Diabetes Mellitus, Insulin-Dependent
Item
t1dm for at least 5 years as defined by the following:
boolean
C0011854 (UMLS CUI [1])
Insulin Dependence | Insulin Quantity Requirement
Item
1. insulin dependence (with an insulin requirement less than 0.8 units/kg/day).
boolean
C0021641 (UMLS CUI [1,1])
C0439857 (UMLS CUI [1,2])
C0021641 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1514873 (UMLS CUI [2,3])
islet cell antibody | Insulin Antibodies | Insulin regime | islet cell antibody | IA-2 (Protein Tyrosine Phosphatase Antibody) | Anti-GAD antibody
Item
2. current or past anti-islet antibodies (anti-insulin before initiation of insulin therapy, anti-islet cell (ica), anti-tyrosine phosphatase ia-2, and/or anti-glutamic acid decarboxylase (gad65) antibodies).
boolean
C0063900 (UMLS CUI [1])
C0021644 (UMLS CUI [2])
C0557978 (UMLS CUI [3])
C0063900 (UMLS CUI [4])
C1139665 (UMLS CUI [5])
C1167897 (UMLS CUI [6])
Body mass index
Item
3. bmi greater than or equal to 20 kg/m(2) and less than or equal to 30 kg/m(2).
boolean
C1305855 (UMLS CUI [1])
C-Peptide | C-peptide stimulation test Arginine
Item
c-peptide greater than or equal to 0.3 and less than or equal to 1.2 ng/ml at baseline or during an arginine-stimulated c-peptide test.
boolean
C0006558 (UMLS CUI [1])
C0430183 (UMLS CUI [2,1])
C0003765 (UMLS CUI [2,2])
Age
Item
age 18 to 60 years, inclusive.
boolean
C0001779 (UMLS CUI [1])
Gastroparesis Symptomatic
Item
symptomatic gastroparesis.
boolean
C0152020 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
Diabetic Nephropathy | Creatinine clearance measurement | 24 hour urine albumin output measurement
Item
diabetic nephropathy with a creatinine clearance less than 60 cc/min or 24-hour urine albumin greater than 300 mg.
boolean
C0011881 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
C1278236 (UMLS CUI [3])
Insulin Quantity Requirement
Item
insulin requirements greater than 0.8 units/kg/day.
boolean
C0021641 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
Loss of hypoglycemic warning | Diabetes Therapy Modification | Episode Quantity Hypoglycemia Severe | Assistance Patient need for | Hospitalization Due to Hypoglycemia
Item
hypoglycemia unawareness: unless easily corrected via simple modifications in the patient's diabetes regimen, the potential enrollee will be excluded if he/she has suffered greater than or equal to 2 episodes of severe hypoglycemia during the most recent 12 months, defined as requiring assistance from a third party, receiving assistance from medics, visiting an er or being hospitalized due to the hypoglycemia.
boolean
C0342317 (UMLS CUI [1])
C3274787 (UMLS CUI [2,1])
C0392747 (UMLS CUI [2,2])
C0332189 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0020615 (UMLS CUI [3,3])
C0205082 (UMLS CUI [3,4])
C1269765 (UMLS CUI [4,1])
C0686904 (UMLS CUI [4,2])
C0019993 (UMLS CUI [5,1])
C0678226 (UMLS CUI [5,2])
C0020615 (UMLS CUI [5,3])
Chronic infectious disease Evidence of
Item
evidence of chronic infection.
boolean
C0151317 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
Malignant Neoplasms
Item
history of any malignancy.
boolean
C0006826 (UMLS CUI [1])
Medical condition chronic High risk Patient
Item
any chronic medical condition that unduly increase risk for the potential enrollee as judged by study investigators.
boolean
C3843040 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0332167 (UMLS CUI [1,3])
C0030705 (UMLS CUI [1,4])
Abnormality of blood and blood-forming tissues
Item
hematologic abnormalities:
boolean
C0850715 (UMLS CUI [1])
Anemia | Hematocrit level | Gender
Item
1. anemia (hematocrit less than 31.8% in women and less than 36.7% in men).
boolean
C0002871 (UMLS CUI [1])
C0518014 (UMLS CUI [2])
C0079399 (UMLS CUI [3])
Leukopenia | White Blood Cell Count
Item
2. leukopenia (wbc count less than 3.4 k/mm(3)).
boolean
C0023530 (UMLS CUI [1])
C0023508 (UMLS CUI [2])
Thrombocytopenia | Platelet Count measurement
Item
3. thrombocytopenia (platelet count less than 162 k/mm(3)).
boolean
C0040034 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
hypertension untreated | HYPERTENSION, RESISTANT TO CONVENTIONAL THERAPY | Blood Pressure
Item
hypertension, whether untreated or resistant to medical treatment, with blood pressure greater than 140/85 mm hg.
boolean
C0745134 (UMLS CUI [1])
C1834155 (UMLS CUI [2])
C0005823 (UMLS CUI [3])
Pregnancy | Breast Feeding | Pregnancy, Planned
Item
pregnancy, breastfeeding or planned pregnancy within two years.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
Compliance behavior Limited
Item
unable to identify primary care provider willing to partner with study investigators.
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])