Multiple Myeloma Symptomatic Requirement Therapeutic procedure
Item
patients must have symptomatic multiple myeloma requiring treatment
boolean
C0026764 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
Single Autologous Transplantation Approved | Double Autologous Transplantation Approved
Item
patients must have been approved for single or tandem autologous transplant
boolean
C0040736 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
C0205540 (UMLS CUI [1,3])
C0040736 (UMLS CUI [2,1])
C0205173 (UMLS CUI [2,2])
C0205540 (UMLS CUI [2,3])
Age | Renal Insufficiency | Creatinine measurement, serum | Creatinine clearance measurement
Item
patients must be > or = 65 years of age or diagnosed with renal insufficiency, defined as having a creatinine > 3 mg/dl or a creatinine clearance < 30 ml/minute
boolean
C0001779 (UMLS CUI [1])
C1565489 (UMLS CUI [2])
C0201976 (UMLS CUI [3])
C0373595 (UMLS CUI [4])
Chronic Obstructive Airway Disease | Restrictive pulmonary disease chronic | Pulmonary function tests | FEV1 | FVC | DLCO
Item
patients must not have a history of chronic obstructive or chronic restrictive pulmonary disease. patients must have adequate pulmonary function studies > 50% of predicted on mechanical aspects (fev1, fvc, etc) and diffusion capacity (dlco) > 50% of predicted,
boolean
C0024117 (UMLS CUI [1])
C0877013 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
C0024119 (UMLS CUI [3])
C0748133 (UMLS CUI [4])
C1287681 (UMLS CUI [5])
C1516251 (UMLS CUI [6])
Left ventricular ejection fraction | Echocardiography | MUGA
Item
patients must have an echo or muga performed within 60 days prior to registration, lvef > 40%.
boolean
C0428772 (UMLS CUI [1])
C0013516 (UMLS CUI [2])
C0521317 (UMLS CUI [3])
Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
bilirubin, sgot, sgpt must be less than 1.5 times the upper limit of normal
boolean
C1278039 (UMLS CUI [1])
C0201899 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
Disease Response | M Protein Serum | M Protein In Urine | BONE MARROW PLASMACYTOSIS | Plasma Cells Percentage | Plasmacytosis Extramedullary | Lesion Focal Due to Multiple Myeloma | Magnetic Resonance Imaging | Positron-Emission Tomography
Item
patients must have evaluable myeloma marker for response such as: *serum m protein >1g/dl or urine m protein >1g/24 hours and/or; *bone marrow plasmacytosis with >20% plasma cells and/or; *extramedullary plasmacytosis; *mri/pet scan has focal lesions due to myeloma.
boolean
C1704632 (UMLS CUI [1])
C0700271 (UMLS CUI [2,1])
C0229671 (UMLS CUI [2,2])
C0700271 (UMLS CUI [3,1])
C0042037 (UMLS CUI [3,2])
C0238803 (UMLS CUI [4])
C0032112 (UMLS CUI [5,1])
C0439165 (UMLS CUI [5,2])
C0085663 (UMLS CUI [6,1])
C1517060 (UMLS CUI [6,2])
C0221198 (UMLS CUI [7,1])
C0205234 (UMLS CUI [7,2])
C0678226 (UMLS CUI [7,3])
C0026764 (UMLS CUI [7,4])
C0024485 (UMLS CUI [8])
C0032743 (UMLS CUI [9])
DT PACE regimen Ability | Cisplatin
Item
patients must be able to receive full doses of dt-pace, in the opinion of the treating investigator, with the exception of cisplatin.
boolean
C1880242 (UMLS CUI [1,1])
C0085732 (UMLS CUI [1,2])
C0008838 (UMLS CUI [2])
performance status | Patient status Due to Multiple Myeloma
Item
patients must have a performance status of 0-2 based on swog criteria unless the patient's status is due to active myeloma
boolean
C1518965 (UMLS CUI [1])
C0449437 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0026764 (UMLS CUI [2,3])
Informed Consent
Item
all patients must be informed of the investigational nature of the study and have signed an irb-approved informed consent in accordance with institutional and federal guidelines.
boolean
C0021430 (UMLS CUI [1])
Serum transaminase increased | Bilirubin, direct measurement
Item
serum transaminases > 1.5 x uln and direct bilirubin > 1.5 mg/dl
boolean
C0859350 (UMLS CUI [1])
C0201916 (UMLS CUI [2])
HIV Seropositivity | Hepatitis B | Hepatitis C | Serology positive Causing Quantitative PCR analysis
Item
hiv positive or active hepatitis b or hepatitis c infection; (if serology is positive a quantitative pcr will be done).
boolean
C0019699 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
C0242089 (UMLS CUI [4,1])
C0678227 (UMLS CUI [4,2])
C2733022 (UMLS CUI [4,3])
Life Expectancy Due to Malignant Neoplasms
Item
patients with a prior malignancy in whom life expectancy is more likely to be determined by the prior malignancy than the myeloma. patients must not currently be receiving therapy for the prior malignancy.
boolean
C0023671 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0006826 (UMLS CUI [1,3])
Pregnancy | Breast Feeding | Childbearing Potential Pregnancy test negative | Fertility Contraceptive methods
Item
pregnant or nursing women. women of childbearing potential must have a negative pregnancy test documented within one week of registration. women/men of reproductive potential may not participate unless they have agreed to use an effective contraceptive method.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0427780 (UMLS CUI [3,2])
C0015895 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])