Stable status | Multiple Sclerosis | Age | Kurtzke multiple sclerosis rating scale
Item
stable patients with clinically definite ms, aged ≥18, edss of 0-7.5
boolean
C0205360 (UMLS CUI [1])
C0026769 (UMLS CUI [2])
C0001779 (UMLS CUI [3])
C0451246 (UMLS CUI [4])
Stable status Clinical | Exacerbation of multiple sclerosis | Biological Response Modifier Therapy Changing
Item
clinical stability defined as no ms exacerbation or change in disease modifying therapy for 30 days prior to screening.
boolean
C0205360 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C0581392 (UMLS CUI [2])
C0005527 (UMLS CUI [3,1])
C0392747 (UMLS CUI [3,2])
Kurtzke multiple sclerosis rating scale
Item
edss as described above
boolean
C0451246 (UMLS CUI [1])
Medical contraindication Oxford grading scale for muscle strength
Item
contraindications to strength testing:
boolean
C1301624 (UMLS CUI [1,1])
C0451362 (UMLS CUI [1,2])
Myositis
Item
inflammatory myopathy
boolean
C0027121 (UMLS CUI [1])
Endocarditis | Pericarditis | Heart Diseases Unstable status
Item
endocarditis, pericarditis or other unstable heart disease
boolean
C0014118 (UMLS CUI [1])
C0031046 (UMLS CUI [2])
C0018799 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
Cardiac Surgery procedures | Myocardial Infarction
Item
cardiac surgery or myocardial infarction in the last 3 months
boolean
C0018821 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
CONGESTIVE HEART FAILURE DECOMPENSATED
Item
decompensated congestive heart failure
boolean
C0742746 (UMLS CUI [1])
Aortic stenosis, severe
Item
severe aortic stenosis
boolean
C3806272 (UMLS CUI [1])
Pulmonary hypertension, severe
Item
severe pulmonary hypertension
boolean
C2750273 (UMLS CUI [1])
Pulmonary Embolism | Pulmonary Infarction
Item
pulmonary embolus or infarction in the last 6 months
boolean
C0034065 (UMLS CUI [1])
C0034074 (UMLS CUI [2])
Uncontrolled hypertension | Diastolic blood pressure | Systolic Pressure
Item
uncontrolled hypertension by history or by screening or baseline diastolic blood pressure >170, or systolic blood pressure > 105)
boolean
C1868885 (UMLS CUI [1])
C0428883 (UMLS CUI [2])
C0871470 (UMLS CUI [3])
Marfan Syndrome
Item
marfan's syndrome
boolean
C0024796 (UMLS CUI [1])
Artificial cardiac pacemaker | presence of cardiac defibrillator
Item
pacemaker or cardiac defibrillator
boolean
C0030163 (UMLS CUI [1])
C1391956 (UMLS CUI [2])
Neurodegenerative Disorders Nervous system disorder | Amyotrophic Lateral Sclerosis | Parkinson Disease | Hemiplegia Cerebrovascular accident
Item
concomitant neurodegenerative neurological disease, such as als or parkinson disease or hemiplegic stroke
boolean
C0524851 (UMLS CUI [1,1])
C0027765 (UMLS CUI [1,2])
C0002736 (UMLS CUI [2])
C0030567 (UMLS CUI [3])
C0018991 (UMLS CUI [4,1])
C0038454 (UMLS CUI [4,2])
Pregnancy
Item
females who are pregnant
boolean
C0032961 (UMLS CUI [1])
Cognition Disorders Interferes with Ability Informed Consent | Cognition Disorders Compliance behavior Limited
Item
cognitive deficits that would interfere with the subject's ability to give informed consent or perform study testing.
boolean
C0009241 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0085732 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])
C0009241 (UMLS CUI [2,1])
C1321605 (UMLS CUI [2,2])
C0439801 (UMLS CUI [2,3])
Therapeutic procedure Novantrone | Therapeutic procedure Mitoxantrone | Chemotherapy Malignant Neoplasms | Operative Surgical Procedures
Item
anticipated treatment with novantrone (mitoxantrone) or cancer chemotherapy or surgical procedure during the study period
boolean
C0087111 (UMLS CUI [1,1])
C0282248 (UMLS CUI [1,2])
C0087111 (UMLS CUI [2,1])
C0026259 (UMLS CUI [2,2])
C0392920 (UMLS CUI [3,1])
C0006826 (UMLS CUI [3,2])
C0543467 (UMLS CUI [4])
orthopedic problem Pain Affecting Lower Extremity
Item
painful orthopedic condition affecting the lower extremities
boolean
C0029354 (UMLS CUI [1,1])
C0030193 (UMLS CUI [1,2])
C0392760 (UMLS CUI [1,3])
C0023216 (UMLS CUI [1,4])
medical condition Serious | medical condition Unstable status
Item
any other serious and/or unstable medical condition
boolean
C1699700 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C1699700 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])