Squamous cell carcinoma of the head and neck
Item
histologically or cytologically proven squamous cell carcinoma of the head & neck.
boolean
C1168401 (UMLS CUI [1])
Age
Item
age greater than or equal to 18.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status of 0 to 1
boolean
C1520224 (UMLS CUI [1])
malignant disease Measurable
Item
measurable malignant disease.
boolean
C0442867 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
Regimen Platinum-Based failed | Prior Therapy Quantity | curative treatment
Item
patients that have failed at least one platinum-containing regimen and have received no more than three prior regimens and do not have other curative treatment options.
boolean
C0040808 (UMLS CUI [1,1])
C1514162 (UMLS CUI [1,2])
C0231175 (UMLS CUI [1,3])
C1514463 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1273390 (UMLS CUI [3])
Operative Surgical Procedure Status post | Therapeutic radiology procedure Status post
Item
patients must be at least 2 wks post surgery or radiation therapy
boolean
C0543467 (UMLS CUI [1,1])
C0231290 (UMLS CUI [1,2])
C1522449 (UMLS CUI [2,1])
C0231290 (UMLS CUI [2,2])
Chemotherapy Status post
Item
patients must be at least 4 weeks post chemotherapy
boolean
C0392920 (UMLS CUI [1,1])
C0231290 (UMLS CUI [1,2])
Study Protocol Laboratory Results Fulfill
Item
meets protocol requirements for specified laboratory values.
boolean
C2348563 (UMLS CUI [1,1])
C1254595 (UMLS CUI [1,2])
C1550543 (UMLS CUI [1,3])
Informed Consent | Compliance behavior
Item
written informed consent and cooperation of patient.
boolean
C0021430 (UMLS CUI [1])
C1321605 (UMLS CUI [2])
Childbearing Potential Contraceptive methods
Item
appropriate use of effective contraception if of childbearing potential.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Investigational New Drugs
Item
no investigational drugs of any type within 30 days prior to administration.
boolean
C0013230 (UMLS CUI [1])
Farnesyl Transferase Inhibitor Exposure to
Item
prior exposure to farnesyl transferase inhibitors
boolean
C1517132 (UMLS CUI [1,1])
C0332157 (UMLS CUI [1,2])
medical condition Interferes with oral medication Intake
Item
medical conditions that would interfere with taking oral medications.
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0175795 (UMLS CUI [1,3])
C1512806 (UMLS CUI [1,4])
QTc Prolongation Significant
Item
patients with significant qtc prolongation at baseline (>500 msec.)
boolean
C0855333 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnant or nursing women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
HIV Seropositivity | AIDS related illness
Item
known hiv positivity or aids-related illness.
boolean
C0019699 (UMLS CUI [1])
C0740842 (UMLS CUI [2])
Chemotherapy | Hormone Therapy | Therapeutic radiology procedure | Immunotherapy
Item
concomitant chemotherapy, hormonal therapy, radiotherapy or immunotherapy
boolean
C0392920 (UMLS CUI [1])
C0279025 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
C0021083 (UMLS CUI [4])
signs Involvement with Dura Mater | signs Involvement with Meninges | signs Involvement with Brain
Item
patients with any signs of involvement of the dura, meninges, or brain.
boolean
C0220912 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C0013313 (UMLS CUI [1,3])
C0220912 (UMLS CUI [2,1])
C1314939 (UMLS CUI [2,2])
C0025285 (UMLS CUI [2,3])
C0220912 (UMLS CUI [3,1])
C1314939 (UMLS CUI [3,2])
C0006104 (UMLS CUI [3,3])
Squamous cell carcinoma of nasopharynx
Item
patients with squamous cell carcinoma of the nasopharynx
boolean
C0279698 (UMLS CUI [1])
Malignant Neoplasms | cancer treatment
Item
patients who currently have other cancers or have been treated in the last 5 years for any other malignancy.
boolean
C0006826 (UMLS CUI [1])
C0920425 (UMLS CUI [2])