Age | Informed Consent
Item
all subjects will be between 18 and 50 years old. male and female subjects will be included. all subjects must be able to give written informed consent prior to participation in this study.
boolean
C0001779 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
Volunteer sample | Age | Major Depressive Disorder Primary | Feeling depressed | Major Depressive Disorder Recurrent | major depressive episode | First Degree Relative | Major Depressive Disorder | Manic | Alcoholic Intoxication, Chronic | Antisocial Personality Disorder
Item
mdd depressed sample: twenty five subjects (ages 18-50) male and female will be selected, with primary mdd currently depressed as defined by dsm-iv criteria for recurrent mdd, in a current major depressive episode and who have a first degree relative with mdd but no first degree relatives with mania, alcoholism, or antisocial personality disorder.
boolean
C0150095 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C1269683 (UMLS CUI [3,1])
C0205225 (UMLS CUI [3,2])
C0497307 (UMLS CUI [4])
C1269683 (UMLS CUI [5,1])
C2945760 (UMLS CUI [5,2])
C0024517 (UMLS CUI [6])
C1517194 (UMLS CUI [7])
C1269683 (UMLS CUI [8])
C0338831 (UMLS CUI [9])
C0001973 (UMLS CUI [10])
C0003431 (UMLS CUI [11])
Volunteer sample | Age | Major depression in remission | Antidepressive Agents | Hamilton rating scale for depression | Depressive Symptom Clinical Significance Quantity
Item
mdd remission sample: twenty subjects (ages 18-50) male and female will be selected. remission is defined as a period of at least three months during which the subject has not taken an antidepressant agent, with hamilton depression rating scale (hdrs; 21-item; hamilton 1960) scores in the non-depressed range (less than 8), and with no more than one clinically significant depressive symptom.
boolean
C0150095 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0270461 (UMLS CUI [3])
C0003289 (UMLS CUI [4])
C0451203 (UMLS CUI [5])
C0086132 (UMLS CUI [6,1])
C2826293 (UMLS CUI [6,2])
C1265611 (UMLS CUI [6,3])
Volunteer sample | Age | Bipolar I disorder | Bipolar II disorder | Feeling depressed
Item
bipolar depressed sample: twenty five subjects (ages 18-50) male and female will be selected who meet dsm-iv criteria for bipolar i or ii disorder and are currently in a depressed phase.
boolean
C0150095 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0853193 (UMLS CUI [3])
C0236788 (UMLS CUI [4])
C0497307 (UMLS CUI [5])
Healthy Volunteers Control Group | Age | Mental disorders Major | Gender | Handedness | Intelligence quotient | First Degree Relative | Mood Disorders
Item
healthy control sample: thirty subjects (ages 18-50) male and female who have not met criteria for any major psychiatric disorder will be selected. from this large sample a control subject will be matched to each depressed subject for age, gender, handedness and iq. the control subjects will have no known first degree relatives with mood disorders.
boolean
C1708335 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0001779 (UMLS CUI [2])
C0004936 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
C0079399 (UMLS CUI [4])
C0023114 (UMLS CUI [5])
C0456149 (UMLS CUI [6])
C1517194 (UMLS CUI [7])
C0525045 (UMLS CUI [8])
Disease Major | nervous system disorder Major | Psychotropic Drugs | Pharmaceutical Preparations Affecting Cerebral Blood Flow | Pharmaceutical Preparations Affecting Metabolism | Fluoxetine | Prozac
Item
individuals with any major medical or neurological disorder or who have received psychotropic drugs or medication likely to influence cerebral blood flow or metabolism within 3 weeks (8 weeks for fluoxetine [prozac]), of scanning.
boolean
C0012634 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0027765 (UMLS CUI [2,1])
C0205164 (UMLS CUI [2,2])
C0033978 (UMLS CUI [3])
C0013227 (UMLS CUI [4,1])
C0392760 (UMLS CUI [4,2])
C0428714 (UMLS CUI [4,3])
C0013227 (UMLS CUI [5,1])
C0392760 (UMLS CUI [5,2])
C0025519 (UMLS CUI [5,3])
C0016365 (UMLS CUI [6])
C0162373 (UMLS CUI [7])
Rapid cycling bipolar I disorder | Psychotic Disorders
Item
bipolar subjects with rapid cycling or with current psychosis will be excluded from the protocol.
boolean
C2063820 (UMLS CUI [1])
C0033975 (UMLS CUI [2])
Patients untreated | Pharmaceutical Preparations Discontinued Due to Lack of Efficacy | Pharmaceutical Preparations Discontinued Due to Non-Compliance | Pharmaceutical Preparations Discontinued Due to Physician order | Pharmaceutical Preparations Discontinued Due to Other reasons
Item
effective treatment will not be discontinued for the purposes of this protocol, subjects will be identified who have never been treated or who have discontinued medication due to lack of efficacy, noncompliance, physician order or other reasons prior to study entry.
boolean
C0030705 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0013227 (UMLS CUI [2,1])
C1444662 (UMLS CUI [2,2])
C0678226 (UMLS CUI [2,3])
C0235828 (UMLS CUI [2,4])
C0013227 (UMLS CUI [3,1])
C1444662 (UMLS CUI [3,2])
C0678226 (UMLS CUI [3,3])
C0376405 (UMLS CUI [3,4])
C0013227 (UMLS CUI [4,1])
C1444662 (UMLS CUI [4,2])
C0678226 (UMLS CUI [4,3])
C1546491 (UMLS CUI [4,4])
C0013227 (UMLS CUI [5,1])
C1444662 (UMLS CUI [5,2])
C0678226 (UMLS CUI [5,3])
C3845511 (UMLS CUI [5,4])
Substance Use Disorders | Substance Dependence Lifetime
Item
individuals who meet dsm-iv criteria for alcohol and/or substance abuse within 1 year prior to screening or lifetime history of substance dependence.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2,1])
C4071830 (UMLS CUI [2,2])
Childbearing Potential Pregnancy | Childbearing Potential Pregnancy test positive
Item
women of childbearing potential who are known to be pregnant or who have a positive pregnancy test.
boolean
C3831118 (UMLS CUI [1,1])
C0032961 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0240802 (UMLS CUI [2,2])
Feeling suicidal Serious
Item
individuals who have experienced serious suicidal ideation within the past 2 months.
boolean
C0424000 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Exclusion General Magnetic Resonance Imaging | Artificial cardiac pacemaker | Implantation Metallic foreign body
Item
general exclusions for mri imaging, such as having had a cardiac pacemaker or ferromagnetic object implanted through surgical intervention or accident (for example: shrapnel).
boolean
C2828389 (UMLS CUI [1,1])
C0205246 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
C0030163 (UMLS CUI [2])
C0021107 (UMLS CUI [3,1])
C1720389 (UMLS CUI [3,2])