Life Expectancy
Item
life expectancy more than three months
boolean
C0023671 (UMLS CUI [1])
Multiple Myeloma
Item
diagnosed with multiple myeloma (mm)
boolean
C0026764 (UMLS CUI [1])
Conventional Treatment Multiple Myeloma Response | Recurrent disease | Therapeutic procedure Recent Multiple Myeloma Unresponsive to Treatment
Item
relapsed following a response to any conventional mm therapy, and refractory to their most recent mm therapy
boolean
C2945704 (UMLS CUI [1,1])
C0026764 (UMLS CUI [1,2])
C1704632 (UMLS CUI [1,3])
C0277556 (UMLS CUI [2])
C0087111 (UMLS CUI [3,1])
C0332185 (UMLS CUI [3,2])
C0026764 (UMLS CUI [3,3])
C0205269 (UMLS CUI [3,4])
Karnofsky Performance Status
Item
karnofsky performance status = 60
boolean
C0206065 (UMLS CUI [1])
Ischemia | Conduction system abnormalities New | Electrocardiography Evidence
Item
no electrocardiographic evidence of acute ischemia or new conduction system abnormalities
boolean
C0022116 (UMLS CUI [1])
C0151236 (UMLS CUI [2,1])
C0205314 (UMLS CUI [2,2])
C1623258 (UMLS CUI [3,1])
C3887511 (UMLS CUI [3,2])
Myocardial Infarction
Item
no history of myocardial infarction within last 6 months
boolean
C0027051 (UMLS CUI [1])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
serum concentrations of aspartate aminotransferase (ast) and alanine aminotransferase (alt) = 3x upper limit of normal (uln)
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Serum total bilirubin measurement
Item
total serum bilirubin = 2x uln
boolean
C1278039 (UMLS CUI [1])
Estimation of creatinine clearance by Cockcroft-Gault formula | Creatinine clearance measurement
Item
calculated or measured creatinine clearance >30 ml/min
boolean
C2711451 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Platelet Count measurement
Item
platelet count = 30 x 10(9)/l
boolean
C0032181 (UMLS CUI [1])
Hemoglobin
Item
hemoglobin concentration = 8 g/dl
boolean
C0019046 (UMLS CUI [1])
White Blood Cell Count procedure
Item
white blood cell count = 2.0 x 10(9)/l
boolean
C0023508 (UMLS CUI [1])
Non-secretory myeloma | Leukemia, Plasma Cell | POEMS Syndrome | Plasma cell dyscrasia with polyneuropathy | Organomegaly | Endocrine System Diseases | M Protein Change | skin; change
Item
patients with non-secretory myeloma, plasma cell leukemia, or poems syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, m-protein and skin changes)
boolean
C0456845 (UMLS CUI [1])
C0023484 (UMLS CUI [2])
C0085404 (UMLS CUI [3])
C0272255 (UMLS CUI [4])
C4054315 (UMLS CUI [5])
C0014130 (UMLS CUI [6])
C0700271 (UMLS CUI [7,1])
C0392747 (UMLS CUI [7,2])
C1399787 (UMLS CUI [8])
major surgery
Item
major surgery within four weeks of enrollment
boolean
C0679637 (UMLS CUI [1])
Serum calcium increased Severe
Item
severe elevated serum calcium
boolean
C0595928 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Heart failure
Item
heart failure
boolean
C0018801 (UMLS CUI [1])
Chemotherapy | Immunotherapy | Therapeutic radiology procedure | Investigational New Drugs
Item
receipt of chemotherapy within 21 days before enrollment, receiving immunotherapy, radiation therapy, or other investigational agents
boolean
C0392920 (UMLS CUI [1])
C0021083 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
C0013230 (UMLS CUI [4])
Adrenal Cortex Hormones | Prednisone
Item
receipt of corticosteroids equivalent to more than 10 mg/day of prednisone within two weeks before enrollment
boolean
C0001617 (UMLS CUI [1])
C0032952 (UMLS CUI [2])
Hypersensitivity bortezomib | Hypersensitivity Boron | Mannitol allergy
Item
known allergies to agents used in bortezomib (e.g., boron or mannitol)
boolean
C0020517 (UMLS CUI [1,1])
C1176309 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0006030 (UMLS CUI [2,2])
C0571922 (UMLS CUI [3])
Poor hypertension control | poorly controlled diabetes mellitus | Illness Serious Interferes with Protocol Compliance | Serious mental illness Interferes with Protocol Compliance
Item
poorly controlled hypertension, diabetes mellitus, or other serious medical or psychiatric illness that could potentially interfere with the completion of treatment according to this protocol
boolean
C0421190 (UMLS CUI [1])
C0554876 (UMLS CUI [2])
C0221423 (UMLS CUI [3,1])
C0205404 (UMLS CUI [3,2])
C0521102 (UMLS CUI [3,3])
C0525058 (UMLS CUI [3,4])
C3841614 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])