diagnosis of b-cell lymphoma or waldenstroms cll
Item
diagnosis of b-cell lymphoma, waldenstrom's cll with surface expression of both cd20 and 1d10 antigen by immunohistochemistry (ihc) or fluorescence of activated cell sorting (facs) with anti-cd20 and 1d10 antibody. positive 1d10 expression in a facs assay is defined as more than 2 times the mean fluorescence intensity (mfi) of the control antibody by facs or greater than 20% of cells 1d10+ by ihc.
boolean
C0079731 (UMLS CUI [1])
C0024419 (UMLS CUI [2])
confirmation of diagnosis
Item
confirmation of diagnosis in laboratory of pathology, nci or osu.
boolean
C0011911 (UMLS CUI [1])
C0348026 (UMLS CUI [2,1])
C1513882 (UMLS CUI [2,2])
prior therapy with systemic agents or rituximab
Item
prior therapy with at least one systemic treatment, and not a candidate for potentially curative (i.e., transplant) treatment at the time of study entry. prior treatment with rituximab greater than or equal to 1 month ago is permitted.
boolean
C1514463 (UMLS CUI [1,1])
C1515119 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C4047978 (UMLS CUI [2,2])
age
Item
age greater than 18 years.
boolean
C0001779 (UMLS CUI [1])
ecog performance status
Item
ecog performance status less than or equal to 2.
boolean
C1632812 (UMLS CUI [1])
organ function parameters
Item
major organ function: anc greater than or equal to 500/microliter, platelet greater than or equal 25,000/microliter, creatinine less than or equal to 1.5 mg/dl or creatinine clearance greater than 60 cc/min; sgpt less than 5 x upper limit of normal; bilirubin less than 2 mg/dl (total) except less than 5 mg/dl in patients with gilbert's syndrome as defined by greater than 80% unconjugated; unless impairment due to organ involvement by lymphoma.
boolean
C0948762 (UMLS CUI [1])
C0005821 (UMLS CUI [2])
C0201976 (UMLS CUI [3])
C0373595 (UMLS CUI [4])
C0201836 (UMLS CUI [5])
C1278039 (UMLS CUI [6])
informed consent
Item
provides informed consent.
boolean
C0021430 (UMLS CUI [1])
pregnant or nursing, willing to use contraception
Item
pregnancy or nursing. both male and female patients must be willing to use adequate contraception.
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])
C0700589 (UMLS CUI [1,3])
prior apolizumab treatment
Item
prior apolizumab treatment.
boolean
C1514463 (UMLS CUI [1,1])
C1122758 (UMLS CUI [1,2])
cardiac, cerebrovascular or peripheral vascular disease
Item
sactive cardiac disease, cerebrovascular disease or peripheral arterial vascular disease.
boolean
C0007222 (UMLS CUI [1,1])
C0007820 (UMLS CUI [1,2])
C3841707 (UMLS CUI [1,3])
active cns lymphoma
Item
active cns lymphoma.
boolean
C0742472 (UMLS CUI [1])
chemotherapy or systemic steroid therapy
Item
systemic cytotoxic chemotherapy within 3 weeks of enrollment or systemic steroids (except stable doses less than 10 mg/day) within 1 week of enrollment.
boolean
C0392920 (UMLS CUI [1])
C0149783 (UMLS CUI [2])