Chronic kidney disease
Item
chronic kidney disease
boolean
C1561643 (UMLS CUI [1])
Stable proteinuria
Item
stable proteinuria above 300 mg/24 hours (no variations above 25% in the last 6 months)
boolean
C0033687 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Renal function
Item
normal or slightly impaired stable renal function defined as serum creatinine level below 1.7 mg/dl (egfr > 45 ml/min)
boolean
C0201976 (UMLS CUI [1,1])
C3811844 (UMLS CUI [1,2])
Nephrotic syndrome
Item
nephrotic syndrome
boolean
C0027726 (UMLS CUI [1])
Immunosuppression
Item
steroids or other immunosuppressive treatment minimum during six months before the study
boolean
C0021079 (UMLS CUI [1])
Diabetes mellitus
Item
diabetes mellitus
boolean
C0011849 (UMLS CUI [1])
Serum Potassium
Item
potassium serum level > 5.1 meq/l
boolean
C0302353 (UMLS CUI [1])
Serum albumin
Item
albumin serum level < 2.0mg/dl
boolean
C0523465 (UMLS CUI [1])
Serum creatinine
Item
creatinine serum level >2 mg/dl
boolean
C0201976 (UMLS CUI [1])
NYHA
Item
current diagnosis of heart failure new york heart association (nyha) class ii-iv
boolean
C1275491 (UMLS CUI [1])
Heart valve disease or second or third degree heart block without a pacemaker
Item
clinically significant valvular heart disease or second or third degree heart block without a pacemaker
boolean
C0018824 (UMLS CUI [1])
C0004245 (UMLS CUI [2,1])
C0030163 (UMLS CUI [2,2])
history of hypertensive encephalopathy, cerebrovascular accident or transient ischemic cerebral attack
Item
history of hypertensive encephalopathy, cerebrovascular accident or transient ischemic cerebral attack
boolean
C0151620 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0007787 (UMLS CUI [3])
history of myocardial infarction, unstable angina pectoris, coronary bypass surgery, or any percutaneous coronary intervention
Item
history of myocardial infarction, unstable angina pectoris, coronary bypass surgery, or any percutaneous coronary intervention
boolean
C0027051 (UMLS CUI [1])
C0002965 (UMLS CUI [2])
C0010055 (UMLS CUI [3])
C1532338 (UMLS CUI [4])
history of malignancy
Item
history of malignancy including leukemia and lymphoma (but not basal cell skin carcinoma) within the past five years
boolean
C0006826 (UMLS CUI [1])
pregnant or breastfeeding
Item
pregnant or nursing women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Other surgical or medical condition
Item
any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of study drugs.
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
Alcohol abuse
Item
history of alcohol abuse
boolean
C0038586 (UMLS CUI [1])
NSAID abuse
Item
nsaid abuse (more than 2 doses per week)
boolean
C0581388 (UMLS CUI [1])
contraindications to the study medications, including history of allergy to ace inhibitors, at-1 receptor blockers and aldosterone antagonists
Item
known or suspected contraindications to the study medications, including history of allergy to ace inhibitors, at-1 receptor blockers and aldosterone antagonists
boolean
C0020517 (UMLS CUI [1,1])
C0003015 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0521942 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0002007 (UMLS CUI [3,2])