Age
Item
1. males or females ≥ 40 and < 70 years of age
boolean
C0001779 (UMLS CUI [1])
Informed consent
Item
2. able to provide written informed consent
boolean
C0021430 (UMLS CUI [1])
Osteoarthritis, Knee | American College of Rheumatology Improvement Criteria
Item
3. diagnosis of osteoarthritis in one or both knees by american college of rheumatology (acr) criteria
boolean
C0409959 (UMLS CUI [1])
C3273747 (UMLS CUI [2])
Kellgren-Lawrence score Knee | x-ray of knee, standing Diagnostic radiography, anteroposterior (AP)
Item
4. kellgren and lawrence grade 2 or 3 (standing ap x-ray) of the target knee within the preceding 6 months
boolean
C3177117 (UMLS CUI [1,1])
C0022742 (UMLS CUI [1,2])
C3861234 (UMLS CUI [2,1])
C0202572 (UMLS CUI [2,2])
Pain Due to Degenerative polyarthritis | Target Knee
Item
5. pain due to osteoarthritis in the target knee ≥ 6 months
boolean
C0030193 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0029408 (UMLS CUI [1,3])
C1521840 (UMLS CUI [2,1])
C0022742 (UMLS CUI [2,2])
KOOS: pain score Moderate Minimum | Pain Difficulty walking on the flat
Item
6. minimum score of "moderate" from koos question about pain on walking on a flat surface.
boolean
C3836985 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C1524031 (UMLS CUI [1,3])
C0030193 (UMLS CUI [2,1])
C0560053 (UMLS CUI [2,2])
KOOS: pain score Moderate Minimum | Difficulty walking on the flat
Item
7. minimum score of "moderate" from koos question about degree of difficulty during walking on a flat surface.
boolean
C3836985 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C1524031 (UMLS CUI [1,3])
C0560053 (UMLS CUI [2])
Knee pain Continuous | Knee Limited function | Conservative therapy
Item
8. continued knee pain and limitations in knee function despite prescription of conservative therapy for at least 6 months.
boolean
C0231749 (UMLS CUI [1,1])
C0549178 (UMLS CUI [1,2])
C0022742 (UMLS CUI [2,1])
C0497533 (UMLS CUI [2,2])
C0459914 (UMLS CUI [3])
Suction Lipectomy Ability | Adipose tissue Quantity Sufficient
Item
9. ability to safely undergo liposuction that will result in the harvest of a sufficient quantity of adipose tissue (approximately 300 ml)
boolean
C0038640 (UMLS CUI [1,1])
C0085732 (UMLS CUI [1,2])
C0001527 (UMLS CUI [2,1])
C1699029 (UMLS CUI [2,2])
Knee pain Due to Degenerative polyarthritis | Analgesics Stable status | Analgesics During Clinical Research
Item
10. on stable regimen of one analgesic medication (rescue medication) for their knee pain due to osteoarthritis and ability and willingness to use the same analgesic medication during the study (screening period through to final study visit).
boolean
C0231749 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0029408 (UMLS CUI [1,3])
C0002771 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
C0002771 (UMLS CUI [3,1])
C0347984 (UMLS CUI [3,2])
C0008972 (UMLS CUI [3,3])
Compliance behavior | Pain Index Evaluation | Able to walk on the flat | Able to walk up stairs | Able to walk down stairs
Item
11. ability to perform procedures required of the pain index evaluations (unassisted walking 50 feet on a flat surface and going up and down stairs)
boolean
C1321605 (UMLS CUI [1])
C0030193 (UMLS CUI [2,1])
C0918012 (UMLS CUI [2,2])
C0220825 (UMLS CUI [2,3])
C0560049 (UMLS CUI [3])
C0560077 (UMLS CUI [4])
C0560081 (UMLS CUI [5])
Major injury Target Knee
Item
1. any major injury to the target knee within the 12 months prior to the screening visit
boolean
C0332677 (UMLS CUI [1,1])
C1521840 (UMLS CUI [1,2])
C0022742 (UMLS CUI [1,3])
Dependence on walking stick | Walking assistive device Needed
Item
2. need for cane or other assistance device for walking
boolean
C0524378 (UMLS CUI [1])
C3874140 (UMLS CUI [2,1])
C0027552 (UMLS CUI [2,2])
Operative Surgical Procedures Target Knee | Operative Surgical Procedures Knee Contralateral | Operative Surgical Procedures Joint Weightbearing
Item
3. any surgery to the target knee within the 6 months prior to the screening visit, or surgery to the contralateral knee or other weight-bearing joint if it will interfere with knee assessments
boolean
C0543467 (UMLS CUI [1,1])
C1521840 (UMLS CUI [1,2])
C0022742 (UMLS CUI [1,3])
C0543467 (UMLS CUI [2,1])
C0022742 (UMLS CUI [2,2])
C0441988 (UMLS CUI [2,3])
C0543467 (UMLS CUI [3,1])
C0022417 (UMLS CUI [3,2])
C1318107 (UMLS CUI [3,3])
Transplantation Articular Previous
Item
4. prior articular transplant procedures
boolean
C0040732 (UMLS CUI [1,1])
C0521339 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,3])
Target Knee | Ligament reconstruction Previous
Item
5. prior ligament reconstruction to the target knee within 12 months prior to the screening visit
