease Symptomatic
Item
4. left ventricular ejection fraction >40%. no uncontrolled arrhythmias or symptomatic cardiac disease.
boolean
C0428772 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
Forced vital capacity | FEV1 | Carbon Monoxide Diffusing Capability Test | Lung disease Symptomatic
Item
5. forced vital capacity (fvc); forced expiratory volume in 1 second (fev1), forced vital capacity (fvc) and carbon monoxide diffusing capacity (dl co) >40%. no symptomatic pulmonary disease.
boolean
C1287681 (UMLS CUI [1])
C0748133 (UMLS CUI [2])
C1516251 (UMLS CUI [3])
C0024115 (UMLS CUI [4,1])
C0231220 (UMLS CUI [4,2])
Serum bilirubin measurement | Alanine aminotransferase measurement | Chronic Hepatitis Evidence | Chronic Liver Cirrhosis Evidence | effusion | Ascites | Drainage
Item
6. serum bilirubin <2 times upper limit of normal, sgpt <4 times upper limit of normal. no evidence of chronic active hepatitis or cirrhosis. no effusion or ascites >1l prior to drainage.
boolean
C0428441 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
C0019189 (UMLS CUI [3,1])
C3887511 (UMLS CUI [3,2])
C0023890 (UMLS CUI [4,1])
C0205191 (UMLS CUI [4,2])
C3887511 (UMLS CUI [4,3])
C0013687 (UMLS CUI [5])
C0003962 (UMLS CUI [6])
C0013103 (UMLS CUI [7])
HIV negative
Item
7. hiv-negative.
boolean
C0481430 (UMLS CUI [1])
Pregnancy
Item
8. patient is not pregnant.
boolean
C0032961 (UMLS CUI [1])
Informed Consent
Item
9. patient or guardian able to sign informed consent.
boolean
C0021430 (UMLS CUI [1])
QTc
Item
10. corrected qt interval less than 500 msec.
boolean
C0860814 (UMLS CUI [1])
QTc
Item
1. corrected qt interval greater than 500 msec
boolean
C0860814 (UMLS CUI [1])
In complete remission | Serum M Protein Absent | Urine M Protein Absent | Immunofixation electrophoresis | Plasmacytosis Absent | Marrow aspirate | Bone marrow biopsy
Item
2. patients in complete remission (defined as the absence of monoclonal protein on serum and urine immunofixation electrophoresis, and the absence of plasmacytosis in bone marrow aspirate and biopsy).
boolean
C0677874 (UMLS CUI [1])
C0229671 (UMLS CUI [2,1])
C0700271 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0042036 (UMLS CUI [3,1])
C0700271 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C1611269 (UMLS CUI [4])
C0085663 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0857285 (UMLS CUI [6])
C0005954 (UMLS CUI [7])
Non-secretory myeloma
Item
3. patients with non-secretory myeloma.
boolean
C0456845 (UMLS CUI [1])