Adult | Philadelphia chromosome-negative precursor B-cell acute lymphoblastic leukemia
Item
adult subjects with philadelphia-negative b-precursor all, with any of the following:
boolean
C0001675 (UMLS CUI [1])
C4075283 (UMLS CUI [2])
Relapsed | Refractory | First line treatment | Disease remission First | Duration
Item
relapsed or refractory after first line therapy with first remission duration
boolean
C0205336 (UMLS CUI [1])
C0205269 (UMLS CUI [2])
C1708063 (UMLS CUI [3])
C0544452 (UMLS CUI [4,1])
C0205435 (UMLS CUI [4,2])
C0449238 (UMLS CUI [5])
month
Item
≤ 12 months; or
boolean
C0439231 (UMLS CUI [1])
Relapsed | Refractory | Salvage Therapy First
Item
relapsed or refractory after first salvage therapy; or
boolean
C0205336 (UMLS CUI [1])
C0205269 (UMLS CUI [2])
C0085405 (UMLS CUI [3,1])
C0205435 (UMLS CUI [3,2])
Relapsed | Refractory | Allogeneic Hematopoietic Stem Cell Transplantation
Item
relapsed or refractory within 12 months of allohsct
boolean
C0205336 (UMLS CUI [1])
C0205269 (UMLS CUI [2])
C1705576 (UMLS CUI [3])
Bone marrow Blasts
Item
5% or more blasts in bone marrow
boolean
C1982687 (UMLS CUI [1])
Disease Extramedullary | Sign or Symptom | Disease Medulla Oblongata | Measurable Disease
Item
in case of clinical signs of extramedullary disease in addition to medullary disease, disease must be measurable (at least one lesion ≥ 1.5 cm)
boolean
C0012634 (UMLS CUI [1,1])
C1517060 (UMLS CUI [1,2])
C3540840 (UMLS CUI [2])
C0012634 (UMLS CUI [3,1])
C0025148 (UMLS CUI [3,2])
C1513041 (UMLS CUI [4])
Burkitt Leukemia
Item
subjects with burkitt's leukemia according to world health organization (who) classification
boolean
C0006413 (UMLS CUI [1])
CNS disorder | Epilepsy | Seizures | Paresis | Aphasia | Cerebrovascular accident | Brain Injuries Severe | Dementia | Parkinson Disease | Cerebellar Diseases | Organic brain syndrome | Psychotic Disorders | Central nervous system leukaemia Well controlled
Item
history or presence of clinically relevant cental nervous system (cns) pathology such as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia, parkinson's disease, cerebellar disease, organic brain syndrome, psychosis; with the exception of well controlled cns leukemia
boolean
C0007682 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
C0036572 (UMLS CUI [3])
C0030552 (UMLS CUI [4])
C0003537 (UMLS CUI [5])
C0038454 (UMLS CUI [6])
C0270611 (UMLS CUI [7,1])
C0205082 (UMLS CUI [7,2])
C0497327 (UMLS CUI [8])
C0030567 (UMLS CUI [9])
C0007760 (UMLS CUI [10])
C0029221 (UMLS CUI [11])
C0033975 (UMLS CUI [12])
C1332884 (UMLS CUI [13,1])
C3853142 (UMLS CUI [13,2])
Disorder of central nervous system co-occurrent and due to acute lymphoid leukemia | Acute lymphocytic leukemia Testes
Item
active all in the cns or testes
boolean
C4076109 (UMLS CUI [1])
C0023449 (UMLS CUI [2,1])
C0039597 (UMLS CUI [2,2])
Autoimmune Diseases Involvement with Central Nervous System
Item
current autoimmune disease or history of autoimmune disease with potential cns involvement
boolean
C0004364 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C3714787 (UMLS CUI [1,3])
autologous hematopoietic stem cell transplant | Therapeutic procedure blinatumomab
Item
autologous hsct within 6 weeks prior to start of blinatumomab treatment
boolean
C2193200 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C3853839 (UMLS CUI [2,2])
Allogeneic Hematopoietic Stem Cell Transplantation | Therapeutic procedure blinatumomab
Item
allohsct within 12 weeks prior to start of blinatumomab treatment
boolean
C1705576 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C3853839 (UMLS CUI [2,2])
Acute GVH disease | Glucksberg Scale | Graft-vs-Host Disease chronic | Requirement systemic therapy
Item
any active acute graft-versus-host disease (gvhd) grade 2-4 according to glucksberg criteria or active chronic gchd requiring systemic treatment
boolean
C0856825 (UMLS CUI [1])
C1512203 (UMLS CUI [2])
C0018133 (UMLS CUI [3,1])
C0205191 (UMLS CUI [3,2])
C1514873 (UMLS CUI [4,1])
C1515119 (UMLS CUI [4,2])