boolean
C1521840 (UMLS CUI [1,1])
C0022742 (UMLS CUI [1,2])
C0547071 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
Arthropathy | Rheumatoid Arthritis | Lupus erythematodes Arthropathy | Arthritis, Psoriatic
Item
6. inflammatory arthropathies such as rheumatoid arthritis, lupus arthropathy, or psoriatic arthritis
boolean
C0022408 (UMLS CUI [1])
C0003873 (UMLS CUI [2])
C0866588 (UMLS CUI [3,1])
C0022408 (UMLS CUI [3,2])
C0003872 (UMLS CUI [4])
Gout | Calcium pyrophosphate deposition disease
Item
7. gout or calcium pyrophosphate (pseudogout) diseases that have flared within the previous 6 months prior to the screening visit
boolean
C0018099 (UMLS CUI [1])
C0553730 (UMLS CUI [2])
roentgenographic | Fracture | Bone Density Loss Severe | Avascular necrosis | Target Knee Deformity of bone Severe | Target Knee Joint deformity Severe
Item
8. x-ray findings of acute fractures, known severe loss of bone density (as determined by the investigator), avascular necrosis, and/or severe bone or joint deformity in the target knee (>5 degree valgus or varus deviation from mechanical axis)
boolean
C0034571 (UMLS CUI [1])
C0016658 (UMLS CUI [2])
C0005938 (UMLS CUI [3,1])
C1517945 (UMLS CUI [3,2])
C0205082 (UMLS CUI [3,3])
C3887513 (UMLS CUI [4])
C1521840 (UMLS CUI [5,1])
C0022742 (UMLS CUI [5,2])
C0410719 (UMLS CUI [5,3])
C0205082 (UMLS CUI [5,4])
C1521840 (UMLS CUI [6,1])
C0022742 (UMLS CUI [6,2])
C0427244 (UMLS CUI [6,3])
C0205082 (UMLS CUI [6,4])
Fibromyalgia | Bursitis anserine bursa | Lumbar radiculopathy | Neurogenic claudication | Claudication Vascular
Item
9. fibromyalgia, pes anserine bursitis, lumbar radiculopathy, and/or neurogenic or vascular claudication
boolean
C0016053 (UMLS CUI [1])
C0006444 (UMLS CUI [2,1])
C1305634 (UMLS CUI [2,2])
C1263855 (UMLS CUI [3])
C0580173 (UMLS CUI [4])
C1456822 (UMLS CUI [5,1])
C1801960 (UMLS CUI [5,2])
Knee pain Primary | Patellofemoral osteoarthritis Isolated | chondromalacia knee
Item
10. primary knee pain due to diagnosed isolated patella-femoral arthritis or chondromalacia in the target knee
boolean
C0231749 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
C1542808 (UMLS CUI [2,1])
C0205409 (UMLS CUI [2,2])
C2902706 (UMLS CUI [3])
knee; infection, joint | Dermatologic disorders | Skin Diseases, Infectious
Item
11. significant target knee joint infection or skin disorder/infection within the previous 6 months prior to the screening visit
boolean
C1400581 (UMLS CUI [1])
C0037274 (UMLS CUI [2])
C0037278 (UMLS CUI [3])
Osteoarthritis of hip Symptomatic | Osteoarthritis, Spine Symptomatic | Osteoarthritis of ankle Symptomatic | Target Knee Evaluation
Item
12. symptomatic oa of the hips, spine, or ankle, if it would interfere with the evaluation of the target knee
boolean
C0029410 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C2350242 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0409931 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
C1521840 (UMLS CUI [4,1])
C0022742 (UMLS CUI [4,2])
C0220825 (UMLS CUI [4,3])
medical condition Requirement Immunosuppressive Agents | medical condition Requirement systemic steroids
Item
13. any condition requiring immunosuppressive medication or use of systemic steroids
boolean
C1699700 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0021081 (UMLS CUI [1,3])
C1699700 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C2825233 (UMLS CUI [2,3])
intraarticular injection of corticosteroids | Intra-Articular Injection Hyaluronic Acid Knee
Item
14. intra-articular injection of steroids in previous 3 months or hyaluronic acid in previous 6 months in one or both knees prior to the screening visit
boolean
C2064783 (UMLS CUI [1])
C0021488 (UMLS CUI [2,1])
C0020196 (UMLS CUI [2,2])
C0022742 (UMLS CUI [2,3])
Platelet rich plasma | Blood Platelets Product base | Study Subject Participation Status
Item
15. patients that have received prp, other platelet-based product, or investigational treatment in another cell/biologic study for the targeted treatment injury in the 12 months prior to the injection procedure
boolean
C0370220 (UMLS CUI [1])
C0005821 (UMLS CUI [2,1])
C0360301 (UMLS CUI [2,2])
C2348568 (UMLS CUI [3])
Study Subject Participation Status | Investigational New Drugs | Investigational Medical Device
Item
16. participation in any experimental drug or device study within the 6 months prior to the screening visit
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
C2346570 (UMLS CUI [3])
Obesity | Body mass index
Item
17. obesity defined as bmi > 35 kg/m2
boolean
C0028754 (UMLS CUI [1])
C1305855 (UMLS CUI [2])