COLON ADENOCARCINOMA METASTATIC | Adenocarcinoma of rectum metastatic | Measurable Disease | Neoplasm Metastasis Site Evidence of | Imaging | Markers
Item
histologically confirmed metastatic adenocarcinoma of the colon or rectum, with measurable disease. the primary histologic diagnosis is sufficient if there is clear evidence by imaging and/or markers of metastatic disease sites.
boolean
C0742581 (UMLS CUI [1])
C0149978 (UMLS CUI [2,1])
C1522484 (UMLS CUI [2,2])
C1513041 (UMLS CUI [3])
C0027627 (UMLS CUI [4,1])
C1515974 (UMLS CUI [4,2])
C0332120 (UMLS CUI [4,3])
C0011923 (UMLS CUI [5])
C2745888 (UMLS CUI [6])
Therapeutic procedure Irinotecan hydrochloride Based failed | Therapeutic procedure oxaliplatin Based failed
Item
patients must have failed cpt-11 and oxaliplatin based therapies.
boolean
C0087111 (UMLS CUI [1,1])
C0594375 (UMLS CUI [1,2])
C1705938 (UMLS CUI [1,3])
C0231175 (UMLS CUI [1,4])
C0087111 (UMLS CUI [2,1])
C0069717 (UMLS CUI [2,2])
C1705938 (UMLS CUI [2,3])
C0231175 (UMLS CUI [2,4])
Prior Chemotherapy Quantity advanced disease
Item
patients must have received at least two prior chemotherapy regimens for advanced disease (completed > 4 weeks prior to enrollment).
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0679246 (UMLS CUI [1,3])
Malignant Neoplasm Amenable Biopsy | Paraffin Embedded Tissue Available
Item
tumor must be accessible for biopsy or paraffin embedded tissue must be available for review.
boolean
C0006826 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C0005558 (UMLS CUI [1,3])
C1519524 (UMLS CUI [2,1])
C0470187 (UMLS CUI [2,2])
SWOG performance status
Item
swog performance status 0-2.
boolean
C1519429 (UMLS CUI [1,1])
C1518965 (UMLS CUI [1,2])
Absolute neutrophil count | Blood Platelets
Item
agc >1000, platelets >100,000.
boolean
C0948762 (UMLS CUI [1])
C0005821 (UMLS CUI [2])
Bilirubin, total measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Secondary malignant neoplasm of liver
Item
total bilirubin < 3 x upper limit of normal. transaminase (ast and/or alt) < 2 x upper limit of normal or < 5 x upper limit of normal in patients with liver metastasis.
boolean
C0201913 (UMLS CUI [1])
C0201899 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C0494165 (UMLS CUI [4])
Creatinine clearance measurement | Estimation of creatinine clearance by Cockcroft-Gault formula
Item
patients must have a measured or calculated creatinine clearance greater than 35 ml/min obtained within 28 days prior to registration.
boolean
C0373595 (UMLS CUI [1])
C2711451 (UMLS CUI [2])
Age
Item
age greater than or equal to 18 years
boolean
C0001779 (UMLS CUI [1])
Hemoglobin | Blood Transfusion
Item
patients should have hemoglobin > 9 g/dl; patients may be transfused to achieve this level of hemoglobin.
boolean
C0019046 (UMLS CUI [1])
C0005841 (UMLS CUI [2])
Abnormality Related to Cancer | medical condition Major Pre-existing | medical condition Major Unstable
Item
except for cancer-related abnormalities, patients should not have unstable or pre-existing major medical conditions.
boolean
C1704258 (UMLS CUI [1,1])
C2826292 (UMLS CUI [1,2])
C3843040 (UMLS CUI [2,1])
C0205164 (UMLS CUI [2,2])
C2347662 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
C0443343 (UMLS CUI [3,3])
Malignant Neoplasms | Colon Carcinoma | Rectal Carcinoma | Basal cell carcinoma Treated Adequate | Squamous cell carcinoma of skin | Carcinoma in situ of uterine cervix | Malignant Neoplasm Free of
Item
history of a malignancy other than colon or rectal cancer, except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for five years.
boolean
C0006826 (UMLS CUI [1])
C0699790 (UMLS CUI [2])
C0007113 (UMLS CUI [3])
C0007117 (UMLS CUI [4,1])
C1522326 (UMLS CUI [4,2])
C0205411 (UMLS CUI [4,3])
C0553723 (UMLS CUI [5])
C0851140 (UMLS CUI [6])
C0006826 (UMLS CUI [7,1])
C0332296 (UMLS CUI [7,2])
Metastatic malignant neoplasm to brain
Item
patients with brain metastasis.
boolean
C0220650 (UMLS CUI [1])
Myocardial Infarction | Congestive heart failure Evidence of
Item
history of recent (within one year) myocardial infarction or evidence of congestive heart failure.
boolean
C0027051 (UMLS CUI [1])
C0018802 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])
Condition Preventing Follow-up | Condition Preventing Protocol Compliance
Item
patients that have psychological, familial, sociological, or geographical conditions that do not permit medical follow-up and compliance with the study protocol.
boolean
C0348080 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C3274571 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
Malignant Neoplasms Complication Life Threatening Immediate
Item
patients should not have any immediate life-threatening complications of their malignancies.
boolean
C0006826 (UMLS CUI [1,1])
C0009566 (UMLS CUI [1,2])
C2826244 (UMLS CUI [1,3])
C0205253 (UMLS CUI [1,4])