Healthy Volunteers
Item
healthy volunteers
boolean
C1708335 (UMLS CUI [1])
Handedness | Age | Mental disorders Major | Mood Disorders First Degree Relative | Hamilton rating scale for depression | Gender | Education
Item
right-handed subjects (ages 18-50) will be selected who have not met criteria for any major psychiatric disorder, have no known first-degree relatives with mood disorders, and have a current score on the hamilton depression rating scale (hdrs; 17 item) in the not depressed range ( 7). control subjects will be matched to depressed subjects and their relatives for age, gender, and education.
boolean
C0023114 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0004936 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
C0525045 (UMLS CUI [4,1])
C1517194 (UMLS CUI [4,2])
C0451203 (UMLS CUI [5])
C0079399 (UMLS CUI [6])
C0013622 (UMLS CUI [7])
Major Depressive Disorder Volunteer Sample
Item
mdd samples
boolean
C1269683 (UMLS CUI [1,1])
C0150095 (UMLS CUI [1,2])
Handedness | Age | Major Depressive Disorder
Item
right-handed subjects (ages 18-50) will be selected with a past history of mdd by dsm-iv criteria.
boolean
C0023114 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C1269683 (UMLS CUI [3])
Relative Healthy
Item
healthy relatives
boolean
C0080103 (UMLS CUI [1,1])
C3898900 (UMLS CUI [1,2])
Healthy Volunteers | Handedness | First Degree Relative | Major Depressive Disorder
Item
healthy, right-handed, first-degree relatives of patients with mdd will be recruited.
boolean
C1708335 (UMLS CUI [1])
C0023114 (UMLS CUI [2])
C1517194 (UMLS CUI [3])
C1269683 (UMLS CUI [4])
Antidepressive Agents | Fluoxetine | fMRI | Pharmaceutical Preparations Changing monoamine Neurochemistry | Pharmaceutical Preparations Changing Function Cerebrovascular | Pharmaceutical Preparations Changing cardiovascular function | Imaging | Pharmaceutical Preparations Effective Discontinue
Item
subjects must not have taken antidepressant drugs for at least 3 months (4 months for fluoxetine) prior to the fmri studies or other medications likely to alter monoamine neurochemistry or cerebrovascular and cardiovascular function for at least 3 weeks prior to imaging. however, effective medications will not be discontinued for the purposes of this study. subjects will also be excluded if they have:
boolean
C0003289 (UMLS CUI [1])
C0016365 (UMLS CUI [2])
C0376335 (UMLS CUI [3])
C0013227 (UMLS CUI [4,1])
C0392747 (UMLS CUI [4,2])
C0599682 (UMLS CUI [4,3])
C0699841 (UMLS CUI [4,4])
C0013227 (UMLS CUI [5,1])
C0392747 (UMLS CUI [5,2])
C0031843 (UMLS CUI [5,3])
C1880018 (UMLS CUI [5,4])
C0013227 (UMLS CUI [6,1])
C0392747 (UMLS CUI [6,2])
C0007227 (UMLS CUI [6,3])
C0011923 (UMLS CUI [7])
C0013227 (UMLS CUI [8,1])
C1280519 (UMLS CUI [8,2])
C1444662 (UMLS CUI [8,3])
Psychotic Disorders
Item
1. psychosis
boolean
C0033975 (UMLS CUI [1])
Illness Affecting physiology | Illness Affecting Anatomy | nervous system disorder Affecting physiology | nervous system disorder Affecting Anatomy | Hypertensive disease | Cardiovascular Diseases
Item
2. medical or neurological illnesses likely to affect physiology or anatomy, i.e. hypertension, cardiovascular disorders
boolean
C0221423 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0031843 (UMLS CUI [1,3])
C0221423 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C1384516 (UMLS CUI [2,3])
C0027765 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C0031843 (UMLS CUI [3,3])
C0027765 (UMLS CUI [4,1])
C0392760 (UMLS CUI [4,2])
C1384516 (UMLS CUI [4,3])
C0020538 (UMLS CUI [5])
C0007222 (UMLS CUI [6])
Drug abuse | Benzodiazepines | Drug Dependence Lifetime
Item
3. a history of drug (including benzodiazepines (bzd)) abuse within 1 year or a lifetime history of drug dependence (dsm iv criteria)
boolean
C0013146 (UMLS CUI [1])
C0005064 (UMLS CUI [2])
C1510472 (UMLS CUI [3,1])
C4071830 (UMLS CUI [3,2])
Alcohol abuse | Alcohol dependence Lifetime
Item
4. a history of alcohol abuse within 1 year or a lifetime history of alcohol dependence (dsm iv criteria)
boolean
C0085762 (UMLS CUI [1])
C0001973 (UMLS CUI [2,1])
C4071830 (UMLS CUI [2,2])
Pregnancy Pregnancy Test
Item
5. current pregnancy (as documented by pregnancy testing at screening or at days of the challenge studies)
boolean
C0032961 (UMLS CUI [1,1])
C0032976 (UMLS CUI [1,2])
Breast Feeding
Item
6. current breast feeding
boolean
C0006147 (UMLS CUI [1])
Smoker
Item
7. are smokers
boolean
C0337664 (UMLS CUI [1])
Feeling suicidal Serious | Suicidal behavior Serious | Low Risk Depressive Symptoms transient | Amino Acids Mixture | Suicide attempt Severity | Thoughts of self harm | Suicide attempt Planned | Planning suicide
Item
8. serious suicidal ideation or behavior. in this study, there is a small risk of transient depressive symptoms occurring after ingesting the amino acid mixture. therefore, if volunteers manifest evidence of serious suicidal ideation or behavior, they will be excluded from participating. criteria for meeting suicidal ideation include but are not limited to: 1) thoughts of suicide within the past 3 months which are accompanied by intent to harm oneself, serious consideration of means or plan to attempt suicide, evidence of arranging for a suicide attempt (e.g. giving away prized possessions or updating a will), or clear desire to commit suicide, 2) severity of past suicide events, if applicable or 3) a current plan for harming themselves. all assessments will be conducted by an experienced, nimh credentialed health professional, such as a psychiatrist or psychiatric nurse who will use their expert knowledge and experiences in determining the authenticity of a participant s information and handle the situation accordingly.
