Locally advanced breast cancer Amenable Operative Surgical Procedures | Carcinoma breast stage IV Amenable Operative Surgical Procedures | Locally advanced breast cancer Amenable Therapeutic radiology procedure Curative | Carcinoma breast stage IV Amenable Therapeutic radiology procedure Curative
Item
locally advanced or metastatic breast cancer not amenable to surgery or radiation with curative intent
boolean
C3495949 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C0543467 (UMLS CUI [1,3])
C0278488 (UMLS CUI [2,1])
C3900053 (UMLS CUI [2,2])
C0543467 (UMLS CUI [2,3])
C3495949 (UMLS CUI [3,1])
C3900053 (UMLS CUI [3,2])
C1522449 (UMLS CUI [3,3])
C1276305 (UMLS CUI [3,4])
C0278488 (UMLS CUI [4,1])
C3900053 (UMLS CUI [4,2])
C1522449 (UMLS CUI [4,3])
C1276305 (UMLS CUI [4,4])
Prior Chemotherapy
Item
must have received any chemotherapy regimen in the past
boolean
C1514457 (UMLS CUI [1])
Chemotherapy Refractory cancer Evidence of | Disease Progression Status post Prior Chemotherapy Advanced cancer
Item
evidence of tumor resistance to last chemotherapy defined as progression after 6 months of previous chemotherapy for advanced disease
boolean
C0392920 (UMLS CUI [1,1])
C0677936 (UMLS CUI [1,2])
C0332120 (UMLS CUI [1,3])
C0242656 (UMLS CUI [2,1])
C0231290 (UMLS CUI [2,2])
C1514457 (UMLS CUI [2,3])
C0877373 (UMLS CUI [2,4])
Measurable Disease Imaging Techniques
Item
must have measurable (by imaging techniques) disease
boolean
C1513041 (UMLS CUI [1,1])
C0079595 (UMLS CUI [1,2])
Bone Marrow function | Liver function | Renal function
Item
adequate bone marrow, liver and renal function
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
Informed Consent | Compliance behavior Study Protocol
Item
must provide evidence of informed consent and willingness and ability to comply with scheduled visits, treatment plan and study procedures.
boolean
C0021430 (UMLS CUI [1])
C1321605 (UMLS CUI [2,1])
C2348563 (UMLS CUI [2,2])
Prior Chemotherapy Quantity Carcinoma breast stage IV
Item
received more than 2 prior chemotherapy regimens for metastatic disease
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0278488 (UMLS CUI [1,3])
Pharmaceutical Preparation Class of Trial Agent Same | Topoisomerase I Inhibitors
Item
received in the past another drug of the same class as the investigational drug, i.e. topoisomerase i inhibitor
boolean
C0013227 (UMLS CUI [1,1])
C2983595 (UMLS CUI [1,2])
C0445247 (UMLS CUI [1,3])
C0594374 (UMLS CUI [2])
Study Subject Participation Status
Item
enrolled in another clinical intervention study
boolean
C2348568 (UMLS CUI [1])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Refused
Item
pregnancy, breast feeding, fertile women refusing to use reliable contraceptive methods
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C1705116 (UMLS CUI [3,3])
cardiac event | Thrombotic disorder
Item
cardiac or thrombotic event in the last 12 months
boolean
C0741923 (UMLS CUI [1])
C0040053 (UMLS CUI [2])
Metastatic malignant neoplasm to brain
Item
brain metastases
boolean
C0220650 (UMLS CUI [1])