Age
Item
1. age 18 - 65 years.
boolean
C0001779 (UMLS CUI [1])
Mantle cell lymphoma stage ii-iv, phenotypic expression of cd5, cd20 and cyclin-d1 and t(11;14) translocation in most cases
Item
2. histologically confirmed (according to the who classification) mantle cell lymphoma stage ii-iv at time point of diagnosis. the diagnosis has to be confirmed by phenotypic expression of cd5, cd20 and cyclin-d1 and most cases will have t(11;14) translocation.
boolean
C0334634 (UMLS CUI [1])
C1300072 (UMLS CUI [2])
C3538992 (UMLS CUI [3])
C3540684 (UMLS CUI [4])
C0174680 (UMLS CUI [5])
C1515705 (UMLS CUI [6])
no previous treatment for lymphoma except radiotherapy or one cycle of any regimen
Item
3. no previous treatment for lymphoma except radiotherapy or one cycle of any regimen and except patients treated in the previous phase ii study who can be transferred to nlg-mcl-iii before evaluation at week 15.
boolean
C1522449 (UMLS CUI [1])
C1302181 (UMLS CUI [2,1])
C0750480 (UMLS CUI [2,2])
WHO performance status
Item
4. who performance status of 0 - 3.
boolean
C1298650 (UMLS CUI [1])
Life expectancy
Item
5. life expectancy of more than 3 months.
boolean
C0023671 (UMLS CUI [1])
Informed consent
Item
6. written informed consent.
boolean
C0021430 (UMLS CUI [1])
Cardiac function
Item
1. severe cardiac disease: cardiac function grade 3-4 (appendix 1).
boolean
C0232164 (UMLS CUI [1])
Impaired liver, renal or other organ function
Item
2. impaired liver, renal or other organ function not caused by lymphoma, which will interfere with the treatment.
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0232164 (UMLS CUI [3])
C1321605 (UMLS CUI [4,1])
C0439801 (UMLS CUI [4,2])
C0009488 (UMLS CUI [4,3])
Pregnancy/lactation
Item
3. pregnancy/lactation
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Contraceptive methods
Item
4. men or woman of reproductive potential not agreeing to use acceptable method of birth control during treatment and for six moths after completion of treatment.
boolean
C0700589 (UMLS CUI [1])
HIV
Item
5. known hiv positivity
boolean
C0019699 (UMLS CUI [1])
Malignancy
Item
6. any other prior malignancy than non-melanoma skin cancer or stage 0 (in situ) cervical carcinoma.
boolean
C0006826 (UMLS CUI [1])
Seropositivity for hcv, hbsag or other active infection
Item
7. known seropositivity for hcv, hbsag or other active infection uncontrolled by treatment.
boolean
C0019196 (UMLS CUI [1])
C0019168 (UMLS CUI [2])
C0009450 (UMLS CUI [3])
psychiatric illness
Item
8. psychiatric illness or condition which could interfere with their ability to understand the requirements of the study.
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0004936 (UMLS CUI [1,3])