boolean
C0424000 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C1760428 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C3538919 (UMLS CUI [3,1])
C0086132 (UMLS CUI [3,2])
C0205374 (UMLS CUI [3,3])
C0002520 (UMLS CUI [4,1])
C0439962 (UMLS CUI [4,2])
C0038663 (UMLS CUI [5,1])
C0439793 (UMLS CUI [5,2])
C0522178 (UMLS CUI [6])
C0038663 (UMLS CUI [7,1])
C1301732 (UMLS CUI [7,2])
C0424001 (UMLS CUI [8])
Exclusion Criteria MRI General
Item
9. general mri exclusion criteria
boolean
C0680251 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0205246 (UMLS CUI [1,3])
Alcohol consumption | Alcohol consumption Moderate | Benzodiazepines Use Regular | Alcohol intake above recommended sensible limits | Gender | Drug usage Interferes with research results | Smoker | Nicotine Interaction Depressive disorder | Withdrawal Symptoms | behavioral response to nicotine | Tobacco Dependence Response neural
Item
subjects must exhibit no or only moderate alcohol use. subjects with current or previous regular use (greater than 4 weeks) of bzds and excessive use of alcohol (greater than 8 ounces/day for men and greater than 6 ounces/day for women) in the past or present are ineligible for participation, as such drug use may confound the results. smokers (regular use within the last 3 months) are ineligible because of the evidence for interactions between nicotine and depression, and the possibility of withdrawal symptoms that may affect behavioral and neural responses to td.
boolean
C0001948 (UMLS CUI [1])
C0001948 (UMLS CUI [2,1])
C0205081 (UMLS CUI [2,2])
C0005064 (UMLS CUI [3,1])
C1524063 (UMLS CUI [3,2])
C0205272 (UMLS CUI [3,3])
C0560219 (UMLS CUI [4])
C0079399 (UMLS CUI [5])
C0242510 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C0683954 (UMLS CUI [6,3])
C0337664 (UMLS CUI [7])
C0028040 (UMLS CUI [8,1])
C1704675 (UMLS CUI [8,2])
C0011581 (UMLS CUI [8,3])
C0087169 (UMLS CUI [9])
C1325839 (UMLS CUI [10])
C0040332 (UMLS CUI [11,1])
C0871261 (UMLS CUI [11,2])
C3714606 (UMLS CUI [11,3])
Age | Heterogeneity biological | Major Depressive Disorder criteria | Magnetic Resonance Imaging | Cerebrovascular Disorders | Single major depressive episode | medical condition | Mental disorders | Functional Imaging | Major Depressive Disorder Primary
Item
subjects beyond age 50 are excluded to address the biological heterogeneity encompassed by the mdd criteria, since depressives whose age-at-onset is later than 50 have a far greater likelihood of having mri correlates of cerebrovascular disease than age-matched healthy controls or age-matched early-onset depressives. subjects whose first major depressive episodes arose temporally after other medical or psychiatric conditions will also be excluded, since their functional imaging results generally differ from those reported in primary mdd.
boolean
C0001779 (UMLS CUI [1])
C0019409 (UMLS CUI [2,1])
C0205460 (UMLS CUI [2,2])
C1269683 (UMLS CUI [3,1])
C0243161 (UMLS CUI [3,2])
C0024485 (UMLS CUI [4])
C0007820 (UMLS CUI [5])
C0024517 (UMLS CUI [6])
C3843040 (UMLS CUI [7])
C0004936 (UMLS CUI [8])
C1517324 (UMLS CUI [9])
C1269683 (UMLS CUI [10,1])
C0205225 (UMLS CUI [10,2])