Philadelphia chromosome positive chronic myelogenous leukemia | Chronic myeloid leukemia, BCR/ABL-positive | Leukemia, Myeloid, Accelerated Phase | Resistance Hematologic Primary Imatinib mesylate | Resistance Hematologic Acquired Imatinib mesylate | intolerance to Imatinib mesylate
Item
subjects with philadelphia chromosome positive (ph+) or the fused gene bcr/abl positive (bcr/abl+) accelerated phase chronic myeloid leukemia (cml) whose disease has primary or acquired hematologic resistance to imatinib mesylate or who are intolerant of imatinib mesylate.
boolean
C0279543 (UMLS CUI [1])
C2861580 (UMLS CUI [2])
C0023472 (UMLS CUI [3])
C1514892 (UMLS CUI [4,1])
C0205488 (UMLS CUI [4,2])
C0205225 (UMLS CUI [4,3])
C0939537 (UMLS CUI [4,4])
C1514892 (UMLS CUI [5,1])
C0205488 (UMLS CUI [5,2])
C0439661 (UMLS CUI [5,3])
C0939537 (UMLS CUI [5,4])
C1744706 (UMLS CUI [6,1])
C0939537 (UMLS CUI [6,2])
imatinib; Exposure to | Imatinib mesylate | Therapeutic procedure Chronic Myeloid Leukemia
Item
subjects must have had prior exposure to imatinib. however, imatinib mesylate does not need to be their most recent cml treatment prior to coming on this study.
boolean
C0935989 (UMLS CUI [1,1])
C0332157 (UMLS CUI [1,2])
C0939537 (UMLS CUI [2])
C0087111 (UMLS CUI [3,1])
C0023473 (UMLS CUI [3,2])
Age
Item
men and women, 18 years of age or older.
boolean
C0001779 (UMLS CUI [1])
Liver function
Item
adequate hepatic function.
boolean
C0232741 (UMLS CUI [1])
Renal function
Item
adequate renal function.
boolean
C0232804 (UMLS CUI [1])
Childbearing Potential Contraceptive methods | Low risk pregnancy
Item
women of childbearing potential (wocbp) must be using an adequate method of contraception to avoid pregnancy throughout the study and for a period of least 1 month before and at least 3 months after the study in such a manner that the risk of pregnancy is minimized.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0404841 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
women who are pregnant or breastfeeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Transplantation Suitable Willing
Item
subjects who are eligible and willing to undergo transplantation during the screening period.
boolean
C0040732 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C0600109 (UMLS CUI [1,3])
Disease Uncontrolled Serious Impairing Protocol Compliance
Item
a serious uncontrolled medical disorder or active infection that would impair the ability of the subjects to receive protocol therapy.
boolean
C0012634 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C0221099 (UMLS CUI [1,4])
C0525058 (UMLS CUI [1,5])
Cardiovascular Disease Uncontrolled | Cardiovascular Disease Significant
Item
uncontrolled or significant cardiovascular disease.
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
Pharmaceutical Preparations Bleeding Risk Increase
Item
medications that increase bleeding risk.
boolean
C0013227 (UMLS CUI [1,1])
C3251812 (UMLS CUI [1,2])
C0442805 (UMLS CUI [1,3])
Pharmaceutical Preparations Changing Cardiac rhythms
Item
medications that change heart rhythms.
boolean
C0013227 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
C0232187 (UMLS CUI [1,3])
Dementia Preventing Informed Consent | Abnormal mental state Preventing Informed Consent
Item
dementia or altered mental status that would prohibit the understanding or rendering of informed consent.
boolean
C0497327 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C0278061 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0021430 (UMLS CUI [2,3])
Blood Coagulation Disorders Significant Independent of Chronic Myeloid Leukemia
Item
history of significant bleeding disorder unrelated to cml.
boolean
C0005779 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0332291 (UMLS CUI [1,3])
C0023473 (UMLS CUI [1,4])
Malignant Neoplasm incurable | Myeloid Leukemia, Chronic
Item
concurrent incurable malignancy other than cml.
boolean
C0006826 (UMLS CUI [1,1])
C0175969 (UMLS CUI [1,2])
C0023473 (UMLS CUI [2])
organ dysfunction Evidence Preventing Protocol Compliance | Digestive organ Dysfunction Preventing Protocol Compliance
Item
evidence of organ dysfunction or digestive dysfunction that would prevent administration of study therapy.
boolean
C0349410 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C1292733 (UMLS CUI [1,3])
C0525058 (UMLS CUI [1,4])
C0227435 (UMLS CUI [2,1])
C3887504 (UMLS CUI [2,2])
C1292733 (UMLS CUI [2,3])
C0525058 (UMLS CUI [2,4])
dasatinib | BMS 354825
Item
prior therapy with dasatinib (bms-354825).
boolean
C1455147 (UMLS CUI [1])
C1328005 (UMLS CUI [2])
Prisoners | In prison Involuntary Therapeutic procedure Mental disorders | In prison Involuntary Therapeutic procedure physical illness | In prison Involuntary Therapeutic procedure Communicable Diseases
Item
prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious disease) illness must not be enrolled into this study.
boolean
C0033167 (UMLS CUI [1])
C0392751 (UMLS CUI [2,1])
C2986385 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
C0004936 (UMLS CUI [2,4])
C0392751 (UMLS CUI [3,1])
C2986385 (UMLS CUI [3,2])
C0087111 (UMLS CUI [3,3])
C0683323 (UMLS CUI [3,4])
C0392751 (UMLS CUI [4,1])
C2986385 (UMLS CUI [4,2])
C0087111 (UMLS CUI [4,3])
C0009450 (UMLS CUI [4,4])